Reactome | RPL7 [cytosol]

RPL7 [cytosol]

Stable Identifier

R-SSC-72486

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPL7, A0A287A8T0

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
- rRNA processing (Sus scrofa)
  - rRNA processing in the nucleus and cytosol (Sus scrofa)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Sus scrofa)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Translation (Sus scrofa)
  - Eukaryotic Translation Initiation (Sus scrofa)
    - Cap-dependent Translation Initiation (Sus scrofa)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Sus scrofa)
        
        eIF5B:GTP is hydrolyzed and released (Sus scrofa)
        
        80S:Met-tRNAi:mRNA [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Sus scrofa)
      - Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
        
        60s ribosomal complex lacking L13a subunit [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
  - SRP-dependent cotranslational protein targeting to membrane (Sus scrofa)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)
      - SRP:polypeptide+signal:ribosome [cytosol] (Sus scrofa)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPL7 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287A8T0

Gene Names

RPL7

Reference Genes

ENSEMBL:ENSSSCG00000032111

Other Identifiers

414418

走:0000463

走:0003674

走:0003677

走:0003723

走:0003729

走:0003735

走:0005198

走:0005575

走:0005622

走:0005737

走:0005829

走:0005840

走:0006364

走:0008150

去:0014069

走:0022625

走:0022626

走:0032991

走:0034641

走:0042254

走:0042273

走:0042802

走:0043226

走:1990904

Ssc.30184.1.A1_at

Ssc.3842.1.A1_at

Participates

as a component of

Inferred From

RPL7 [cytosol](Homo sapiens)

交叉引用

OpenTargets

ENSG00000147604

Ensembl

ENSSSCG00000032111,ENSSSCP00000040219,ENSSSCT00000052920

VGNC

98850

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