Reactome | AP2A1 [cytosol]

AP2A1 [cytosol]

Stable Identifier

R-SSC-182143

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

AP2A1, F1RH60

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Signaling by WNT (Sus scrofa)
  - Beta-catenin independent WNT signaling (Sus scrofa)
    - PCP/CE pathway (Sus scrofa)
      - WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Sus scrofa)
        
        FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)
        
        clathrin:AP-2 [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - WNT5A-dependent internalization of FZD4 (Sus scrofa)
        
        WNT5A:FZD4 is endocytosed (Sus scrofa)
        
        WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        clathrin:AP-2 [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Sus scrofa)
        
        WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        clathrin:AP-2 [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        clathrin:AP-2 [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - AP-2 directly binds some endocytic cargo (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        AP2:chlorpromazine [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - AP2 binds chlorpromazine (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        AP2:chlorpromazine [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - HSPA8-mediated ATP水解促进囊泡uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        Clathrin-coated vesicle [cytosol] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)
      - AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
      - π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        π(4、5)P2: p-T156 AP-2:网格蛋白:ITSNs: EPS15: REPS1: SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)
        
        p-T156 AP-2 Complex [cytosol] (Sus scrofa)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)
        
        AP2A1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RH60

Gene Names

AP2A1

Reference Genes

ENSEMBL:ENSSSCG00000003199

Other Identifiers

100520250

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005975

GO:0006810

GO:0006886

GO:0008150

GO:0009058

GO:0015031

GO:0016192

GO:0019899

GO:0019901

GO:0030117

GO:0030122

GO:0030131

GO:0030674

GO:0031410

GO:0032433

GO:0032991

GO:0035615

GO:0043226

GO:0044281

GO:0050750

GO:0072583

GO:1900126

Participates

as a member of

Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Sus scrofa)

Other forms of this molecule

AP2A1 [endolysosome membrane]

AP2A1 [endocytic vesicle membrane]

AP2A1 [clathrin-coated endocytic vesicle membrane]

AP2A1 [plasma membrane]

Inferred From

AP2A1 [cytosol](Homo sapiens)

Cross References

OpenTargets

ENSG00000196961

Ensembl

ENSSSCG00000003199,ENSSSCP00000003471,ENSSSCT00000003554

VGNC

85383

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