Reactome | p-AMPK alpha[胞质]

自噬(粟酒裂殖酵母)

- Macroautophagy(粟酒裂殖酵母)
  - AMPK(复合物)磷酸化ULK1(复合物)(裂殖酵母)
    - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
      - p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:p- s317、467、556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - ULK1的Thr-180被磷酸化(schizossaccharomyces pombe)
    - p-AMPK heterotrimer:AMP:p- s317、467、556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - ULK复合体向ER(裂殖酵母)的易位
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101[内质网膜](schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - ULK1磷酸化AMBRA1:BECN1复合物(schizossaccharomyces pombe)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101[内质网膜](schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - ULK1磷酸化ATG13和RB1CC1(裂殖酵母)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - ULK1磷酸化Beclin-1(裂殖酵母)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101[内质网膜](schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
  - p-AMPK:AMP结合ULK复合物(schizossaccharomyces pombe)
    - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
      - p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (schizossaccharomyces pombe)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)

裂殖酵母基因表达(转录)

- RNA聚合酶II转录(裂殖酵母)
  - 基因转录途径(裂殖酵母)
    - TP53对裂殖酵母的转录调控
      - TP53调控代谢基因(裂殖酵母)
        
        p-AMPK磷酸化TSC1:TSC2(裂殖酵母)
        
        p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)

信号转导(裂殖酵母)

- MTOR信号(裂殖酵母)
  - LKB1-AMPK对mTOR的能量依赖调控
    - 磷酸化AMPK结合AMP(裂殖酵母)
      - p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)
    - p-AMPK磷酸化TSC1:TSC2(裂殖酵母)
      - p-AMPK异源三聚体:AMP[胞质](schizossaccharomyces pombe)
        
        p-AMPK异源三聚体
        
        p-AMPK α[胞质](裂殖酵母)

p-AMPKα(胞质)