Reactome | phospho-H2afx[核质]

phospho-H2afx(核浆)

稳定的标识符

r -优化- 5682847

类型

蛋白质(EntityWithAccessionedSequence)

物种

鼠形

室

核浆

同义词

K63PolyUb-K14、K16 p-S140-H2AFX D3ZXP3

路径浏览器中的位置

全部展开

细胞周期(褐家鼠)

- 细胞周期检查点(褐家鼠)
  - G2/M检查点(褐家鼠)
    - G2/M DNA损伤检查点(褐家鼠)
      - CHEK2被招募到DNA dsb(褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8: rnf1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合物:CHEK2[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - 褐家鼠ATM对CHEK2的磷酸化和激活
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8: rnf1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合物:CHEK2[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)

DNA修复(褐家鼠)

- DNA双链断裂修复(褐家鼠)
  - DNA双链断裂反应(褐家鼠)
    - DNA双链断裂修复和信号蛋白的募集和atm介导的磷酸化(褐家鼠)
      - ATM磷酸化DNA dsb上的TP53BP1(褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - CHEK2被招募到DNA dsb(褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8: rnf1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合物:CHEK2[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - CHEK2磷酸化BRCA1(褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - PPP5C去磷酸化TP53BP1(褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - 褐家鼠ATM对CHEK2的磷酸化和激活
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8: rnf1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合物:CHEK2[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - ATM对褐家鼠BRCA1-A复合体多位点磷酸化的研究
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - RNF8和RNF168泛素化H2AFX(褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63聚脲- k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:KDM4A,B:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - RNF8和RNF168泛素化KDM4A,B(褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63聚脲- k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:KDM4A,B:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - TP53BP1与H4K20Me2在褐家鼠DNA dsb上的关联
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - UIMC1和FAM175A结合褐家鼠DNA dsb
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:UIMC1:p-S406-FAM175A[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
  - 同源定向修复(褐家鼠)
    - 同源重组(HRR)或单链退火(SSA) HDR(褐家鼠)
      - DNA双链断裂端加工(褐家鼠)
        
        PIAS4 SUMOylates MDC1(褐家鼠)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:SUMO2:K1840,p-5T-MDC1[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A复合体[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
  - 非同源末端连接(NHEJ)(褐家鼠)
    - 激活的ATM磷酸化DCLRE1C(褐家鼠)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63聚脲- k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - 褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
    - TP53BP1向褐家鼠ATM (Rattus norvegicus)招募DCLRE1C
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63聚脲- k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)
      - 褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63mu - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1[核质]
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4[核质](褐家鼠)
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1:p-S102-WHSC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体:p-5T-MDC1[核质]
        
        褐家鼠DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5: k63polyb - k14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质]
        
        k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)
        
        磷酸- h2afx[核质](褐家鼠)

外部参考信息

外部引用

UniProt: D3ZXP3

基因名字

H2afx

参考基因

BioGPS基因号:500987

运用:ENSRNOG00000010386

KEGG基因(褐家鼠):500987 H2afx

君主:500987 H2afx

NCBI基因:500987 H2afx

UCSC: D3ZXP3 H2afx

参考文本

RefSeq: NM_001109291.1 H2afx

其他标识符

10909480

1390384 _at

17843590

500987

6012479

6391405

A_44_P988451

GE19257

去:0000003

去:0000077

去:0000228

去:0000724

去:0000781

去:0000785

去:0000786

去:0000794

去:0001673

去:0001741

去:0003674

去:0003677

去:0003684

去:0005575

去:0005622

去:0005634

去:0005654

去:0005657

去:0005694

去:0005813

去:0005815

去:0005856

去:0006259

去:0006281

去:0006342

去:0006950

去:0006974

去:0007049

去:0007283

去:0007568

去:0008150

去:0009058

去:0016607

去:0019899

去:0021987

去:0032991

去:0034641

去:0035861

去:0042393

去:0043226

去:0046982

去:0048856

去:0051276

去:0071480

去:0090398

去:0090734

ILMN_1349617

PH_rn_0000495

rc_AA875257_at

参与

作为

k63polyb:K14,K16,p-S139-H2AFX, me2k21 - hist1h4a -核小体[核质](褐家鼠)

这种分子的其他形式

H2afx(核浆)

phospho-H2afx(核浆)

推断出从

K63PolyUb-K14、K16 p-S140-H2AFX(核浆)(智人)

修改后的残留物

名字

o-磷酸- l -丝氨酸在140(智人)

协调

140

PsiMod名字

O-phospho-L-serine (MOD: 00046)

PsiMod定义

将l -丝氨酸残基有效地转化为o-磷酸l -丝氨酸的一种蛋白质修饰。

名字

泛素化赖氨酸(k63polyb[核质])在14位点(智人)

协调

修改

K63polyUb(核浆)

PsiMod名字

泛素化赖氨酸[MOD:01148]

PsiMod定义

使肽基赖氨酸的n6 -氨基与泛素的羧基末端甘氨酸有效交联的一种蛋白质修饰。

名字

泛素化赖氨酸(k63polyb[核质])在16位点(智人)

协调

修改

K63polyUb(核浆)

PsiMod名字

泛素化赖氨酸[MOD:01148]

PsiMod定义

使肽基赖氨酸的n6 -氨基与泛素的羧基末端甘氨酸有效交联的一种蛋白质修饰。

交叉引用

RefSeq

NP_001102761.1

运用

ENSRNOT00000059715，ENSRNOP00000056469，ENSRNOG00000010386

箴

D3ZXP3

RGD

1566119

引用我们!