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NPRL2 [lysosomal membrane]
Stable Identifier
R-HSA-9638226
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
fullName evidence="11"GATOR complex protein NPRL2, NPRL2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL2 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WTW4 NPRL2
Gene Names
NPRL2, TUSC4
Chain
chain:1-380
Reference Genes
BioGPS Gene:10641 NPRL2
COSMIC (genes):NPRL2 NPRL2
CTD Gene:10641 NPRL2
dbSNP Gene:10641 NPRL2
ENSEMBL:ENSG00000114388 NPRL2
HGNC:24969 NPRL2
KEGG Gene (Homo sapiens):10641 NPRL2
Monarch:10641 NPRL2
NCBI Gene:10641 NPRL2
OMIM:607072 NPRL2
UCSC:Q8WTW4 NPRL2
Reference Transcript
RefSeq:NM_006545.4 NPRL2
Other Identifiers
0000770451
10641
11718094_a_at
11744766_a_at
11754935_x_at
16954478
203246_s_at
2675269
2675270
2675271
2675273
2675276
2675278
2675280
2675282
2675283
2675285
2675289
2675291
2675293
2675297
2675298
2675299
2675300
40497_at
40498_g_at
8087669
A_23_P18266
GE54349
GO:0003674
GO:0004672
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0006464
GO:0006468
GO:0006914
GO:0006950
GO:0006995
GO:0007165
GO:0008150
GO:0009056
GO:0010508
GO:0016020
GO:0016301
GO:0022607
GO:0030234
GO:0032007
GO:0032991
GO:0033673
去:0034198
GO:0043226
GO:0043547
GO:1990130
GO:2000785
HMNXSV003040031
ILMN_1691272
PH_hs_0020639
g2935584_3p_a_at
Participates
as a component of
GATOR1 [lysosomal membrane] (Homo sapiens)
Inferred To
Nprl2 [lysosomal membrane]
(Mus musculus)
Nprl2 [lysosomal membrane]
(鼠形)
NPRL2 [lysosomal membrane]
(Canis familiaris)
NPRL2 [lysosomal membrane]
(Dictyostelium discoideum)
NPRL2 [lysosomal membrane]
(Gallus gallus)
“大酒店”ost homologue of NPRL2 [lysosomal membrane]
(Sus scrofa)
nprl2 [lysosomal membrane]
(Danio rerio)
nprl2 [lysosomal membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006536.3
OpenTargets
ENSG00000114388
HPA
ENSG00000114388-NPRL2
GeneCards
Q8WTW4
Ensembl
ENSG00000114388
,
ENSP00000232501
,
ENST00000232501
PRO
Q8WTW4
Pharos - Targets
Q8WTW4
PDB
6CET
,
6CES
HMDB Protein
HMDBP11865
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