Reactome | RPS11 [cytosol]

RPS11 [cytosol]

Stable Identifier

R-HSA-72327

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 11, P04643, 40S ribosomal protein S11

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62280 RPS11

Gene Names

RPS11

Chain

initiator methionine:1, chain:2-158

Reference Genes

BioGPS Gene:6205 RPS11

COSMIC (genes):RPS11 RPS11

CTD Gene:6205 RPS11

dbSNP Gene:6205 RPS11

ENSEMBL:ENSG00000142534 RPS11

HGNC: 10384 RPS11

KEGG Gene (Homo sapiens):6205 RPS11

Monarch:6205 RPS11

NCBI Gene:6205 RPS11

OMIM:180471 RPS11

UCSC:P62280 RPS11

Reference Transcript

RefSeq:NM_001015.4 RPS11

Other Identifiers

11715376_a_at

11745362_x_at

16864159

18671238

18671239

18671241

18671242

200031_PM_s_at

200031_s_at

32330_at

3439262

3439263

3838608

3838609

3838612

3838615

3838619

3838620

6205

7893727

7893956

7894634

7894999

7895762

8030368

GE78949

GO:0000184

GO:0002181

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0008150

GO:0009056

GO:0009058

GO:0015031

GO:0016020

GO:0019083

GO:0019843

GO:0022626

GO:0022627

GO:0032991

GO:0034641

GO:0034655

GO:0043226

GO:0044403

GO:0070062

PH_hs_0030181

TC19000735.hg

X06617_at

g4506680_3p_a_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS11 [nucleoplasm]

Inferred To

RPS11A [cytosol](Saccharomyces cerevisiae)

RpS11 [cytosol](Drosophila melanogaster)

rps1101 [cytosol](Schizosaccharomyces pombe)

Rps11 [cytosol](Mus musculus)

Rps11 [cytosol](Rattus norvegicus)

rps-11 [cytosol](Caenorhabditis elegans)

rps11 [cytosol](Danio rerio)

rps11 [cytosol](Dictyostelium discoideum)

rps11 [cytosol](Xenopus tropicalis)

rps1102 [cytosol](Schizosaccharomyces pombe)

cRPS11 [cytosol](Gallus gallus)

LOC100684832 [cytosol](Canis familiaris)

RPS11 [cytosol](Bos taurus)

RPS11 [cytosol](Canis familiaris)

RPS11 [cytosol](Plasmodium falciparum)

RPS11 [cytosol](Sus scrofa)

Homologues of RPS11 [cytosol](Canis familiaris)

Homologues of RPS11 [cytosol](Saccharomyces cerevisiae)

Homologues of RPS11 [cytosol](Schizosaccharomyces pombe)

RPS11B [cytosol](Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001006.1

OpenTargets

ENSG00000142534

GeneCards

P62280

HPA

ENSG00000142534-RPS11

Ensembl

ENST00000270625,ENSG00000142534,ENSP00000270625

PRO

P62280

Pharos - Targets

P62280

GlyGen

P62280

PDB

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol](R-HSA-5661173)	0.642	5
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol](R-HSA-168189) Active NIK [cytosol](R-HSA-5607646) p-MAP3K14 [cytosol](R-HSA-168187) K48polyUb-NIK [cytosol](R-HSA-5668525) p-T559-MAP3K14 [cytosol](R-HSA-5668531)	0.564	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol](R-HSA-5626956)	0.495	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane](R-HSA-9021059) PalmS-ESR2 [cytosol](R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane](R-HSA-9637787) ESR2 [nucleoplasm](R-HSA-446165) ESR2 [cytosol](R-HSA-9020970)	0.462	2
UniProt:Q00005 2ABB			0.462	2

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