WRN [nucleoplasm]

Stable Identifier
R-HSA-67387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Werner syndrome helicase
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q14191 WRN
Gene Names
WRN, RECQ3, RECQL2
Chain
initiator methionine:1, chain:2-1432
Reference Genes
BioGPS Gene:7486 WRN
COSMIC (genes):WRN WRN
CTD Gene:7486 WRN
dbSNP Gene:7486 WRN
ENSEMBL:ENSG00000165392 WRN
HGNC:12791 WRN
KEGG Gene (Homo sapiens):7486 WRN
Monarch:7486 WRN
NCBI Gene:7486 WRN
OMIM:604611 WRN
UCSC:Q14191 WRN
Reference Transcript
Other Identifiers
0005700575
11732584_a_at
17067632
17067672
205667_at
3092664
3092666
3092667
3092668
3092670
3092671
3092672
3092674
3092681
3092683
3092684
3092685
3092688
3092690
3092691
3092692
3092693
3092694
3092695
3092696
3092697
3092699
3092700
3092702
3092705
3092706
3092713
3092716
3092717
3092718
3092719
3092720
3092721
3092722
3092725
3092726
3092727
3092731
3092732
3092733
3092734
3092735
3092736
3092738
38136_at
47690_at
7486
8145702
A_14_P117520
A_14_P123326
A_14_P137673
A_19_P00809110
A_21_P0005679
A_23_P250813
GE57795
GO:0000166
GO:0000287
GO:0000400
GO:0000403
GO:0000405
GO:0000723
GO:0000724
GO:0000731
GO:0000781
GO:0003674
GO:0003676
GO:0003677
GO:0003678
GO:0003682
GO:0003824
GO:0004386
GO:0004518
GO:0004527
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006139
GO:0006259
GO:0006260
GO:0006268
GO:0006281
GO:0006284
GO:0006302
GO:0006310
GO:0006950
GO:0006974
GO:0006979
GO:0007049
GO:0007165
GO:0007420
GO:0007568
GO:0007569
GO:0008150
GO:0008152
GO:0008219
GO:0008408
GO:0009058
GO:0009267
GO:0009378
GO:0010225
GO:0010259
GO:0016607
GO:0016787
去:0016887
GO:0022607
GO:0030145
GO:0031297
GO:0032201
GO:0032405
GO:0032508
GO:0034641
GO:0040007
GO:0040009
GO:0042592
GO:0042803
GO:0042981
GO:0043005
GO:0043138
GO:0043167
GO:0043226
GO:0044237
GO:0044806
GO:0044877
GO:0046872
GO:0048856
GO:0051276
GO:0051345
GO:0051880
GO:0061749
GO:0061820
GO:0061821
GO:0061849
GO:0070337
GO:0071480
GO:0090305
GO:0090399
GO:0090656
GO:0098530
GO:1901796
GO:1902570
GO:1905773
HMNXSV003031434
HMNXSV003031934
ILMN_1679881
ILMN_1887539
ILMN_3251756
L76937_rna1_at
PH_hs_0026827
TC08000246.hg
TC08001869.hg
g5739523_3p_at
Participates
as an input of
as a member of
as a candidate of
as a component of
This entity regulates
Positively
Other forms of this molecule
SUMO1-K356,K496,K898-WRN [nucleoplasm]
Inferred To
WRN [nucleoplasm]（Bos taurus)
WRN [nucleoplasm]（Canis familiaris)
WRN [nucleoplasm]（Gallus gallus)
WRN [nucleoplasm]（Plasmodium falciparum)
WRN [nucleoplasm]（Sus scrofa)
Wrn [nucleoplasm]（Mus musculus)
Wrn [nucleoplasm]（Rattus norvegicus)
wrn-1 [nucleoplasm]（Caenorhabditis elegans)
wrn [nucleoplasm]（Danio rerio)
wrn [nucleoplasm]（Xenopus tropicalis)
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
UniProt:P12956 XRCC6 5 0.864 9
UniProt:P13010 XRCC5 4 0.853 9
UniProt:P39748 FEN1 1 0.822 9
UniProt:P27694 RPA1 2 0.818 9
UniProt:Q96EB6 SIRT1 1 0.761 9
UniProt:P09874 PARP1 4 0.739 8
UniProt:P43351 RAD52 3 0.675 9
UniProt:P16104 H2AX 7 0.667 6
UniProt:Q15554 TERF2 2 0.655 8
UniProt:P54132 BLM 2 0.655 9
UniProt:P04637 TP53 1328 0.647 5
UniProt:P35244 RPA3 1 0.508 2
UniProt:P36405 ARL3 1 0.508 2
UniProt:Q9UGP5 POLL 1 0.508 2
UniProt:P45973 CBX5 2 0.499 3
UniProt:P15927 RPA2 2 0.491 3

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