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SPHK1 [cytosol]
Stable Identifier
R-HSA-391267
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sphingosine kinase 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SPHK1 phosphorylates SPG to S1P (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Homo sapiens)
SPHK [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC磷酸化鞘氨醇激酶1 (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
HGNC:11240 SPHK1
KEGG Gene (Homo sapiens):8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_021972.3 SPHK1
RefSeq:NM_001142601.1 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_182965.2 SPHK1
RefSeq:NM_001142602.1 SPHK1
Other Identifiers
0000380541
0000610138
11755046_a_at
16838059
219257_s_at
3735479
3735480
3735481
3735488
3735489
3735490
3735491
3735492
3735494
3735495
3735496
3735497
3735498
3735499
3735500
51923_at
8010061
8877
A_14_P120136
A_14_P125492
A_23_P38106
A_33_P3222069
GE61925
GO:0000166
GO:0000278
GO:0000287
GO:0001568
GO:0001727
GO:0002376
GO:0003376
GO:0003674
GO:0003677
GO:0003951
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005905
GO:0006259
GO:0006457
GO:0006464
GO:0006473
GO:0006629
GO:0006665
GO:0006670
GO:0006810
GO:0006950
GO:0006954
GO:0007049
GO:0007165
GO:0007420
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008289
GO:0008481
GO:0009056
GO:0009058
GO:0010008
GO:0010800
GO:0010803
GO:0016020
GO:0016192
GO:0016301
GO:0016310
去:0016407
GO:0016740
GO:0016746
GO:0017050
GO:0019722
GO:0019899
GO:0030054
GO:0030100
GO:0030139
GO:0030148
GO:0030307
GO:0030335
GO:0031398
GO:0031410
GO:0031901
GO:0032651
GO:0032740
GO:0034612
GO:0034641
GO:0035556
GO:0035924
GO:0038036
GO:0040007
GO:0040011
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0044281
GO:0045202
GO:0045766
GO:0045840
GO:0045931
GO:0045987
GO:0046512
GO:0046521
GO:0046834
GO:0048146
GO:0048646
GO:0048856
GO:0048870
GO:0050764
GO:0051092
GO:0051721
GO:0061024
GO:0070301
GO:0071363
GO:0071897
GO:0090520
GO:0098793
GO:0140014
GO:0150077
GO:1900060
GO:1900745
去:1901224
GO:1903978
GO:1905364
HMNXSV003001592
ILMN_1702032
ILMN_1774153
ILMN_2357134
PH_hs_0004080
TC17000872.hg
g11464966_3p_a_at
Participates
as a component of
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
as an input of
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
PKC磷酸化鞘氨醇激酶1 (Homo sapiens)
as a member of
SPHK [cytosol] (Homo sapiens)
Other forms of this molecule
p-S225-SPHK1 [cytosol]
Inferred To
SPHK1 [cytosol]
(Canis familiaris)
SPHK1 [cytosol]
(Danio rerio)
SPHK1 [cytosol]
(Gallus gallus)
SPHK1 [cytosol]
(Sus scrofa)
Sphk1 [cytosol]
(Mus musculus)
Sphk1 [cytosol]
(Rattus norvegicus)
sphk-1 [cytosol]
(Caenorhabditis elegans)
LCB5 [cytosol]
(Saccharomyces cerevisiae)
lcb4 [cytosol]
(Schizosaccharomyces pombe)
sphk1 [cytosol]
(Xenopus tropicalis)
Sk1 [cytosol]
(Drosophila melanogaster)
sgkB [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
XP_005257823.1
,
NP_892010.2
,
NP_001136073.1
,
NP_068807.2
,
NP_001136074.1
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ZINC - Substances
SPHK1_HUMAN
ZINC - Biogenic
SPHK1_HUMAN
ZINC target
Q9NYA1
PRO
Q9NYA1
PDB
3VZD
,
4L02
,
3VZB
,
3VZC
,
4V24
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
GeneCards
Q9NYA1
HPA
ENSG00000176170-SPHK1
Ensembl
ENST00000592299
,
ENSP00000468547
,
ENSP00000440970
,
ENST00000545180
,
ENST00000392496
,
ENST00000590959
,
ENSP00000376285
,
ENSP00000313681
,
ENSG00000176170
,
ENST00000323374
,
ENSP00000465726
Pharos - Targets
Q9NYA1
Orphanet
29686
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
扶少团团员(3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
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