Reactome | CD86 [plasma membrane]

CD86 [plasma membrane]

Stable Identifier

R-HSA-179784

Type

蛋白质(EntityWithAccessionedSequence)

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD86 monomer

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
        
        CD86 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
        
        CD86 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
        
        CD86 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
        
        CD86 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42081 CD86

Gene Names

CD86, CD28LG2

Chain

signal peptide:1-23, chain:24-329

Reference Genes

BioGPS Gene:942 CD86

COSMIC (genes):CD86 CD86

CTD Gene:942 CD86

dbSNP Gene:942 CD86

ENSEMBL:ENSG00000114013 CD86

HGNC:1705 CD86

KEGG Gene (Homo sapiens):942 CD86

Monarch:942 CD86

NCBI Gene:942 CD86

OMIM:601020 CD86

UCSC:P42081 CD86

Reference Transcript

Other Identifiers

0000360435

0006450068

0006900133

11724997_a_at

11724998_a_at

11736375_a_at

11746658_a_at

11751135_a_at

16944618

205685_at

205686_s_at

210895_s_at

2638790

2638797

2638798

2638801

2638809

2638810

2638815

2638820

2638821

2638822

2638823

36270_at

54585_at

7896700

7896718

8082035

942

A_14_P116067

A_14_P120633

A_23_P109988

A_24_P131589

GE58874

GO:0001618

GO:0002250

GO:0002376

GO:0002639

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005815

GO:0005856

GO:0005886

GO:0006464

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0007202

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0009897

GO:0009986

GO:0015026

GO:0016020

GO:0016021

GO:0016032

GO:0019221

GO:0023035

GO:0030154

GO:0031295

GO:0032743

GO:0032753

GO:0032761

GO:0034451

GO:0034641

GO:0038023

GO:0042102

GO:0042113

GO:0042130

去:0043226

GO:0044403

GO:0045630

GO:0045893

GO:0046718

GO:0048856

GO:0051897

GO:0070062

GO:0071222

去:1901224

GO:1990051

HMNXSV003050629

Hs.27954.0.S2_3p_at

ILMN_1651349

ILMN_1672097

ILMN_1714602

ILMN_1760526

ILMN_1782560

PH_hs_0002458

TC03000626.hg

U04343_at

g416368_3p_a_at

g5901919_3p_a_at

Participates

as a member of

as a component of

CD28:B7-2 [plasma membrane] (Homo sapiens)

as an input of

CD28 homodimer binds B7-2 monomer (Homo sapiens)

Inferred To

Cd86 [plasma membrane](Mus musculus)

Cd86 [plasma membrane](鼠形)

CD86 [plasma membrane](Bos taurus)

CD86 [plasma membrane](Canis familiaris)

CD86 [plasma membrane](Danio rerio)

CD86 [plasma membrane](Sus scrofa)

Homologues of CD86 [plasma membrane](Danio rerio)

si:dkey-15j16.3 [plasma membrane](Danio rerio)

CD80 [plasma membrane](Gallus gallus)

si:dkey-15j16.6 [plasma membrane](Danio rerio)

Cross References

RefSeq

NP_001193854.1,NP_795711.1,NP_787058.4,NP_008820.3,NP_001193853.1

Guide to Pharmacology - Targets

2745

OpenTargets

ENSG00000114013

GeneCards

P42081

HPA

ENSG00000114013-CD86

Ensembl

ENST00000469710,ENST00000264468,ENSP00000418988,ENSP00000420230,ENSP00000377248,ENSP00000332049,ENSG00000114013,ENSP00000264468,ENST00000393627,ENST00000330540,ENST00000493101

PRO

P42081

Pharos - Targets

P42081

Orphanet

25957

GlyGen

P42081

PDB

1I85,5YXK,1 ncn

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16410 CTLA4	2	CTLA4 [plasma membrane](R-HSA-179764) p-Y165,Y182-CTLA4 [plasma membrane](R-HSA-388754)	0.692	3

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