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p-S19,S23-NFKBIB [cytosol]
Stable Identifier
R-HSA-177670
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
室
cytosol
Synonyms
p-S19,S23-IkBB, NF-kappaB inhibitor beta(phosphorylated)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
NF-kappaB p65:p65:p-IKB [cytosol] (Homo sapiens)
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
p-S19,S23-NFKBIB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15653 NFKBIB
Gene Names
NFKBIB, IKBB, TRIP9
Chain
chain:1-356
Reference Genes
BioGPS Gene:4793 NFKBIB
COSMIC (genes):NFKBIB NFKBIB
CTD Gene:4793 NFKBIB
dbSNP Gene:4793 NFKBIB
ENSEMBL:ENSG00000104825 NFKBIB
ENSEMBL:ENSG00000282905 NFKBIB
HGNC:7798 NFKBIB
KEGG Gene (Homo sapiens):4793 NFKBIB
Monarch:4793 NFKBIB
NCBI Gene:4793 NFKBIB
OMIM:604495 NFKBIB
UCSC:Q15653 NFKBIB
Reference Transcript
RefSeq:NM_001243116.1 NFKBIB
RefSeq:NM_002503.4 NFKBIB
Other Identifiers
0002650136
11725835_at
11725836_x_at
11745604_x_at
11745832_a_at
16861895
214062_3p_x_at
214062 _x_at
214448_3p_x_at
214448_x_at
228388_3p_at
228388_at
3832763
3832764
3832765
3832767
3832768
3832769
3832770
3832771
3832772
3832773
3832774
41065_at
43069_at
4793
8028552
A_23_P330895
A_23_P79086
A_24_P161086
A_33_P3343545
GE81164
GE87209
GO:0003674
GO:0003713
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0007165
去:0007253
GO:0008150
GO:0009058
GO:0034641
GO:0043226
GO:0045893
GO:0051092
GO:0071222
HMNXSV003016327
HMNXSV003028472
HMNXSV003035878
Hs.9731.0.S1_3p_a_at
Hs.9731.0.S1_3p_at
Hs.9731.0.S1_3p_x_at
Hs.9731.1.S1_3p_a_at
Hs.9731.1.S1_3p_at
Hs.9731.1.S1_3p_x_at
ILMN_1674152
ILMN_1690473
ILMN_1712754
L40407_at
PH_hs_0030976
TC19000534.hg
TC19002129.hg
Participates
as a member of
p-IKB alpha,beta,epsilon [cytosol] (Homo sapiens)
Phospho-NF-kappaB Inhibitor [cytosol] (Homo sapiens)
Other forms of this molecule
p-S19,S23-Ub-NFKBIB [cytosol]
NFKBIB [cytosol]
Inferred To
phospho-NFKBIB [cytosol]
(Canis familiaris)
phospho-NFKBIB [cytosol]
(Sus scrofa)
phospho-Nfkbib [cytosol]
(Mus musculus)
phospho-Nfkbib [cytosol]
(鼠形)
修改后的残留物
Name
O-phospho-L-serine at 19
Coordinate
19
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 23
Coordinate
23
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001230045.1
,
NP_002494.2
OpenTargets
ENSG00000104825
GeneCards
Q15653
HPA
ENSG00000104825-NFKBIB
Ensembl
ENST00000572515
,
ENSP00000489138
,
ENST00000635517
,
ENSP00000312988
,
ENST00000634647
,
ENSG00000104825
,
ENSG00000282905
,
ENST00000313582
,
ENSP00000489145
,
ENSP00000459728
PRO
Q15653
Pharos - Targets
Q15653
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
0.75
6
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