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Our Logo
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Privacy Notice
Disclaimer
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Table of Contents
DOIs
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KMT2D [nucleoplasm]
Stable Identifier
R-HSA-1183219
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MLL2, Histone-lysine N-methyltransferase MLL2, MLL2_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA2 chromatin is activated (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA2 gene is transcribed (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1: HOXA2染色质[nucle PBX1: PKNOX1活跃oplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA3 chromatin is activated (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXA3 gene is transcribed (Homo sapiens)
MAFB HOXB1: PBX1: PKNOX1活跃HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXA2 expression (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1: HOXA2染色质[nucle PBX1: PKNOX1活跃oplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXB2 expression (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB2 chromatin is activated (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB2 gene is transcribed (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB3 chromatin is activated (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB3 gene is transcribed (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXB4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXC4 chromatin is activated (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXC4 gene is transcribed (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MAFB HOXB1: PBX1: PKNOX1活跃HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
失活of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
KMT2D [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14686 KMT2D
Gene Names
KMT2D, ALR, MLL2, MLL4
Chain
chain:1-5537
Reference Genes
BioGPS Gene:8085 KMT2D
COSMIC (genes):KMT2D KMT2D
CTD Gene:8085 KMT2D
dbSNP Gene:8085 KMT2D
ENSEMBL:ENSG00000167548 KMT2D
HGNC:7133 KMT2D
KEGG Gene (Homo sapiens):8085 KMT2D
Monarch:8085 KMT2D
NCBI Gene:8085 KMT2D
OMIM:602113 KMT2D
UCSC:O14686 KMT2D
Reference Transcript
RefSeq:NM_003482.3 KMT2D
RefSeq:XM_005269162.4 KMT2D
RefSeq:XM_006719614.3 KMT2D
Other Identifiers
0006020286
11743695_at
11748924_a_at
16764160
211790_s_at
227527_at
227528_s_at
231974_at
3453585
3453586
3453587
3453588
3453589
3453590
3453591
3453593
3453594
3453595
3453596
3453597
3453598
3453601
3453602
3453605
3453606
3453608
3453610
3453611
3453612
3453613
3453615
3453619
3453620
3453621
3453622
3453623
3453624
3453625
3453626
3453627
3453628
3453629
3453630
3453631
3453632
3453633
3453634
3453635
3453636
3453637
3453638
3453639
3453640
3453643
3453644
3453645
3453646
3453647
3453648
3453649
3453650
3453651
3453652
3453653
3453654
3453655
3453656
3453657
3453658
3453659
3453660
3453661
3453662
3453663
3453664
3453665
3453666
3453668
3453669
3453670
3453671
3453672
3453673
3453674
3453675
3453676
3453677
3453678
3453679
3453680
3453682
3453683
3453685
3453687
3453688
3453689
3453690
3453691
3453692
3453693
3453694
3453695
3453696
3453698
3453699
3453700
3453701
3453702
3453703
3453704
3453705
3453706
3453708
3453709
3453713
38165_s_at
38166_r_at
64110_at
7962951
8085
A_23_P13711
A_24_P212559
A_33_P3340254
GE81286
GO:0000003
GO:0000976
GO:0001555
GO:0002376
GO:0003674
GO:0003677
GO:0003713
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006325
GO:0006342
GO:0006355
GO:0006464
GO:0007165
GO:0008150
GO:0008168
GO:0008283
GO:0008284
GO:0009058
GO:0016740
GO:0022607
GO:0030154
GO:0032259
GO:0032991
GO:0033148
GO:0034641
GO:0035097
GO:0040007
GO:0042393
GO:0042800
GO:0043167
GO:0043226
GO:0043627
GO:0044648
GO:0044666
GO:0045652
GO:0045944
GO:0046872
GO:0048477
GO:0048856
GO:0051276
GO:0051568
GO:0065003
GO:0080182
GO:0097692
GO:1904837
HMNXSV003050202
Hs.3640.0.S1_3p_a_at
Hs.3640.0.S1_3p_at
Hs.3640.1.A1_3p_at
ILMN_1802743
PH_hs_0024422
TC12003277.hg
g2358286_3p_a_at
Participates
as a member of
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
KMT2C,D [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of SET1 methyltransferase complex (Homo sapiens)
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
as a component of
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
Inferred To
KMT2D [nucleoplasm]
(Bos taurus)
KMT2D [nucleoplasm]
(Canis familiaris)
KMT2D [nucleoplasm]
(Gallus gallus)
Ghost homologue of KMT2D [nucleoplasm]
(Danio rerio)
Ghost homologue of KMT2D [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of KMT2D [nucleoplasm]
(Sus scrofa)
Ghost homologue of KMT2D [nucleoplasm]
(Xenopus tropicalis)
set-16 [nucleoplasm]
(Caenorhabditis elegans)
Kmt2d [nucleoplasm]
(Mus musculus)
trr [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_006719677.1
,
XP_005269219.1
,
NP_003473.3
Guide to Pharmacology - Targets
2691
OpenTargets
ENSG00000167548
ZINC target
O14686
PRO
O14686
GlyGen
O14686
PDB
4Z4P
,
4ERQ
,
6O7G
,
3UVK
GeneCards
O14686
HPA
ENSG00000167548-KMT2D
Ensembl
ENSP00000301067
,
ENSG00000167548
,
ENST00000301067
Pharos - Targets
O14686
Orphanet
19312
HMDB Protein
HMDBP09019
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.847
9
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.812
9
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.725
9
UniProt:Q6ZW49 PAXIP1
1
PAXIP1(核浆)
(R-HSA-5619395)
0.643
8
UniProt:O15550 KDM6A
1
KDM6A [nucleoplasm]
(R-HSA-4754224)
0.527
7
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.527
5
UniProt:Q6NZQ4 Paxip1
2
Paxip1 [nucleoplasm]
(R-MMU-5619395)
Paxip1 [nucleoplasm]
(R-MMU-5619398)
0.527
3
UniProt:Q9BTK6 PAGR1
1
PAGR1 [nucleoplasm]
(R-HSA-5619374)
0.527
3
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.525
3
UniProt:P10275 AR
4
SUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.499
2
UniProt:Q9UBL3-3 ASH2L
0.499
2
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