Reactome | vamp3 [plasma membrane]

vamp3 [plasma membrane]

Stable Identifier

R-DRE-8867599

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

VAMP3, Q6IQK3

Locations in the PathwayBrowser

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Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - 扣蛋白质和货物被雇来nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - PICALM binds R-SNAREs (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        VAMP2,3,8 [plasma membrane] (Danio rerio)
        
        vamp3 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6IQK3

Gene Names

vamp3

Reference Genes

BioGPS Gene:415163 vamp3

ENSEMBL:ENSDARG00000070161

KEGG Gene (Danio rerio):415163 vamp3

Monarch:415163 vamp3

NCBI Gene:415163 vamp3

Reference Transcript

Other Identifiers

12976171

415163

A_15_P116344

A_15_P180176

A_15_P638337

A_15_P706508

BC071402.1

CUST_1767_PI428451953

CUST_5695_PI428451958

DRER16175

DRER33554

DRER36654

Dr.5589.1.S1_at

ENSDART00000102688_x_1

ENSDART00000102688_x_2

ENSDART00000102734

ENSDART00000102734_x_1

ENSDART00000102734_x_2

GO:0003674

GO:0005484

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006906

GO:0008150

GO:0016020

GO:0016021

GO:0016192

GO:0017075

GO:0019905

GO:0022607

GO:0030674

GO:0031201

GO:0032991

GO:0035493

GO:0061024

GO:0065003

GT_Xhyb_NM_001002073.1_327205

GT_Xhyb_XM_005155905.1_397605

LOLS13737

MADDr01009286

NM_001002073

OTTDART00000029148

Participates

as a member of

VAMP2,3,8 [plasma membrane] (Danio rerio)

as a candidate of

Other forms of this molecule

vamp3 [clathrin-coated endocytic vesicle membrane]

vamp3 [transport vesicle]

vamp3 [trans-Golgi network membrane]

vamp3 [phagocytic vesicle membrane]

vamp3 [recycling endosome membrane]

Inferred From

VAMP3 [plasma membrane](Homo sapiens)

Cross References

RefSeq

NP_001002073.1,XP_005155962.1

Ensembl

ENSDARG00000070161,ENSDART00000187653,ENSDARP00000114025,ENSDARP00000145619,ENSDART00000137516

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