Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Prosbeta2 [cytosol]
Stable Identifier
R-DME-68759
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
PSMB7, Q9VUJ1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
p53-Independent G1/S DNA damage checkpoint (Drosophila melanogaster)
p53-Independent DNA Damage Response (Drosophila melanogaster)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Separation of Sister Chromatids (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Securin (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Ubiquitin-dependent degradation of Cyclin D (Drosophila melanogaster)
Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
Regulation of HMOX1 expression and activity (Drosophila melanogaster)
ROS sensing by NFE2L2 (Drosophila melanogaster)
26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
DNA Replication Pre-Initiation (Drosophila melanogaster)
Assembly of the pre-replicative complex (Drosophila melanogaster)
CDT1 association with the CDC6:ORC:origin complex (Drosophila melanogaster)
Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Drosophila melanogaster)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing-Cross presentation (Drosophila melanogaster)
Cross-presentation of soluble exogenous antigens (endosomes) (Drosophila melanogaster)
Proteasomal clevage of exogenous antigen (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Proteasomal cleavage of substrate (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
信号由B细胞受体(BCR)(果蝇melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
Ubiquitinated IkB is degraded (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
TNFR2非规范NF-kB通路(果蝇梅拉nogaster)
NIK-->noncanonical NF-kB signaling (Drosophila melanogaster)
26 s蛋白酶体过程p-7S-p100: RELB p52:RELB (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Dectin-1 mediated noncanonical NF-kB signaling (Drosophila melanogaster)
26 s蛋白酶体过程p-7S-p100: RELB p52:RELB (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of polyamines (Drosophila melanogaster)
Regulation of ornithine decarboxylase (ODC) (Drosophila melanogaster)
26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Drosophila melanogaster)
AUF1:mRNA complex is destroyed (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
UCH proteinases (Drosophila melanogaster)
ADRM1 binds 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome:UCHL5 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome:USP14 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Hedgehog 'on' state (Drosophila melanogaster)
ub-GLI is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
PCP/CE pathway (Drosophila melanogaster)
Asymmetric localization of PCP proteins (Drosophila melanogaster)
PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Degradation of AXIN (Drosophila melanogaster)
Ub-RibC-AXIN is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Degradation of DVL (Drosophila melanogaster)
Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Prosbeta2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VUJ1 Prosbeta2
Gene Names
Prosbeta2, Pros-beta-2, CG3329, Dmel_CG3329
Reference Genes
BioGPS Gene:39628 Prosbeta2
CTD Gene:39628 Prosbeta2
KEGG Gene (Drosophila melanogaster):Dmel_CG3329 Prosbeta2
Monarch:39628 Prosbeta2
NCBI Gene:39628 Prosbeta2
Reference Transcript
RefSeq:NM_079352.4 Prosbeta2
Other Identifiers
155056_at
1640608_at
39628
GO:0000502
GO:0003674
GO:0004175
GO:0004298
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0007165
GO:0007623
GO:0008063
GO:0008150
GO:0008233
GO:0009056
GO:0010498
GO:0010499
GO:0016787
GO:0019774
GO:0023052
GO:0032991
GO:0043161
GO:0043226
GO:0051603
Participates
as a component of
26S proteasome [cytosol] (Drosophila melanogaster)
Other forms of this molecule
PROSbeta2 [nucleoplasm]
PROSbeta2 [cytosol]
Prosbeta2 [secretory granule lumen]
Prosbeta2 [extracellular region]
Prosbeta2 [ficolin-1-rich granule lumen]
Prosbeta2 [nucleoplasm]
Prosbeta2 [nucleoplasm]
Prosbeta2 [cytosol]
Inferred From
PSMB7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524076.2
Flybase
FBgn0023174
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text