The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PDGF:Phospho-PDGF receptor dimer:PLC-gamma Reactome DB_ID: 9968354 plasma membrane GENE ONTOLOGY GO:0005886 PLCG1 PLCG1 A0A5F4BY78 Reactome DB_ID: 9968352 UniProt:A0A5F4BY78 PLCG1 Canis familiaris NCBI Taxonomy 9615 UniProt A0A5F4BY78 2 EQUAL 1290 EQUAL Reactome Database ID Release 77 9968352 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968352 Reactome R-CFA-167682 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167682.1 Reactome //www.joaskin.com 1 PDGF:Phospho-PDGF receptor dimer Reactome DB_ID: 9968348 Converted from EntitySet in Reactome Active PDGF dimers (AA, AB, BB) Reactome DB_ID: 9968346 active PDGF-AA dimer Reactome DB_ID: 9968334 extracellular region GENE ONTOLOGY GO:0005576 PDGFA PDGFA-1 A0A5F4CL04 Reactome DB_ID: 9968330 UniProt:A0A5F4CL04 PDGFA UniProt A0A5F4CL04 87 EQUAL 211 EQUAL Reactome Database ID Release 77 9968330 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968330 Reactome R-CFA-184199 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-184199.1 2 Reactome Database ID Release 77 9968334 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968334 Reactome R-CFA-380761 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380761.1 active PDGF-BB dimer Reactome DB_ID: 9968342 PDGFB PDGFB (82-190) A0A5F4CP81 Reactome DB_ID: 9968338 UniProt:A0A5F4CP81 PDGFB UniProt A0A5F4CP81 82 EQUAL 190 EQUAL Reactome Database ID Release 77 9968338 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968338 Reactome R-CFA-184201 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-184201.1 2 Reactome Database ID Release 77 9968342 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968342 Reactome R-CFA-184206 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-184206.1 PDGF A/B heterodimer Reactome DB_ID: 9968344 PDGFA PDGFA-2 A0A5F4CL04 Reactome DB_ID: 9968332 87 EQUAL 196 EQUAL Reactome Database ID Release 77 9968332 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968332 Reactome R-CFA-380739 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380739.1 1 1 Reactome Database ID Release 77 9968344 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968344 Reactome R-CFA-380759 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380759.1 Reactome Database ID Release 77 9968346 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968346 Reactome R-CFA-380760 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-380760.1 1 Phospho-alpha receptor homodimer Reactome DB_ID: 9968326 A0A5F4DL79 phospho-PDGFRA p-11Y-PDGFRA Reactome DB_ID: 9968324 UniProt:A0A5F4DL79 PDGFRA UniProt A0A5F4DL79 1018 EQUAL O4'-phospho-L-tyrosine MOD MOD:00048 572 EQUAL 574 EQUAL 720 EQUAL 731 EQUAL 742 EQUAL 754 EQUAL 762 EQUAL 768 EQUAL 988 EQUAL 849 EQUAL 24 EQUAL 1089 EQUAL Reactome Database ID Release 77 9968324 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968324 Reactome R-CFA-186806 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-186806.1 2 Reactome Database ID Release 77 9968326 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968326 Reactome R-CFA-186816 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-186816.1 1 Reactome Database ID Release 77 9968348 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968348 Reactome R-CFA-186811 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-186811.1 1 Reactome Database ID Release 77 9968354 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968354 Reactome R-CFA-186795 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-186795.1 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 cytosol GENE ONTOLOGY GO:0005829 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 113592 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 additional information MI MI:0361 4 PDGF:p-PDGFR dimer:p-PLCgamma Reactome DB_ID: 9995884 p-4Y-PLCG1 phospho-PLCG1 A0A5F4BY78 Reactome DB_ID: 9972374 472 EQUAL 771 EQUAL 783 EQUAL 1253 EQUAL 2 EQUAL 1290 EQUAL Reactome Database ID Release 77 9972374 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9972374 Reactome R-CFA-167679 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167679.1 1 1 Reactome Database ID Release 77 9995884 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9995884 Reactome R-CFA-1524184 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1524184.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 4 ACTIVATION GENE ONTOLOGY GO:0004713 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 9995887 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9995887 Reactome Database ID Release 77 9995889 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9995889 Reactome R-CFA-1524186 1 Reactome稳定的标识符. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1524186.1 The activated PDGF receptor phosphorylates PLCgamma on tyrosine residues 472,771,783 and 1254, activating the enzyme. 2472219 Pubmed 1989 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro Meisenhelder, J Suh, PG Rhee, SG Hunter, Tony Cell 57:1109-22 10579907 Pubmed 1999 Phospholipase C-gamma as a signal-transducing element Carpenter, G Ji, Q Exp Cell Res 253:15-24 inferred from electronic annotation EVIDENCE CODE ECO:0000203