The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp TPNH NADPH Reactome DB_ID: 29364 cytosol GENE ONTOLOGY GO:0005829 NADPH [ChEBI:16474] NADPH TPNH ChEBI CHEBI:16474 Reactome Database ID Release 77 29364 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29364 Reactome R-ALL-29364 2 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29364.2 Reactome //www.joaskin.com COMPOUND C00005 additional information MI 小姐:0361 BV biliverdin Reactome DB_ID: 189396 biliverdin [ChEBI:17033] biliverdin ChEBI CHEBI:17033 Reactome Database ID Release 77 189396 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=189396 Reactome R-ALL-189396 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-189396.3 COMPOUND C00500 BIL bilirubin bilirubin IXalpha Reactome DB_ID: 189386 bilirubin IXalpha [ChEBI:16990] bilirubin IXalpha ChEBI CHEBI:16990 Reactome Database ID Release 77 189386 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=189386 Reactome R-ALL-189386 4 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-189386.4 COMPOUND C00486 TPN NADP+ NADP NADP(+) Nicotinamide adenine dinucleotide phosphate beta-Nicotinamide adenine dinucleotide phosphate Triphosphopyridine nucleotide Reactome DB_ID: 29366 NADP(+) [ChEBI:18009] NADP(+) ChEBI CHEBI:18009 Reactome Database ID Release 77 29366 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29366 Reactome R-ALL-29366 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29366.3 COMPOUND C00006 ACTIVATION Converted from EntitySet in Reactome BLVRA:Zn2+,BLVRB Biliverdin reductases Reactome DB_ID: 9968656 BLVRB BLVRB A0A5F4C9W9 Reactome DB_ID: 9968648 UniProt:A0A5F4C9W9 BLVRB Canis familiaris NCBI Taxonomy 9615 UniProt A0A5F4C9W9 2 EQUAL 206 EQUAL Reactome Database ID Release 77 9968648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968648 Reactome R-CFA-189388 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-189388.1 BLVRA:Zn2+ Reactome DB_ID: 9968654 BLVRA BLVRA A0A5F4C4H6 Reactome DB_ID: 9968652 UniProt:A0A5F4C4H6 BLVRA UniProt A0A5F4C4H6 3 EQUAL 296 EQUAL Reactome Database ID Release 77 9968652 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968652 Reactome R-CFA-189390 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-189390.1 1 Zn2+ Zn++ zinc(2+) Zinc ion Zn(II) Reactome DB_ID: 29426 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI CHEBI:29105 Reactome Database ID Release 77 29426 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29426 Reactome R-ALL-29426 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29426.3 COMPOUND C00038 1 Reactome Database ID Release 77 9968654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968654 Reactome R-CFA-189378 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-189378.1 Reactome Database ID Release 77 9968656 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968656 Reactome R-CFA-189387 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-189387.1 GENE ONTOLOGY GO:0004074 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 9968657 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968657 Reactome Database ID Release 77 9968659 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968659 Reactome R-CFA-189384 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-189384.1 Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015). 25726384 Pubmed 2015 胆绿素还原酶同功酶的代谢 O'Brien, Luke Hosick, Peter A John, Kezia Stec, David E Hinds, Terry D Trends Endocrinol. Metab. 26:212-20 10620517 Pubmed 2000 Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B) Cunningham, O Gore, M G Mantle, T J Biochem. J. 345:393-9 22823425 Pubmed 2012 Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXα reductase Fu, Gang Liu, Haining Doerksen, Robert J J Phys Chem B 116:9580-94 inferred from electronic annotation EVIDENCE CODE ECO:0000203