The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Q9DBX2 phospho-Pdcl p-S18,S19,S20,S25-PDCL Reactome DB_ID: 9824411 cytosol GENE ONTOLOGY GO:0005829 UniProt:Q9DBX2 Pdcl Mus musculus NCBI Taxonomy 10090 UniProt Q9DBX2 18 EQUAL O-phospho-L-serine MOD MOD:00046 19 EQUAL 20 EQUAL 25 EQUAL 2 EQUAL 301 EQUAL Reactome Database ID Release 77 9824411 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9824411 Reactome R-MMU-6814228 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814228.1 Reactome //www.joaskin.com Unfolded G-protein beta subunit:CCT/TRiC:ADP Reactome DB_ID: 9824395 CCT/TRiC:ADP Reactome DB_ID: 9761992 Cct7 CCT7 P80313 Reactome DB_ID: 9761972 UniProt:P80313 Cct7 UniProt P80313 1 EQUAL 543 EQUAL Reactome Database ID Release 77 9761972 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761972 Reactome R-MMU-390451 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390451.1 1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 additional information MI MI:0361 8 Tcp1 TCP1 P11983 Reactome DB_ID: 9761956 UniProt:P11983 Tcp1 UniProt P11983 1 EQUAL 556 EQUAL Reactome Database ID Release 77 9761956 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761956 Reactome R-MMU-390448 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390448.1 1 Converted from EntitySet in Reactome CCT6 CCT6A,(CCT6B) CCT6A,CCT6B Reactome DB_ID: 9761990 Cct6a CCT6A P80317 Reactome DB_ID: 9761984 UniProt:P80317 Cct6a UniProt P80317 2 EQUAL 531 EQUAL Reactome Database ID Release 77 9761984 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761984 Reactome R-MMU-390454 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390454.1 Cct6b CCT6B Q61390 Reactome DB_ID: 9761988 UniProt:Q61390 Cct6b UniProt Q61390 1 EQUAL 530 EQUAL Reactome Database ID Release 77 9761988 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761988 Reactome R-MMU-5216201 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5216201.1 Reactome Database ID Release 77 9761990 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761990 Reactome R-MMU-6813612 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6813612.1 1 Cct3 CCT3 P80318 Reactome DB_ID: 9761976 UniProt:P80318 Cct3 UniProt P80318 1 EQUAL 545 EQUAL Reactome Database ID Release 77 9761976 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761976 Reactome R-MMU-390463 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390463.1 1 Cct5 CCT5 P80316 Reactome DB_ID: 9761968 UniProt:P80316 Cct5 UniProt P80316 2 EQUAL 541 EQUAL Reactome Database ID Release 77 9761968 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761968 Reactome R-MMU-390447 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390447.1 1 Cct4 CCT4 P80315 Reactome DB_ID: 9761964 UniProt:P80315 Cct4 UniProt P80315 2 EQUAL 539 EQUAL Reactome Database ID Release 77 9761964 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761964 Reactome R-MMU-390458 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390458.1 1 Cct2 CCT2 P80314 Reactome DB_ID: 9761960 UniProt:P80314 Cct2 UniProt P80314 2 EQUAL 535 EQUAL Reactome Database ID Release 77 9761960 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761960 Reactome R-MMU-390464 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390464.1 1 Cct8 CCT8 P42932 Reactome DB_ID: 9761980 UniProt:P42932 Cct8 UniProt P42932 2 EQUAL 548 EQUAL Reactome Database ID Release 77 9761980 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761980 Reactome R-MMU-390449 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390449.1 1 Reactome Database ID Release 77 9761992 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9761992 Reactome R-MMU-390455 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-390455.1 1 Converted from EntitySet in Reactome Unfolded GNB Unfolded G-protein beta subunit Reactome DB_ID: 9824393 Gnb1 G-protein beta 1 subunit GBB1_MOUSE Gnb1 Reactome DB_ID: 4551475 UniProt:P62874 Gnb1 Gnb1 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). Interacts with ARHGEF18 and RASD2 (By similarity).PTM Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62874 2 EQUAL 340 EQUAL Reactome Database ID Release 77 4551475 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4551475 Reactome R-MMU-4551475 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551475.1 Gnb2 G-protein beta 2 subunit GBB2_MOUSE Gnb2 Reactome DB_ID: 4551493 UniProt:P62880 Gnb2 Gnb2 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.DEVELOPMENTAL STAGE Expressed in meiotically incompetent oocytes. Expression increases in fully grown meiotically competent oocytes. Expression then decreases during metaphase-II arrested eggs, one-cell embryo, two-cell embryo and eight-cell embryo stages, and increases again during blastocyst stage.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62880 2 EQUAL 340 EQUAL Reactome Database ID Release 77 4551493 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4551493 Reactome R-MMU-4551493 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551493.1 Gnb3 G-protein beta 3 subunit GBB3_MOUSE Gnb3 Reactome DB_ID: 4551480 UniProt:Q61011 Gnb3 Gnb3 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity).SIMILARITY Belongs to the WD repeat G protein beta family. UniProt Q61011 1 EQUAL 340 EQUAL Reactome Database ID Release 77 4551480 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4551480 Reactome R-MMU-4551480 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551480.1 Gnb4 G-protein beta 4 subunit Guanine nucleotide-binding protein subunit beta-4 GBB4_MOUSE Gnb4 Reactome DB_ID: 4551495 UniProt:P29387 Gnb4 Gnb4 FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P29387 2 EQUAL 340 EQUAL Reactome Database ID Release 77 4551495 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4551495 Reactome R-MMU-4551495 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551495.1 Gnb5 G-protein beta 5 subunit Guanine nucleotide-binding protein subunit beta-5 GBB5_MOUSE Gnb5 Reactome DB_ID: 4551482 UniProt:P62881 Gnb5 Gnb5 FUNCTION Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).SUBUNIT Component of a complex composed of RGS9, GNB5 and RGS9BP; within this complex, the presence of GNB5 stabilizes both itself and RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By similarity) (PubMed:12119397, PubMed:16908407, PubMed:18204463). Interacts with RGS6 and RGS7 (By similarity).TISSUE SPECIFICITY Isoform 1 is only detected in retina (PubMed:8910430). Isoform 2 is detected in brain (at protein level) (PubMed:8071339). Isoform 2 is detected in brain (PubMed:8071339).SIMILARITY Belongs to the WD repeat G protein beta family. UniProt P62881 1 EQUAL 395 EQUAL Reactome Database ID Release 77 4551482 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4551482 Reactome R-MMU-4551482 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-4551482.1 Reactome Database ID Release 77 9824393 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9824393 Reactome R-MMU-6814207 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814207.1 1 Reactome Database ID Release 77 9824395 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9824395 Reactome R-MMU-6814211 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814211.1 p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP Reactome DB_ID: 9824413 1 1 Reactome Database ID Release 77 9824413 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9824413 Reactome R-MMU-6814234 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814234.1 Reactome Database ID Release 77 9824415 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9824415 Reactome R-MMU-6814121 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6814121.1 PDCL (PhLP1), phosphorylated by the casein kinase II complex (CK2), simultaneously binds to the unfolded G-protein beta subunit and the TRiC/CCT chaperonin (Lukov et al. 2005, Lukov et al. 2006, Plimpton et al. 2015). Phosphorylation is not a prerequisite for PDCL binding to TRiC/CCT and the unfolded G-protein beta, but is necessary for PDCL-mediated release of folded G-protein beta from TRiC/CCT (Lukov et al. 2006). 16717095 Pubmed 2006 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex Lukov, Georgi L Baker, Christine M Ludtke, Paul J Hu, Ting Carter, Michael D Hackett, Ryan A Thulin, Craig D Willardson, Barry M J. Biol. Chem. 281:22261-74 15889144 Pubmed 2005 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly Lukov, Georgi L Hu, Ting McLaughlin, Joseph N Hamm, Heidi E Willardson, Barry M EMBO J. 24:1965-75 25675501 Pubmed 2015 Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly Plimpton, Rebecca L Cuellar, Jorge Lai, Chun Wan J Aoba, Takuma Makaju, Aman Franklin, Sarah Mathis, Andrew D Prince, John T Carrascosa, José L Valpuesta, Jose M Willardson, Barry M Proc. Natl. Acad. Sci. U.S.A. 112:2413-8 inferred from electronic annotation EVIDENCE CODE ECO:0000203