The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome C-terminal EH domain containing proteins Reactome DB_ID: 9776528 Ehd1 EHD1 Q9WVK4 Reactome DB_ID: 9776518 endosome membrane GENE ONTOLOGY GO:0010008 UniProt:Q9WVK4 Ehd1 Mus musculus NCBI Taxonomy 10090 UniProt Q9WVK4 1 EQUAL 534 EQUAL Reactome Database ID Release 77 9776518 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776518 Reactome R-MMU-1011616 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011616.1 Reactome //www.joaskin.com Ehd2 EHD2 Q8BH64 Reactome DB_ID: 9776522 UniProt:Q8BH64 Ehd2 UniProt Q8BH64 1 EQUAL 543 EQUAL Reactome Database ID Release 77 9776522 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776522 Reactome R-MMU-1011594 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011594.1 Ehd3 EHD3 Q9QXY6 Reactome DB_ID: 9776526 UniProt:Q9QXY6 Ehd3 UniProt Q9QXY6 1 EQUAL 535 EQUAL Reactome Database ID Release 77 9776526 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776526 Reactome R-MMU-1011601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011601.1 Reactome Database ID Release 77 9776528 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776528 Reactome R-MMU-1011595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011595.1 Rbsn ZFYVE20 Q80Y56 Reactome DB_ID: 9746892 UniProt:Q80Y56 Rbsn UniProt Q80Y56 1 EQUAL 784 EQUAL Reactome Database ID Release 77 9746892 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9746892 Reactome R-MMU-188000 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-188000.1 C-terminal EH domain containing proteins:Rabenosyn-5 Reactome DB_ID: 9776530 1 1 Reactome Database ID Release 77 9776530 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776530 Reactome R-MMU-1011577 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011577.1 Reactome Database ID Release 77 9776532 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9776532 Reactome R-MMU-1011576 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1011576.1 The four human EH domain-containing proteins (EHD1-4) are a distinct highly-homologous subfamily of the Eps15-homology (EH) domain family. They are distinct from most other EH family members in having the EH-domain at the C-terminus (Naslavsky & Caplan 2005). EH domains interact with other proteins; peptides containing Asp-Pro-Phe (NPF) motifs are major targets for EH-domain binding (Salcini et al. 1997). EH domain family proteins have regulatory roles in endocytic membrane transport events (Naslavsky & Caplan 2005); the EHD subfamily is believed to regulate endocytic recycling (George et al. 2007). All four human EHD proteins can rescue the vacuolated intestinal phenotype observed when the C. elegans orthologue rme-1 is mutated (George et al. 2007). Over 20 interaction partners have been reported for the C-terminal EHD proteins including clathirin, syndaptins and Arp2/3 (see Naslavsky & Caplan 2005). EHD1-3 all interact with Rabenosyn-5 (Rab5), a Rab5 effector (Naslavsky et al. 2004). 15020713 Pubmed 2004 Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane Naslavsky, N Boehm, M Backlund PS, Jr Caplan, S Mol Biol Cell 15:2410-22 9303539 Pubmed 1997 结合特异性和体内t的目标he EH domain, a novel protein-protein interaction module Salcini, AE Confalonieri, S Doria, M Santolini, E Tassi, E Minenkova, O Cesareni, G Pelicci, PG Di Fiore, PP Genes Dev 11:2239-49 17233914 Pubmed 2007 Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans George, M Ying, G Rainey, MA Solomon, A Parikh, PT Gao, Q Band, V Band, H BMC Cell Biol 8:3 16155252 Pubmed 2005 C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? Naslavsky, N Caplan, S J Cell Sci 118:4093-101 inferred from electronic annotation EVIDENCE CODE ECO:0000203