BioPAX pathway converted from "Expression of IL4,IL13-downregulated extracellular genes" in the Reactome database. LEFT-TO-RIGHT Expression of IL4,IL13-downregulated extracellular genes In human peripheral blood, monocytes Interleukin-4 (IL4) and Interleukin-13 significantly downregulate the expression of classical proinflammatory signal transducers, such as Interleukin-1 (IL1), Interleukin-6, Interleukin-8, Interleukin-18, C-C motif chemokine 2 (CCL2) and Tumor necrosis factor (TNF). Expression of Prostaglandin G/H synthase 2 (PTGS2, COX2) and Arachidonate 5-lipoxygenase (ALOX5), enzymes involved in the biosynthesis of the proinflammatory eicosanoids, is also attenuated (Chatidis et al. 2005).
This is a black box event because the mechanism of gene regulation is not fully defined. Authored: Jupe, Steve, 2015-07-01 综述:Leibovich,撒母耳,2016-09-02 Edited: Jupe, Steve, 2016-09-02 Converted from EntitySet in Reactome IL4,IL13-downregulated genes for extracellular proteins Reactome DB_ID: 6789520 IL1A gene Reactome DB_ID: 4568733 nucleoplasm GENE ONTOLOGY GO:0005654 ENSEMBL:ENSG00000115008 IL1A IL1A IL1F1 Homo sapiens NCBI Taxonomy 9606 ENSEMBL ENSG00000115008 Reactome Database ID Release 77 4568733 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=4568733 Reactome rhSA-4568733 2 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-4568733.2 Reactome //www.joaskin.com IL1B gene Reactome DB_ID: 5661000 ENSEMBL:ENSG00000125538 IL1B IL1B gene IL1B IL1F2 ENSEMBL ENSG00000125538 Reactome Database ID Release 77 5661000 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=5661000 Reactome r - hsa - 5661000 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5661000.1 TNF gene Reactome DB_ID: 6785015 运用:ENSG00000232810肿瘤坏死因子 TNF TNFA TNFSF2 ENSEMBL ENSG00000232810 Reactome Database ID Release 77 6785015 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6785015 Reactome rhSA-6785015 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6785015.1 IL6 gene Reactome DB_ID: 3788729 ENSEMBL:ENSG00000136244 IL6 IL6 IFNB2 ENSEMBL ENSG00000136244 Reactome Database ID Release 77 3788729 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3788729 Reactome rhSA-3788729 2 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3788729.2 CCL2 gene Reactome DB_ID: 5642238 ENSEMBL:ENSG00000108691 CCL2 CCL2 MCP1 SCYA2 ENSEMBL ENSG00000108691 Reactome Database ID Release 77 5642238 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=5642238 Reactome rhSA-5642238 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5642238.1 IL8 gene CXCL8 gene Reactome DB_ID: 3788737 ENSEMBL:ENSG00000169429 IL8 IL8 CXCL8 ENSEMBL ENSG00000169429 Reactome Database ID Release 77 3788737 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=3788737 Reactome rhSA-3788737 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3788737.3 Reactome Database ID Release 77 6789520 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6789520 Reactome rhSA-6789520 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6789520.3 Converted from EntitySet in Reactome IL4,IL13-downregulated extracellular proteins Reactome DB_ID: 6789485 IL1A Myr82K-Myr83K-IL1A 2xMyri-IL1A Interleukin-1 alpha IL1A_HUMAN Reactome DB_ID: 445746 extracellular region GENE ONTOLOGY 去:0005576 UniProt:P01583 IL1A IL1A IL1F1 FUNCTION Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.SUBUNIT Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).DOMAIN The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.SIMILARITY Belongs to the IL-1 family. UniProt P01583 82 EQUAL N6-myristoyl-L-lysine MOD MOD:00087 83 EQUAL 113 EQUAL 271 EQUAL Reactome Database ID Release 77 445746 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=445746 Reactome rhSA-445746 2 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445746.2 IL1B Interleukin-1 beta IL1B_HUMAN Reactome DB_ID: 445748 UniProt:P01584 IL1B IL1B IL1F2 FUNCTION Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).SUBUNIT Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422). Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430). Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form (PubMed:32272059). Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059). Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059).TISSUE SPECIFICITY Expressed in activated monocytes/macrophages (at protein level).INDUCTION By LPS (PubMed:15192144). Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components in macrophages; EsxA is the most potent activator tested (at protein level) (PubMed:20148899). In pancreatic islets, release is increased by high glucose treatment. In pancreatic islets and macrophages, release is also increased by endocannabinoid anandamide/AEA (PubMed:23955712).PTM Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.MISCELLANEOUS The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.SIMILARITY Belongs to the IL-1 family. UniProt P01584 117 EQUAL 269 EQUAL Reactome Database ID Release 77 445748 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=445748 Reactome rhSA-445748 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-445748.1 IL6 Interleukin-6 IL6_HUMAN Reactome DB_ID: 447100 UniProt:P05231 IL6 IL6 IFNB2 FUNCTION Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).FUNCTION IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).FUNCTION Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).SUBUNIT Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785). Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003). Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).TISSUE SPECIFICITY Produced by skeletal muscle.INDUCTION Plasma levels are highly increased upon exercise, due to enhanced production by contracting skeletal muscles.PTM N- and O-glycosylated.POLYMORPHISM Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.DISEASE A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.SIMILARITY Belongs to the IL-6 superfamily. UniProt P05231 30 EQUAL 212 EQUAL Reactome Database ID Release 77 447100 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=447100 Reactome r - hsa - 447100 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447100.1 IL8 Interleukin-8 IL8_HUMAN CXCL8 Reactome DB_ID: 447095 UniProt:P10145 CXCL8 CXCL8 IL8 FUNCTION IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.SUBUNIT Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521).INDUCTION By ER stress in a DDIT3/CHOP-dependent manner.PTM Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.PTM Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.SIMILARITY Belongs to the intercrine alpha (chemokine CxC) family. UniProt P10145 23 EQUAL 99 EQUAL Reactome Database ID Release 77 447095 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=447095 Reactome rhSA-447095 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447095.1 CCL2 C-C motif chemokine 2 CCL2_HUMAN Reactome DB_ID: 443967 UniProt:P13500 CCL2 CCL2 MCP1 SCYA2 FUNCTION Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).SUBUNIT Monomer or homodimer; in equilibrium (PubMed:8898111, PubMed:9837883, PubMed:15033992, PubMed:8989326). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674).TISSUE SPECIFICITY Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477).INDUCTION Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712).PTM Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).PTM N-Glycosylated.POLYMORPHISM Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].SIMILARITY Belongs to the intercrine beta (chemokine CC) family. UniProt P13500 24 EQUAL 99 EQUAL Reactome Database ID Release 77 443967 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=443967 Reactome rhSA-443967 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-443967.1 TNF TNF(77-233) TNF-alpha Tumor necrosis factor TNFA_HUMAN Cachectin Reactome DB_ID: 976821 UniProt:P01375 TNF TNF TNFA TNFSF2 功能的细胞因子,结合TNFRSF1A / TNFR1和TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819).FUNCTION The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.SUBUNIT Homotrimer. Interacts with SPPL2B.PTM The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.PTM The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.PTM O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.POLYMORPHISM Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].POLYMORPHISM Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162].SIMILARITY Belongs to the tumor necrosis factor family. UniProt P01375 77 EQUAL 233 EQUAL Reactome Database ID Release 77 976821 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=976821 Reactome rhSA-976821 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-976821.3 Reactome Database ID Release 77 6789485 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6789485 Reactome rhSA-6789485 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6789485.1 Reactome Database ID Release 77 6789524 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6789524 Reactome rhSA-6789524 3 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6789524.3 15869882 Pubmed 2005 Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13 Chaitidis, Pavlos O'Donnell, Valerie Kuban, Ralf J Bermudez-Fajardo, Alexandra Ungethuem, Ute Kühn, Hartmut Cytokine 30:366-77 INHIBITION Reactome Database ID Release 77 9031546 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9031546 Reactome rhSA-9031546 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9031546.1 Converted from EntitySet in Reactome IL4, IL13 Reactome DB_ID: 6797283 IL13 Interleukin-13 IL13_HUMAN Reactome DB_ID: 447211 UniProt:P35225 IL13 IL13 NC30 功能细胞因子(PubMed PubMed: 8096327: 8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).SUBUNIT Interacts with IL13RA2.SIMILARITY Belongs to the IL-4/IL-13 family.CAUTION It is uncertain whether Met-1 or Met-15 is the initiator. UniProt P35225 25 EQUAL 146 EQUAL Reactome Database ID Release 77 447211 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=447211 Reactome rhSA-447211 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447211.1 IL4 Interleukin-4 IL4_HUMAN Reactome DB_ID: 447110 UniProt:P05112 IL4 IL4 FUNCTION Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).SIMILARITY Belongs to the IL-4/IL-13 family. UniProt P05112 25 EQUAL 153 EQUAL Reactome Database ID Release 77 447110 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=447110 Reactome rhSA-447110 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-447110.1 Reactome Database ID Release 77 6797283 数据库identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6797283 Reactome rhSA-6797283 1 Reactome稳定的标识符。使用这个URL connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6797283.1