BioPAX pathway converted from "Transport of Connexin to the Trans-Golgi network" in the Reactome database.
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Transport of Connexin to the Trans-Golgi network
Transport of connexins along the secretory pathway (including transit from the Golgi to the TGN where Cx43 is predicted to oligomerize) occurs in vesicular transport containers.
Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09
Edited: Matthews, L, 2007-01-07 14:51:44
Cx43
Reactome DB_ID: 190688
endoplasmic reticulum membrane
GENE ONTOLOGY
去:0005789
UniProt:P08050 Gja1
Gja1
Cxn-43
FUNCTION Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity).SUBUNIT A connexon is composed of a hexamer of connexins (PubMed:1371548). Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1 (PubMed:15492000, PubMed:18636092). Interacts (via C-terminus) with SRC (via SH3 domain) (PubMed:15492000). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (PubMed:20127391). Interacts with NOV (PubMed:15181016, PubMed:15213231). Interacts with TMEM65 (By similarity).TISSUE SPECIFICITY Detected in ventricle and atrium (at protein level).INDUCTION In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-8 (at protein level). Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level).PTM Contains at least one intramolecular disulfide bond.PTM Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (PubMed:24500718).PTM Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).PTM S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.PTM Acetylated in the developing cortex; leading to delocalization from the cell membrane.SIMILARITY Belongs to the connexin family. Alpha-type (group II) subfamily.
Rattus norvegicus
NCBI Taxonomy
10116
UniProt
P08050
Reactome Database ID Release 77
190688
Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190688
Reactome
R-RNO-190688
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-190688.1
Reactome
//www.joaskin.com
6
Connexin 43
Reactome DB_ID: 190650
Golgi membrane
GENE ONTOLOGY
去:0000139
Reactome Database ID Release 77
190650
Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190650
Reactome
R-RNO-190650
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-190650.1
6
Reactome Database ID Release 77
190685
Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=190685
Reactome
R-RNO-190685
2
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-190685.2
7691412
Pubmed
1993
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER
Musil, LS
前言,哒
Cell 74:1065-77