在Reactome数据库中，BioPAX途径由“PI3-kinase binding to the active receptor”转化而来。 从左到右 pi3-激酶与活性受体结合 磷脂酰肌醇3'-激酶（PI3Ks）是一种可以磷酸化磷酸钠的酶系列。PI3KS与PDGF受体激活并激活。PDGFβ受体中的Tyr740和Tyr 751和PDGFα受体中的Tyr731和Tyr742已被证明是自磷酸化位点并结合PI3-激酶。
作者:Garapati, P V, Jassal, B, 2008-11-24 10:14:27 评论:Heldin, CH, 2008-11-23 19:29:34 编辑:Garapati, P V, Jassal, B, 2008-11-24 10:14:27 PDGF: Phospho-PDGF受体二聚体 Reactome DB_ID: 186811 血浆膜 基因本体论 去:0005886 从Reactome中的EntitySet转换而来 活性PDGF二聚体(AA, AB, BB) Reactome DB_ID: 380760 活跃PDGF-AA二聚体 Reactome DB_ID: 380761 细胞外区域 基因本体论 去：0005576. 从Reactome中的EntitySet转换而来 活性血小板衍生生长因子A链亚型 Reactome DB_ID: 381940 PDGFA-1 PDGFA同种型1 血小板衍生生长因子，A链亚型1 PDGF连锁 血小板衍生的生长因子-多肽 Reactome DB_ID: 184199 UniProt: P04085-1 PDGFA PDGFA PDGF1 功能生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化过程中发挥重要作用。间充质起源细胞的有效有丝分裂原。胚胎发育、胃肠道发育、间质细胞发育和精子发生所需的正常肺泡间隔。需要正常的少突胶质细胞发育和正常的脊髓和小脑髓鞘形成。在伤口愈合中起重要作用。信号传导是通过PDGFB异质二聚体的形成来调节的(通过相似性)。亚基为;反平行的disulfide-linked二聚体。与PDGFB异质二聚体;反平行的disulfide-linked二聚体。PDGFA同源二聚体与PDGFRA同源二聚体相互作用，并与PDGFRA和PDGFRB形成的异二聚体相互作用。 The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.DOMAIN The long form contains a basic insert which acts as a cell retention signal.SIMILARITY Belongs to the PDGF/VEGF growth factor family. 智人 NCBI分类法 9606 UniProt同种型 P04085-1 87. 平等的 211 平等的 反应数据库ID版本77 184199 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=184199 反应 r - hsa - 184199 1 Reactome稳定的标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-184199.1 反应 //www.joaskin.com PDGFA-2 PDGFA同种型2 血小板衍生生长因子A链亚型2 活性PDGF a链亚型2 Reactome DB_ID: 380739 UniProt: P04085-2 PDGFA PDGFA PDGF1 功能生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化过程中发挥重要作用。间充质起源细胞的有效有丝分裂原。胚胎发育、胃肠道发育、间质细胞发育和精子发生所需的正常肺泡间隔。需要正常的少突胶质细胞发育和正常的脊髓和小脑髓鞘形成。在伤口愈合中起重要作用。信号传导是通过PDGFB异质二聚体的形成来调节的(通过相似性)。亚基为;反平行的disulfide-linked二聚体。与PDGFB异质二聚体;反平行的disulfide-linked二聚体。PDGFA同源二聚体与PDGFRA同源二聚体相互作用，并与PDGFRA和PDGFRB形成的异二聚体相互作用。 The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.DOMAIN The long form contains a basic insert which acts as a cell retention signal.SIMILARITY Belongs to the PDGF/VEGF growth factor family. UniProt同种型 P04085-2 87. 平等的 196 平等的 反应数据库ID版本77 380739 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=380739 反应 R-HSA-380739 1 Reactome稳定的标识符。使用此URL连接到该实例的网页中Reactome：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-380739.1 反应数据库ID版本77 381940 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=381940 反应 r - hsa - 381940 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381940.1 2 反应数据库ID版本77 380761. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=380761 反应 r - hsa - 380761 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-380761.2 ComplexPortal CPX-1874. 额外的信息 心肌梗死 小姐:0361 活跃PDGF-BB二聚体 Reactome DB_ID: 184206 从Reactome中的EntitySet转换而来 处理PDGF-B 反应DB_ID：381935 同单晶硅 PDGFB (82 - 190) 血小板衍生生长因子，B链 PDGF B-chain 血小板衍生的生长因子-多肽 PDGF-2 Becaplermin Reactome DB_ID: 184201 UniProt: P01127 PDGFB PDGFB PDGF2 SIS. 功能生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化过程中发挥重要作用。用于间充质源性的细胞有效的丝分裂原（PubMed：26599395）。在中枢神经系统，皮肤，肺，心脏和胎盘中正常增殖和血管平滑肌细胞正常增殖和招募所需的。正常血管发育所需，以及正常发育肾盂。在伤口愈合中起重要作用。通过用PDGFA（按相似性）的异二聚体形成信号传导.subunit反平行同型二聚体;二硫化物连接。反平行异二聚体与PDGFA;二硫化物连接。PDGFB同源过二聚体与PDGFRA和PDGFRB同源体相互作用，并通过PDGFRA和PDGFRB形成的异二聚体。 The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with LRP1 (PubMed:15053742). Interacts with SORL1 (via the N-terminal ectodomain) (PubMed:15053742, PubMed:16393139).TISSUE SPECIFICITY Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.DISEASE A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.PHARMACEUTICAL Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.SIMILARITY Belongs to the PDGF/VEGF growth factor family. UniProt P01127 82. 平等的 190 平等的 反应数据库ID版本77 184201 数据库标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=184201 反应 r - hsa - 184201 2 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-184201.2 PDGFB (82 - 241) 血小板衍生生长因子，带有保留基序的B链 反应DB_ID：381904 82. 平等的 241 平等的 反应数据库ID版本77 381904 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=381904 反应 R-HSA-381904 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-381904.2 反应数据库ID版本77 381935 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=381935 反应 r - hsa - 381935 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -381935.1 2 反应数据库ID版本77 184206 数据库标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=184206 反应 r - hsa - 184206 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-184206.2 ComplexPortal CPX-1876. PDGF A / B异质二聚体 Reactome DB_ID: 380759 1 1 反应数据库ID版本77 380759. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=380759 反应 r - hsa - 380759 1 Reactome稳定的标识符。使用此URL将此实例的网页连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -380759.1 ComplexPortal CPX-1875. 反应数据库ID版本77 380760. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=380760 反应 r - hsa - 380760 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-380760.2 1 从Reactome中的EntitySet转换而来 磷酸- PDGF受体二聚体 反应DB_ID：186821 Phospho-alpha受体为 Reactome DB_ID: 186816 PDGFRA p-11Y-PDGFRA Phospho-alpha PDGF受体 pgds_human. Reactome DB_ID: 186806 UniProt: P16234 PDGFRA PDGFRA PDGFR2 RHEPDGFRA 酪氨酸蛋白激酶，作为PDGFA、PDGFB和PDGFC的细胞表面受体，在调控胚胎发育、细胞增殖、存活和趋化中发挥重要作用。根据具体情况，促进或抑制细胞增殖和细胞迁移。在骨髓间充质干细胞的分化中起重要作用。胚胎发育过程中正常的骨骼发育和头部闭合所必需的。胃肠道粘膜的正常发育、间充质细胞的补充和肠绒毛的正常发育所必需的。在伤口愈合过程中起细胞迁移和趋化作用。在血小板活化、血小板颗粒分泌激动剂和凝血酶诱导的血小板聚集中发挥作用。其同源配体-同二聚体PDGFA，同二聚体PDGFB, PDGFA和PDGFB或同二聚体PDGFC形成的异二聚体的结合导致多个信号级联的激活;这种反应取决于结合配体的性质，并由PDGFRA和PDGFRB之间异源二聚体的形成调节。磷酸化PIK3R1, PLCG1和PTPN11。 Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.ACTIVITY REGULATION Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib.SUBUNIT Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain) (By similarity). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7.SUBUNIT (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB. Interacts also with the trimeric complex gH-gL-gO.TISSUE SPECIFICITY Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue.PTM N-glycosylated.PTM Ubiquitinated, leading to its internalization and degradation.PTM Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.DISEASE A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). Mutations that cause overexpression and/or constitutive activation of PDGFRA may be a cause of hypereosinophilic syndrome.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. UniProt P16234 1018 平等的 O4的-phospho-L-tyrosine 摩擦 国防部:00048 572 平等的 574 平等的 720. 平等的 731. 平等的 742. 平等的 754 平等的 762 平等的 768 平等的 988. 平等的 849. 平等的 24 平等的 1089 平等的 反应数据库ID版本77 186806 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186806 反应 R-HSA-186806 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186806.1 2 反应数据库ID版本77 186816 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id = 186816 反应 r - hsa - 186816 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186816.1 磷酸α-磷酸β受体异二聚体 反应DB_ID：186769 PDGFRB P-12Y-PDGFRB 磷酸βPDGF受体 pgdr_human. Reactome DB_ID: 186803 UniProt的：P09619 PDGFRB PDGFRB PDGFR PDGFR1 FUNCTION酪氨酸 - 蛋白激酶充当用于同型二聚体和PDGFB PDGFD细胞表面受体以及用于通过PDGFA和PDGFB形成异源二聚体，以及在胚胎发育，细胞增殖，存活，分化，趋化和迁移的调节中起重要作用。通过促进细胞增殖，迁移和周细胞和平滑肌细胞的募集到内皮细胞中血管发育的重要作用。在血管平滑肌细胞的迁移和内膜在血管损伤部位形成的作用。需要心血管系统的正常发育。所需的周细胞正常募集（肾小球膜细胞）在肾小球，以及在肾小球毛细血管的支链网络的正常形成。促进肌动蛋白骨架的重排和膜皱褶的形成。其同源配体的结合 - 同型二聚体PDGFB，通过PDGFA和PDGFB或同型二聚体PDGFD -leads到的几个信号传导级联的激活形成的异源二聚体;这种反应取决于结合配体的性质，并由PDGFRA和PDGFRB之间异源二聚体的形成调节。磷酸PLCG1，PIK3R1，PTPN11，RASA1 / GAP，CBL，SHC1和NCK1。PLCG1导致产生的细胞信号传导分子的二酰基甘油的和1,4,5-三磷酸肌醇，动员细胞内的Ca的（2+）和蛋白的活化激活激酶C PIK3R1的磷酸化，磷脂酰肌醇的调节亚基3-激酶，通向AKT1信号传导途径的活化。 Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.ACTIVITY REGULATION Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib.SUBUNIT Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with SHB. Interacts (tyrosine phosphorylated) with PIK3R1 and RASA1. Interacts (tyrosine phosphorylated) with CBL. Interacts (tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by SHC1. Interacts (via C-terminus) with SLC9A3R1.PTM Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-579, and to a lesser degree, at Tyr-581, is important for interaction with SRC family kinases. Phosphorylation at Tyr-740 and Tyr-751 is important for interaction with PIK3R1. Phosphorylation at Tyr-751 is important for interaction with NCK1. Phosphorylation at Tyr-771 and Tyr-857 is important for interaction with RASA1/GAP. Phosphorylation at Tyr-857 is important for efficient phosphorylation of PLCG1 and PTPN11, resulting in increased phosphorylation of AKT1, MAPK1/ERK2 and/or MAPK3/ERK1, PDCD6IP/ALIX and STAM, and in increased cell proliferation. Phosphorylation at Tyr-1009 is important for interaction with PTPN11. Phosphorylation at Tyr-1009 and Tyr-1021 is important for interaction with PLCG1. Phosphorylation at Tyr-1021 is important for interaction with CBL; PLCG1 and CBL compete for the same binding site. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021. Dephosphorylated by PTPN2 at Tyr-579 and Tyr-1021.PTM N-glycosylated.PTM Ubiquitinated. After autophosphorylation, the receptor is polyubiquitinated, leading to its degradation.DISEASE A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. UniProt P09619. 1009 平等的 1021 平等的 579 平等的 581 平等的 716 平等的 740. 平等的 751 平等的 763 平等的 771 平等的 775 平等的 778 平等的 857. 平等的 33 平等的 1106 平等的 反应数据库ID版本77 186803 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186803 反应 r - hsa - 186803 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-186803.1 1 1 反应数据库ID版本77 186769 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186769 反应 r - hsa - 186769 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186769.1 Phospho-beta受体为 Reactome DB_ID: 186805 2 反应数据库ID版本77 186805 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186805 反应 R-HSA-186805 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186805.1 反应数据库ID版本77 186821 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186821 反应 r - hsa - 186821 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186821.1 1 反应数据库ID版本77 186811 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186811 反应 r - hsa - 186811 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186811.1 PI3K Reactome DB_ID: 74693 胞质 基因本体论 去:0005829 从Reactome中的EntitySet转换而来 PI3K-catalytic亚基 Reactome DB_ID: 74689 PIK3CA PI3K-p110 pi3 -激酶p110亚基 磷脂酰肌醇3-激酶催化亚基，α亚型(EC 2.7.1.137) (pi3 -激酶p110亚基)(ptdins -3-激酶p110) (PI3K) 磷脂酰肌醇-4,5-双磷酸3-激酶催化亚基，α同种型 PtdIns——3-kinase p110 Reactome DB_ID: 74787 UniProt: P42336 PIK3CA PIK3CA 磷酸肌醇-3-激酶(PI3K)磷酸化磷脂酰肌醇(PI)及其在肌醇环3位的磷酸化衍生物生成3-磷酸肌醇(PubMed:15135396, PubMed:23936502, PubMed:28676499)。使用ATP和PtdIns(4,5)P2(磷脂酰肌醇4,5-二磷酸)生成磷脂酰肌醇3,4,5-三磷酸(PIP3) (PubMed:15135396, PubMed:28676499)。PIP3通过将包含PH结构域的蛋白招募到细胞膜上，包括AKT1和PDPK1，激活涉及细胞生长、存活、增殖、运动和形态的信号级联，发挥着关键作用。参与细胞信号传导以响应各种生长因子。参与受体酪氨酸激酶配体(如EGF、胰岛素、IGF1、VEGFA和PDGF)刺激后AKT1的激活。通过胰岛素受体底物(IRS)蛋白参与信号传导。可能通过调节RhoA活性，在血管发育过程中通过VEGFA信号传导内皮细胞迁移必不可少。淋巴血管发育所需，可能通过与RAS结合和EGF和FGF2的激活，但不通过PDGF。通过PDPK1-AKT1通路调控侵袭性足的形成。通过AKT1途径参与胚胎干细胞的心肌发生。 Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:23936502, PubMed:28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).PATHWAY Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.SUBUNIT Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3) (PubMed:26593112). Interacts with IRS1 in nuclear extracts (By similarity). Interacts with RUFY3 (By similarity). Interacts with RASD2 (By similarity). Interacts with APPL1. Interacts with HRAS and KRAS (By similarity). Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (By similarity). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (PubMed:23676467).DOMAIN The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1.DISEASE PIK3CA mutations are involved in various type of cancer. Most of the cancer-associated mutations are missense mutations and map to one of the three hotspots: Glu-542; Glu-545 and His-1047. Mutated isoforms participate in cellular transformation and tumorigenesis induced by oncogenic receptor tyrosine kinases (RTKs) and HRAS/KRAS. Interaction with HRAS/KRAS is required for Ras-driven tumor formation. Mutations increasing the lipid kinase activity are required for oncogenic signaling. The protein kinase activity may not be required for tumorigenesis.MISCELLANEOUS The avian sarcoma virus 16 genome encodes an oncogene derived from PIK3CA.SIMILARITY Belongs to the PI3/PI4-kinase family. UniProt P42336 1 平等的 1068 平等的 反应数据库ID版本77 74787 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74787 反应 r - hsa - 74787 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-74787.1 PIK3CB pi3 -激酶p110催化亚基beta 磷脂酰肌醇3-激酶催化亚基，β亚型(EC 2.7.1.137) (pi3 -激酶p110亚基β) (ptdins -3-激酶p110) (PI3K) (PI3K) (PI3K) 磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基，β亚型 Reactome DB_ID: 74788 UNIPROT：P42338 PIK3CB PIK3CB PIK3C1 磷脂酰肌醇-3-激酶(PI3K)在肌醇环的3位磷酸化磷脂酰肌醇衍生物，产生3-磷酸肌醇(PubMed:15135396)。使用ATP和PtdIns(4,5)P2(磷脂酰肌醇4,5-二磷酸)生成磷脂酰肌醇3,4,5-三磷酸(PIP3) (PubMed:15135396)。PIP3通过将包含PH结构域的蛋白招募到细胞膜上，包括AKT1和PDPK1，激活涉及细胞生长、存活、增殖、运动和形态的信号级联，发挥着关键作用。参与g蛋白偶联受体(GPCRs)配体(如CXCL12、鞘氨醇1-磷酸和溶血磷脂酸)刺激后AKT1的激活。也可作用于下游受体酪氨酸激酶。稳定的血小板粘附和聚集所需的不同信号通路。在GPCRs、α - iib / β -3整合素(ITGA2B/ ITGB3)和ITAM(免疫受体酪氨酸激活基序)受体(如GP6)触发的血小板激活信号中发挥作用。调节收缩力细胞传递所必需的ITGA2B/ ITGB3活化受体的粘附强度。F2(凝血酶)和血栓素A2 (TXA2)诱导的血小板聚集所需。对细胞存活有一定作用 May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.PATHWAY Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.SUBUNIT Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity).TISSUE SPECIFICITY Expressed ubiquitously.DOMAIN The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival.PTM Phosphorylation at Ser-1070 down-regulates lipid kinase activity.SIMILARITY Belongs to the PI3/PI4-kinase family. UniProt P42338 1 平等的 1070 平等的 反应数据库ID版本77 74788 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74788 反应 r - hsa - 74788 1 Reactome稳定的标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-74788.1 反应数据库ID版本77 74689. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74689 反应 r - hsa - 74689 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-74689.1 1 从Reactome中的EntitySet转换而来 PI3K-regulatory亚基 Reactome DB_ID: 74688 PIK3R1 PI3K P85阿尔法 磷脂酰肌醇3-激酶调节α亚基 pi3-激酶p85-alpha亚基 PtdIns-3-kinase p85-alpha Reactome DB_ID: 74789 UniProt: P27986 PIK3R1 PIK3R1 GRB1 功能与活化（磷酸化）蛋白-TYR激酶，通过其SH2结构域结合，并用作介于衔接子，介导P110催化单元与质膜的关联。胰岛素敏感组织中葡萄糖摄取和糖原合成的胰岛素刺激的增加所必需的。响应于FGFR1，FGFR2，FGFR3，FGFR4，KITLG / SCF，试剂盒，PDGFRA和PDGFRB，在信号传导中发挥重要作用。同样，在ITGB2信令中起作用（PubMed：17626883，PubMed：19805105，PubMed：7518429）。通过在肝脏代谢过载期间促进XBP1同种型2的XbP1同种型2的核转位来调节对ER应力的细胞响应，并且因此在葡萄糖耐量改善中发挥作用（PubMed：20348923）.subunit异二聚体监管亚基PIK3R1和P110催化亚基（PIK3CA，PIK3CB或PIK3CD）。用CCDC88A / giV（酪氨酸磷酸化形式）相互作用（通过SH2结构域）;相互作用使得能够募集PIK3R1至EGFR受体，增强PI3K活性和细胞迁移（PubMed：21954290）。用CSF1R（酪氨酸磷酸化）相互作用（通过SH2结构域）。与pik3r2互动; the interaction is dissociated in an insulin-dependent manner (By similarity). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (PubMed:20348923). Interacts with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon ligand-binding). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (PubMed:23676467). Interacts with APPL1 and APPL2 (By similarity). Interacts with SRC (PubMed:28903391). Interacts with ALOX5; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (PubMed:21200133).SUBUNIT (Microbial infection) Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV.SUBUNIT (Microbial infection) Interacts with HCV NS5A.SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 UL46; this interaction activates the PI3K/AKT pathway.SUBUNIT (Microbial infection) Interacts with herpes simplex virus 1 UL46 and varicella virus ORF12; this interaction activates the PI3K/AKT pathway.TISSUE SPECIFICITY Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).DOMAIN The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.PTM Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.PTM Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.SIMILARITY Belongs to the PI3K p85 subunit family. UniProt P27986 1 平等的 724. 平等的 反应数据库ID版本77 74789 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74789 反应 r - hsa - 74789 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-74789.1 PIK3R2 PI3K-p85β 磷脂酰肌醇3-激酶调节亚基 pi3激酶p85-beta亚基 PtdIns-3-kinase p85-beta Reactome DB_ID: 74791 UNIPROT：O00459 PIK3R2 PIK3R2 磷酸肌醇3-激酶（PI3K）的FUNCTION调节亚基，一个激酶磷酸化磷脂酰肌醇（4,5）P2（磷脂酰肌醇4,5-二磷酸），以产生磷脂酰肌醇3,4,5-三磷酸（PIP3）。PIP3通过将包含PH结构域的蛋白招募到细胞膜上，包括AKT1和PDPK1，激活涉及细胞生长、存活、增殖、运动和形态的信号级联，发挥着关键作用。结合活化（磷酸化）的蛋白质 - 酪氨酸激酶，通过其SH2结构域，并作为一个适配器，介导P110催化单元的关联至质膜。间接调节自噬（PUBMED：23604317）。在肝脏代谢超载期间促进在ER应力和/或胰岛素依赖性XBP1亚型2的核转，因此在葡萄糖耐受性的改善作用（通过相似性）调节亚基PIK3R2和P110催化的.SUBUNIT异源二聚体亚基（PIK3CA，PIK3CB或PIK3CD）（搜索PubMed：23604317）。与AXL相互作用（PUBMED：9178760）。与FLT1（酪氨酸磷酸化）和FLT4（酪氨酸磷酸化）相互作用（搜索PubMed：9600074，PUBMED：15102829）。化与NYAP1，NYAP2和MYO16（通过相似性）。与FBXL2相互作用; PIK3R2 is a substrate of the SCF(FBXL2) complex (PubMed:23604317). Interacts with PTPN13; dephosphorylates PIK3R2 (PubMed:23604317). Interacts with XBP1 isoform 2; the interaction is direct and induces translocation of XBP1 isoform 2 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner (By similarity). Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner (By similarity). Interacts with SRC (PubMed:28903391).DOMAIN The SH2 2 domain is required for interaction with FBXL2 and PTPN13.PTM Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).PTM Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.SIMILARITY Belongs to the PI3K p85 subunit family. UniProt O00459 1 平等的 728. 平等的 反应数据库ID版本77 74791 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74791 反应 r - hsa - 74791 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-74791.1 反应数据库ID版本77 74688 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74688 反应 r - hsa - 74688 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-74688.1 1 反应数据库ID版本77 74693 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74693 反应 r - hsa - 74693 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-74693.1 ComplexPortal CPX-73. PDGF: Phospho-PDGF受体二聚体:PI3K Reactome DB_ID: 186789 1 1 反应数据库ID版本77 186789. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186789 反应 R-HSA-186789 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186789.2 反应数据库ID版本77 186780 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186780 反应 R-HSA-186780 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-186780.1 1374684 PubMed. 1992 生长因子受体上的不同磷酸酪氨酸与介导不同信号通路的特定分子结合 Fantl, WJ Escobedo, JA 马丁，GA Turck,连续波 罗萨里奥,M 麦考密克F 威廉姆斯,LT 小区69：413-23 2466336. PubMed. 1989 磷脂酰肌醇激酶在PDGF受体信号转导中的作用 Coughlin,老 Escobedo, JA 威廉姆斯,LT 科学243:1191-4 9739761. PubMed. 1998 通过血小板来源的生长因子受体的信号转导 Holdin，Carl-Henrik Ostman, Rönnstrand，Lars. 生物物理学报1378:F79-113