The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome ATP,GTP,CTP,ITP,UTP Reactome DB_ID: 8936166 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 114570 extracellular region GENE ONTOLOGY GO:0005576 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 114570 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=114570 Reactome R-ALL-114570 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114570.3 Reactome //www.joaskin.com COMPOUND C00002 additional information MI MI:0361 GTP Guanosine 5'-triphosphate Reactome DB_ID: 114626 GTP [ChEBI:15996] GTP Guanosine 5'-triphosphate ChEBI CHEBI:15996 Reactome Database ID Release 77 114626 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=114626 Reactome R-ALL-114626 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114626.2 COMPOUND C00044 UTP uridine 5'-triphosphate Uridine triphosphate Reactome DB_ID: 417877 UTP [ChEBI:15713] UTP uridine 5'-triphosphate Uridine triphosphate ChEBI CHEBI:15713 Reactome Database ID Release 77 417877 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=417877 Reactome R-ALL-417877 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-417877.2 COMPOUND C00075 CTP Cytidine 5'-triphosphate Cytidine triphosphate Reactome DB_ID: 8851086 CTP [ChEBI:17677] CTP cytidine 5'-triphosphate Cytidine triphosphate ChEBI CHEBI:17677 Reactome Database ID Release 77 8851086 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8851086 Reactome R-ALL-8851086 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851086.3 ITP Inosine 5'-triphosphate Inosine triphosphate Reactome DB_ID: 8851093 ITP [ChEBI:16039] ITP Inosine 5'-triphosphate Inosine triphosphate Inosine tripolyphosphate ChEBI CHEBI:16039 Reactome Database ID Release 77 8851093 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8851093 Reactome R-ALL-8851093 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851093.3 Reactome Database ID Release 77 8936166 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8936166 Reactome R-ALL-8936166 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8936166.1 H2O water Reactome DB_ID: 109276 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 77 109276 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=109276 Reactome R-ALL-109276 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109276.4 COMPOUND C00001 Pi Orthophosphate hydrogenphosphate inorganic phosphate phosphate Reactome DB_ID: 109277 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate [PO3(OH)](2-) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE离子 HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 77 109277 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=109277 Reactome R-ALL-109277 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109277.4 COMPOUND C00009 Converted from EntitySet in Reactome ADP,GDP,CDP,IDP,UDP Reactome DB_ID: 8851092 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 114564 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 114564 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=114564 Reactome R-ALL-114564 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114564.4 COMPOUND C00008 GDP Guanosine 5'-diphosphate Guanosine diphosphate Reactome DB_ID: 114623 GDP [ChEBI:17552] GDP Guanosine 5'-diphosphate Guanosine diphosphate ChEBI CHEBI:17552 Reactome Database ID Release 77 114623 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=114623 Reactome R-ALL-114623 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114623.2 COMPOUND C00035 CDP Cytidine 5'-diphosphate Cytidine diphosphate Reactome DB_ID: 8851368 CDP [ChEBI:17239] CDP Cytidine 5'-diphosphate Cytidine diphosphate ChEBI CHEBI:17239 Reactome Database ID Release 77 8851368 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8851368 Reactome R-ALL-8851368 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851368.3 IDP Inosine 5'-diphosphate Inosine diphosphate Reactome DB_ID: 8851463 IDP [ChEBI:17808] IDP Inosine 5'-diphosphate Inosine diphosphate ChEBI CHEBI:17808 Reactome Database ID Release 77 8851463 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8851463 Reactome R-ALL-8851463 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851463.3 UDP uridine 5'-diphosphate Reactome DB_ID: 417888 UDP [ChEBI:17659] UDP ChEBI CHEBI: 17659 Reactome Database ID Release 77 417888 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=417888 Reactome R-ALL-417888 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-417888.2 COMPOUND C00015 Reactome Database ID Release 77 8851092 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8851092 Reactome R-ALL-8851092 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8851092.2 ACTIVATION NTPDase2:Ca2+,Mg2+ Reactome DB_ID: 10778679 plasma membrane GENE ONTOLOGY GO:0005886 Converted from EntitySet in Reactome Ca2+,Mg2+ Reactome DB_ID: 8850849 Ca2+ Calcium calcium(2+) Reactome DB_ID: 74112 calcium(2+) [ChEBI:29108] calcium(2+) ChEBI CHEBI:29108 Reactome Database ID Release 77 74112 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74112 Reactome R-ALL-74112 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-74112.4 COMPOUND C00076 Mg2+ Magnesium magnesium(2+) Mg++ Reactome DB_ID: 114632 magnesium(2+) [ChEBI:18420] magnesium(2+) ChEBI CHEBI:18420 Reactome Database ID Release 77 114632 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=114632 Reactome R-ALL-114632 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-114632.4 COMPOUND C00305 Reactome Database ID Release 77 8850849 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8850849 Reactome R-ALL-8850849 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8850849.2 1 Converted from EntitySet in Reactome Homologues of ENTPD2 Reactome DB_ID: 10778677 ENTPD2 Q8IE96 Reactome DB_ID: 10778673 UniProt:Q8IE96 Plasmodium falciparum NCBI Taxonomy 5833 UniProt Q8IE96 1 EQUAL 495 EQUAL Reactome Database ID Release 77 10778673 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778673 Reactome R-PFA-8851088 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-8851088.1 ENTPD2 Q8ILE7 Reactome DB_ID: 10778675 UniProt:Q8ILE7 UniProt Q8ILE7 1 EQUAL 495 EQUAL Reactome Database ID Release 77 10778675 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778675 Reactome R-PFA-8851088-2 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-8851088-2.1 Reactome Database ID Release 77 10778677 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778677 Reactome R-PFA-8851088-3 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-8851088-3.1 1 Reactome Database ID Release 77 10778679 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778679 Reactome R-PFA-8851095 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-8851095.1 GENE ONTOLOGY GO:0017111 gene ontology term for cellular function MI MI:0355 相同的催化剂Activity Reactome Database ID Release 77 10778680 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778680 Reactome Database ID Release 77 10778682 数据库标识符。Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10778682 Reactome R-PFA-8851089 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-8851089.1 NTPDase2 (CD39L1), encoded by the ENTPD2 gene, is an ectonucleoside triphosphate diphosphohydrolase that is expressed at the plasma membrane where it hydrolyzes extracellular nucleoside triphosphates (ATP, GTP, CTP, ITP, UTP) to the respective nucleoside diphosphate (ADP, GDP, CDP, IDP, UDP) in the presence of Ca2+ of Mg2+ ions. NTPDase2 is only marginally active in hydrolyzing nucleoside diphosphates, such as ADP and UDP (Kegel et al. 1997, Kirley et al. 1997, Mateo et al. 1999). The alpha splicing isoform of NTPDase2 is expressed at the plasma membrane, while beta and gamma isoforms are expressed in the endoplasmic reticulum (Mateo et al. 2003). NTPDase2 may oligomerize and the oligomerization state may affect substrate specificity (Failer et al. 2003).

NTPDase2 may contribute to vascular hemostasis by exerting an opposing role to NTPDase1 (Sévigny et al. 2002). 11929769 Pubmed 2002 Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation Sévigny, Jean Sundberg, Christian Braun, Norbert Guckelberger, Olaf Csizmadia, Eva Qawi, Imrana Imai, Masato Zimmermann, H Robson, Simon C Blood 99:2801-9 12888562 Pubmed 2003 Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme Mateo, Jesús Kreda, Silvia Henry, Christopher E Harden, T Kendall Boyer, José L J. Biol. Chem. 278:39960-8 10510450 Pubmed 1999 Functional expression of a cDNA encoding a human ecto-ATPase Mateo, J Harden, T K Boyer, J L Br. J. Pharmacol. 128:396-402 12694193 Pubmed 2003 确定原生低聚物的状态和路径替换rate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes Failer, Bernd U Aschrafi, Armaz Schmalzing, Günther Zimmermann, H Eur. J. Biochem. 270:1802-9 8995405 Pubmed 1997 Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase. Homology with the lymphoid cell activation antigen CD39 Kirley, T L J. Biol. Chem. 272:1076-81 9364474 Pubmed 1997 An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain Kegel, B Braun, N Heine, P Maliszewski, C R Zimmermann, H Neuropharmacology 36:1189-200 inferred from electronic annotation EVIDENCE CODE ECO:0000203