The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT 2.4.2.7 Adenine + PRPP => AMP + PPi 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PRPP 5-phospho-alpha-D-ribose 1-diphosphate 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-Phosphoribosyl diphosphate 5-Phosphoribosyl 1-pyrophosphate Reactome DB_ID: 73566 cytosol GENE ONTOLOGY GO:0005829 5-O-phosphono-alpha-D-ribofuranosyl diphosphate [ChEBI:17111] 5-O-phosphono-alpha-D-ribofuranosyl diphosphate ChEBI CHEBI:17111 Reactome Database ID Release 77 73566 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=73566 Reactome R-ALL-73566 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-73566.3 Reactome //www.joaskin.com COMPOUND C00119 additional information MI MI:0361 Ade 6-aminopurine adenine Reactome DB_ID: 83951 adenine [ChEBI:16708] adenine 6-aminopurine ChEBI CHEBI:16708 Reactome Database ID Release 77 83951 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83951 Reactome R-ALL-83951 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83951.3 COMPOUND C00147 PPi pyrophosphate diphosphoric acid pyrophosphoric acid diphosphate Reactome DB_ID: 111294 diphosphoric acid [ChEBI:29888] diphosphoric acid ChEBI CHEBI:29888 Reactome Database ID Release 77 111294 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=111294 Reactome R-ALL-111294 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-111294.3 COMPOUND C00013 AMP adenosine 5'-monophosphate Adenylic acid Adenylate 5'-AMP 5'-Adenylic acid 5'-Adenosine monophosphate Adenosine 5'-phosphate Reactome DB_ID: 76577 adenosine 5'-monophosphate [ChEBI:16027] adenosine 5'-monophosphate ChEBI CHEBI:16027 Reactome Database ID Release 77 76577 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=76577 Reactome R-ALL-76577 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-76577.4 COMPOUND C00020 ACTIVATION APRT dimer Reactome DB_ID: 10576909 APRT P91455 Reactome DB_ID: 10576907 UniProt:P91455 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt P91455 2 EQUAL 180 EQUAL Reactome Database ID Release 77 10576907 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576907 Reactome R-CEL-50171 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-50171.1 2 Reactome Database ID Release 77 10576909 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576909 Reactome R-CEL-74211 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74211.1 GENE ONTOLOGY GO:0003999 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 10576910 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576910 Reactome Database ID Release 77 10576912 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576912 Reactome R-CEL-74213 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74213.1 阶段solic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979). 457664 Pubmed 1979 Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping. Holden, JA Meredith, GS Kelley, WN J Biol Chem 254:6951-5 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 3.5.4.6 AMP + H2O => IMP + NH4+ (AMPD) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI: 15377 Reactome Database ID Release 77 29356 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 IMP Inosinic acid Inosine monophosphate Inosine 5'-monophosphate Inosine 5'-phosphate 5'-Inosinate 5'-Inosinic acid 5'-Inosine monophosphate Reactome DB_ID: 29602 IMP [ChEBI:17202] IMP Inosinic acid Inosine monophosphate Inosine 5'-monophosphate Inosine 5'-phosphate 5'-Inosinate 5'-Inosinic acid 5'-Inosine monophosphate ChEBI CHEBI:17202 Reactome Database ID Release 77 29602 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29602 Reactome R-ALL-29602 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29602.2 COMPOUND C00130 NH4+ ammonium Reactome DB_ID: 31633 ammonium [ChEBI:28938] ammonium ChEBI CHEBI:28938 Reactome Database ID Release 77 31633 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=31633 Reactome R-ALL-31633 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-31633.3 COMPOUND C01342 ACTIVATION Converted from EntitySet in Reactome AMPD tetramers Reactome DB_ID: 10578607 AMPD1 tetramer Reactome DB_ID: 10578597 AMPD1 ampd-1 A0A2C9C377 Reactome DB_ID: 10578595 UniProt:A0A2C9C377 ampd-1 UniProt A0A2C9C377 1 EQUAL 780 EQUAL Reactome Database ID Release 77 10578595 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578595 Reactome R-CEL-49925 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-49925.1 4 Reactome Database ID Release 77 10578597 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578597 Reactome R-CEL-76595 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-76595.1 AMPD2 tetramer Reactome DB_ID: 10578601 AMPD2 ampd-1 A0A2C9C377 Reactome DB_ID: 10578599 1 EQUAL 879 EQUAL Reactome Database ID Release 77 10578599 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578599 Reactome R-CEL-49927 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-49927.1 4 Reactome Database ID Release 77 10578601 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578601 Reactome R-CEL-76586 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-76586.1 AMPD3 tetramer Reactome DB_ID: 10578605 AMPD3 ampd-1 A0A2C9C377 Reactome DB_ID: 10578603 1 EQUAL 767 EQUAL Reactome Database ID Release 77 10578603 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578603 Reactome R-CEL-49929 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-49929.1 4 Reactome Database ID Release 77 10578605 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578605 Reactome R-CEL-76601 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-76601.1 Reactome Database ID Release 77 10578607 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578607 Reactome R-CEL-500235 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-500235.1 GENE ONTOLOGY GO:0003876 Reactome Database ID Release 77 10578608 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578608 Reactome Database ID Release 77 10578610 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578610 Reactome R-CEL-76590 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-76590.1 阶段solic AMP deaminase (AMPD) catalyzes the hydrolysis of AMP to yield IMP and ammonia. Three isoforms of AMPD, E, L, and M, have been identified that differ in their expression patterns in the body. All occur as tetramers and all have qualitatively the same catalytic activity, however (Bausch-Jurken et al. 1992; Mahnke-Zizelman et al. 1998). 1429593 Pubmed 1992 Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA Bausch-Jurken, MT Mahnke-Zizelman, DK Morisaki, T Sabina, RL J Biol Chem 267:22407-13 9857047 Pubmed 1998 Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms Mahnke-Zizelman, DK Tullson, PC Sabina, RL J Biol Chem 273:35118-25 LEFT-TO-RIGHT 2.4.2.8 guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome Gua, Hyp guanine, hypoxanthine Reactome DB_ID: 500259 Gua 2-amino-6-hydroxypurine guanine Reactome DB_ID: 83956 guanine [ChEBI:16235] guanine 2-amino-6-hydroxypurine ChEBI CHEBI:16235 Reactome Database ID Release 77 83956 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83956 Reactome R-ALL-83956 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83956.3 COMPOUND C00242 忧郁 hypoxanthine Purine-6-ol Reactome DB_ID: 113599 hypoxanthine [ChEBI:17368] hypoxanthine ChEBI CHEBI:17368 Reactome Database ID Release 77 113599 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113599 Reactome R-ALL-113599 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113599.4 COMPOUND C00262 Reactome Database ID Release 77 500259 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500259 Reactome R-ALL-500259 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500259.2 Converted from EntitySet in Reactome GMP, IMP Reactome DB_ID: 500260 GMP guanosine 5'-monophosphate Guanosine 5'-phosphate Guanosine monophosphate 鸟苷酸 Reactome DB_ID: 113578 guanosine 5'-monophosphate [ChEBI:17345] guanosine 5'-monophosphate ChEBI CHEBI:17345 Reactome Database ID Release 77 113578 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113578 Reactome R-ALL-113578 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113578.4 COMPOUND C00144 Reactome Database ID Release 77 500260 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500260 Reactome R-ALL-500260 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500260.1 ACTIVATION HGPRT tetramer Reactome DB_ID: 10576919 HPRT1 hprt-1 Q9NF11 Reactome DB_ID: 10576917 UniProt:Q9NF11 hprt-1 UniProt Q9NF11 2 EQUAL 218 EQUAL Reactome Database ID Release 77 10576917 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576917 Reactome R-CEL-56639 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-56639.1 4 Mg2+ Magnesium magnesium(2+) Mg++ Reactome DB_ID: 29926 magnesium(2+) [ChEBI:18420] magnesium(2+) ChEBI CHEBI:18420 Reactome Database ID Release 77 29926 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29926 Reactome R-ALL-29926 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29926.5 COMPOUND C00305 8 Reactome Database ID Release 77 10576919 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576919 Reactome R-CEL-74208 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74208.1 GENE ONTOLOGY GO:0004422 Reactome Database ID Release 77 10576920 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576920 Reactome Database ID Release 77 10576922 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576922 Reactome R-CEL-74215 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74215.1 阶段solic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983). 6300847 Pubmed 1983 Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase Jolly, DJ Okayama, H Berg, P Esty, AC Filpula, D Bohlen, P Johnson, GG Shively, JE Hunkapillar, T Friedmann, T Proc Natl Acad Sci U S A 80:477-81 LEFT-TO-RIGHT 3.5.4.4 N6-methyl-AMP + H2O => IMP + methylamine Deamination of N6-methyl-AMP to form IMP 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp N6-methyl-AMP N(6)-methyl-AMP Reactome DB_ID: 2161190 N(6)-methyl-AMP [ChEBI:40196] N(6)-methyl-AMP ChEBI CHEBI:40196 Reactome Database ID Release 77 2161190 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2161190 Reactome R-ALL-2161190 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2161190.3 methylamine Reactome DB_ID: 2161177 methylamine [ChEBI:16830] methylamine ChEBI CHEBI:16830 Reactome Database ID Release 77 2161177 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2161177 Reactome R-ALL-2161177 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2161177.2 ACTIVATION ADAL:Zn Reactome DB_ID: 10610445 ADAL adal-1 Q8IG39 Reactome DB_ID: 10610443 UniProt:Q8IG39 adal-1 UniProt Q8IG39 1 EQUAL 355 EQUAL Reactome Database ID Release 77 10610443 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10610443 Reactome R-CEL-2161180 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2161180.1 1 Zn2+ Zn++ zinc(2+) Zinc ion Zn(II) Reactome DB_ID: 29426 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI CHEBI:29105 Reactome Database ID Release 77 29426 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29426 Reactome R-ALL-29426 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29426.3 COMPOUND C00038 1 Reactome Database ID Release 77 10610445 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10610445 Reactome R-CEL-2161178 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2161178.1 GENE ONTOLOGY GO:0004000 Reactome Database ID Release 77 10610446 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10610446 Reactome Database ID Release 77 10610448 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10610448 Reactome R-CEL-2161187 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2161187.1 阶段solic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-AMP and water to form IMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). 21755941 Pubmed 2011 Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates Murakami, E Bao, H Mosley, RT Du, J Sofia, MJ Furman, PA J Med Chem 54:5902-14 LEFT-TO-RIGHT 2.7.1.20 (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome Ade-Rib, dA adenosine, deoxyadenosine Reactome DB_ID: 500173 Ade-Rib ADENOCARD (TN) adenosine Reactome DB_ID: 83909 adenosine [ChEBI:16335] adenosine ChEBI CHEBI:16335 Reactome Database ID Release 77 83909 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83909 Reactome R-ALL-83909 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83909.3 COMPOUND C00212 dA deoxyadenosine 2'-deoxyadenosine Reactome DB_ID: 83925 2'-deoxyadenosine [ChEBI:17256] 2'-deoxyadenosine deoxyadenosine ChEBI CHEBI:17256 Reactome Database ID Release 77 83925 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83925 Reactome R-ALL-83925 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83925.3 COMPOUND C00559 Reactome Database ID Release 77 500173 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500173 Reactome R-ALL-500173 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500173.2 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 113592 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 Converted from EntitySet in Reactome (d)AMP Reactome DB_ID: 500088 dAMP 2'-deoxyadenosine 5'-monophosphate deoxyadenylic acid 2'-Deoxyadenosine 5'-phosphate Deoxyadenosine monophosphate Reactome DB_ID: 109386 2'-deoxyadenosine 5'-monophosphate [ChEBI:17713] 2'-deoxyadenosine 5'-monophosphate ChEBI CHEBI:17713 Reactome Database ID Release 77 109386 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=109386 Reactome R-ALL-109386 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109386.3 COMPOUND C00360 Reactome Database ID Release 77 500088 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500088 Reactome R-ALL-500088 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500088.1 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 ACTIVATION ADK Reactome DB_ID: 10578928 1 ADK adk-1 Q93934 Reactome DB_ID: 10578926 UniProt:Q93934 adk-1 UniProt Q93934 1 EQUAL 362 EQUAL Reactome Database ID Release 77 10578926 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578926 Reactome R-CEL-49725 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-49725.1 1 Reactome Database ID Release 77 10578928 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578928 Reactome R-CEL-76542 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-76542.1 GENE ONTOLOGY GO:0004001 Reactome Database ID Release 77 10578929 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578929 Reactome Database ID Release 77 10578931 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10578931 Reactome R-CEL-109624 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-109624.1 阶段solic adenosine kinase (ADK) catalyzes the reactions of adenosine and deoxyadenosine with ATP to yield the corresponding nucleotide monophosphates and ADP (Andres and Fox 1979). The enzyme is substantially more active on adenosine than deoxyadenosine in vitro (Hurley at al. 1985) though studies of cultured cells suggest that both reactions may be physiologically relevant (Hershfield et al. 1982). The enzyme is a monomer complexed with magnesium (Mathews et al. 1998). 2999129 Pubmed 1985 Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase Hurley, MC Lin, B Fox, IH J Biol Chem 260:15675-15681 227870 Pubmed 1979 Purification and properties of human placental adenosine kinase Andres, CM Fox, IH J Biol Chem 254:11388-11393 6281270 Pubmed 1982 Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells Hershfield, MS Fetter, JE Small, WC Bagnara, AS Williams, SR Ullman, B Martin, Jr, DW Wasson, DB Carson, DA J Biol Chem 257:6380-6386 9843365 Pubmed 1998 Structure of human adenosine kinase at 1.5 A resolution. Mathews, II Erion, MD Ealick, SE Biochemistry 37:15607-20 LEFT-TO-RIGHT 3.5.4.4 (2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome Ino, dI inosine, deoxyinosine Reactome DB_ID: 500172 Ino inosine Reactome DB_ID: 83927 inosine [ChEBI:17596] inosine ChEBI CHEBI:17596 Reactome Database ID Release 77 83927 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83927 Reactome R-ALL-83927 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83927.3 COMPOUND C00294 dI deoxyinosine 2'-deoxyinosine Reactome DB_ID: 109331 2'-deoxyinosine [ChEBI:28997] 2'-deoxyinosine deoxyinosine ChEBI CHEBI:28997 Reactome Database ID Release 77 109331 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=109331 Reactome R-ALL-109331 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109331.3 COMPOUND C05512 Reactome Database ID Release 77 500172 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500172 Reactome R-ALL-500172 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500172.2 ACTIVATION ADA adah-1 H2KYI5 Reactome DB_ID: 10576932 UniProt:H2KYI5 adah-1 UniProt H2KYI5 2 EQUAL 363 EQUAL Reactome Database ID Release 77 10576932 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576932 Reactome R-CEL-49701 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-49701.1 Reactome Database ID Release 77 10576933 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576933 Reactome Database ID Release 77 10576935 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576935 Reactome R-CEL-74241 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74241.1 阶段solic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer. 3182793 Pubmed 1988 Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts Akeson, AL Wiginton, DA Dusing, MR States, JC Hutton, JJ J Biol Chem 263:16291-6 LEFT-TO-RIGHT 2.4.2.1 guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome R1P, dRibP ribose 1-phosphate, deoxyribose 1-phosphate Reactome DB_ID: 500244 R1P D-ribose 1-phosphate Reactome DB_ID: 112016 D-ribose 1-phosphate [ChEBI:35425] D-ribose 1-phosphate ChEBI CHEBI:35425 Reactome Database ID Release 77 112016 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=112016 Reactome R-ALL-112016 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-112016.3 COMPOUND C00620 dRibP 2-deoxy-D-ribose 1-phosphate 2-deoxy-D-ribofuranose 1-phosphate Reactome DB_ID: 112032 2-deoxy-D-ribofuranose 1-phosphate [ChEBI:28542] 2-deoxy-D-ribofuranose 1-phosphate ChEBI CHEBI:28542 Reactome Database ID Release 77 112032 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=112032 Reactome R-ALL-112032 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-112032.3 COMPOUND C00672 Reactome Database ID Release 77 500244 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500244 Reactome R-ALL-500244 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500244.2 Converted from EntitySet in Reactome G, dG guanosine, deoxyguanosine Reactome DB_ID: 500245 Gua-Rib guanosine Reactome DB_ID: 83926 guanosine [ChEBI:16750] guanosine ChEBI CHEBI:16750 Reactome Database ID Release 77 83926 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=83926 Reactome R-ALL-83926 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-83926.3 COMPOUND C00387 dG deoxyguanosine 2'-deoxyguanosine Reactome DB_ID: 109328 2'-deoxyguanosine [ChEBI:17172] 2'-deoxyguanosine ChEBI CHEBI:17172 Reactome Database ID Release 77 109328 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=109328 Reactome R-ALL-109328 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109328.3 COMPOUND C00330 Reactome Database ID Release 77 500245 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=500245 Reactome R-ALL-500245 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-500245.1 Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 29372 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate (警察丙(OH)) (2) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE ION HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 77 29372 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29372 Reactome R-ALL-29372 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29372.4 COMPOUND C00009 ACTIVATION NP trimer Reactome DB_ID: 10576942 PNP pnp-1 U4PSA1 Reactome DB_ID: 10576940 UniProt:U4PSA1 pnp-1 UniProt U4PSA1 1 EQUAL 289 EQUAL Reactome Database ID Release 77 10576940 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576940 Reactome R-CEL-61933 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-61933.1 3 Reactome Database ID Release 77 10576942 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576942 Reactome R-CEL-74237 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74237.1 GENE ONTOLOGY GO:0004731 Reactome Database ID Release 77 10576943 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10576943 Reactome Database ID Release 77 10579734 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10579734 Reactome R-CEL-112034 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-112034.1 阶段solic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of guanine with ribose 1-phosphate or deoxyribose 1-phosphate to form guanosine or deoxyguanosine and orthophosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either ribose 1-phosphate or deoxyribose 1-phosphate in vitro, levels of deoxyribose 1-phosphate are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987). 3029074 Pubmed 1987 A human purine nucleoside phosphorylase deficiency caused by a single base change Williams, SR Gekeler, V McIvor, RS Martin, Jr, DW J Biol Chem 262:2332-2338 2104852 Pubmed 1990 Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution Ealick, SE Rule, SA Carter, DC Greenhough, TJ Babu, YS Cook, WJ Habash, J Helliwell, JR Stoeckler, JD Parks, Jr, RE Chen, SF Bugg, CE J Biol Chem 265:1812-1820 6771276 Pubmed 1980 Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides Wiginton, DA Coleman, MS Hutton, JJ J Biol Chem 255:6663-6669 LEFT-TO-RIGHT 2.4.2.1 hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ACTIVATION Reactome Database ID Release 77 10579732 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10579732 Reactome R-CEL-112033 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-112033.1 阶段solic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of hypoxanthine with ribose 1-phosphate or deoxyribose 1-phosphate to form inosine or deoxyinosine and orthophosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either ribose 1-phosphate or deoxyribose 1-phosphate in vitro, levels of deoxyribose 1-phosphate are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987). LEFT-TO-RIGHT 1.7.1.7 GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) 这个事件已经计算推断an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp TPNH NADPH Reactome DB_ID: 29364 NADPH [ChEBI:16474] NADPH TPNH ChEBI CHEBI:16474 Reactome Database ID Release 77 29364 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29364 Reactome R-ALL-29364 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29364.2 COMPOUND C00005 H+ proton hydron Reactome DB_ID: 70106 hydron [ChEBI:15378] hydron ChEBI CHEBI: 15378 Reactome Database ID Release 77 70106 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=70106 Reactome R-ALL-70106 4 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4 COMPOUND C00080 TPN NADP+ NADP NADP(+) Nicotinamide adenine dinucleotide phosphate beta-Nicotinamide adenine dinucleotide phosphate Triphosphopyridine nucleotide Reactome DB_ID: 29366 NADP(+) [ChEBI:18009] NADP(+) ChEBI CHEBI:18009 Reactome Database ID Release 77 29366 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29366 Reactome R-ALL-29366 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29366.3 COMPOUND C00006 ACTIVATION Converted from EntitySet in Reactome GMPR四聚物s Reactome DB_ID: 10598224 GMPR四聚物 Reactome DB_ID: 10598218 GMPR O16294 Reactome DB_ID: 10598216 UniProt:O16294 UniProt O16294 1 EQUAL 345 EQUAL Reactome Database ID Release 77 10598216 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598216 Reactome R-CEL-514605 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514605.1 4 Reactome Database ID Release 77 10598218 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598218 Reactome R-CEL-514628 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514628.1 GMPR2 tetramer Reactome DB_ID: 10598222 GMPR2 O16294 Reactome DB_ID: 10598220 1 EQUAL 348 EQUAL Reactome Database ID Release 77 10598220 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598220 Reactome R-CEL-514631 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514631.1 4 Reactome Database ID Release 77 10598222 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598222 Reactome R-CEL-514630 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514630.1 Reactome Database ID Release 77 10598224 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598224 Reactome R-CEL-514620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514620.1 GENE ONTOLOGY GO:0003920 Reactome Database ID Release 77 10598225 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598225 Reactome Database ID Release 77 10598227 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10598227 Reactome R-CEL-514604 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-514604.1 阶段solic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006). 12009299 Pubmed 2002 NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties Deng, Y Wang, Z Ying, K Gu, S Ji, C Huang, Y Gu, X Wang, Y Xu, Y Li, Y Xie, Y Mao, Y Int J Biochem Cell Biol 34:1035-50 218932 Pubmed 1979 Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators Spector, T Jones, TE Miller, RL J Biol Chem 254:2308-15 16359702 Pubmed 2006 Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP Li, J Wei, Z Zheng, M Gu, X Deng, Y Qiu, R Chen, F Ji, C Gong, W Xie, Y Mao, Y J Mol Biol 355:980-8 Reactome Database ID Release 77 10640994 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10640994 Reactome R-CEL-74217 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-74217.1 GENE ONTOLOGY GO:0043101 gene ontology term for cellular process MI MI:0359 Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis and interconversiohn. Under normal conditions, DNA turnover is limited and deoxyribonucleotide salvage operates at a correspondingly low level (Watts 1974). 4620886 Pubmed 1974 Molecular variation in relation to purine metabolism Watts, RW J Clin Pathol Suppl (R Coll Pathol) 8:48-63