The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Converted from EntitySet in Reactome NTP Reactome DB_ID: 30595 ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 nucleoplasm GENE ONTOLOGY GO:0005654 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 29358 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 Reactome //www.joaskin.com COMPOUND C00002 additional information MI MI:0361 CTP cytidine 5'-triphosphate Cytidine triphosphate Reactome DB_ID: 29470 CTP [ChEBI:17677] CTP cytidine 5'-triphosphate Cytidine triphosphate ChEBI CHEBI:17677 Reactome Database ID Release 77 29470 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29470 Reactome R-ALL-29470 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29470.2 COMPOUND C00063 GTP Guanosine 5'-triphosphate Reactome DB_ID: 113571 GTP [ChEBI:15996] GTP Guanosine 5'-triphosphate ChEBI CHEBI:15996 Reactome Database ID Release 77 113571 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113571 Reactome R-ALL-113571 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113571.2 COMPOUND C00044 UTP uridine 5'-triphosphate Uridine triphosphate Reactome DB_ID: 113562 UTP [ChEBI:15713] UTP uridine 5'-triphosphate Uridine triphosphate ChEBI CHEBI:15713 Reactome Database ID Release 77 113562 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113562 Reactome R-ALL-113562 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113562.2 COMPOUND C00075 Reactome Database ID Release 77 30595 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=30595 Reactome R-ALL-30595 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-30595.1 COMPOUND C00699 伸长复杂 Reactome DB_ID: 10503946 PAF1C Reactome DB_ID: 10503934 WDR61 Dmel\CG3909 Q9XZ19 Reactome DB_ID: 10503932 UniProt:Q9XZ19 Dmel\CG3909 Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q9XZ19 1 EQUAL 305 EQUAL Reactome Database ID Release 77 10503932 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503932 Reactome R-DME-8866696 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8866696.1 1 hyx CDC73 Q9VHI1 Reactome DB_ID: 10503907 UniProt:Q9VHI1 hyx UniProt Q9VHI1 2 EQUAL 531 EQUAL Reactome Database ID Release 77 10503907 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503907 Reactome R-DME-3322360 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3322360.1 1 Rtf1 RTF1 Q9W261 Reactome DB_ID: 10503927 UniProt:Q9W261 Rtf1 UniProt Q9W261 1 EQUAL 710 EQUAL Reactome Database ID Release 77 10503927 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503927 Reactome R-DME-8866693 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8866693.1 1 Ctr9 CTR9 Q7K0X3 Reactome DB_ID: 10503912 UniProt:Q7K0X3 Ctr9 UniProt Q7K0X3 1 EQUAL 1173 EQUAL Reactome Database ID Release 77 10503912 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503912 Reactome R-DME-8866694 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8866694.1 1 Atu LEO1 Q94546 Reactome DB_ID: 10503917 UniProt:Q94546 Atu UniProt Q94546 2 EQUAL 666 EQUAL Reactome Database ID Release 77 10503917 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503917 Reactome R-DME-3322361 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3322361.1 1 atms PAF1 Q9VN55 Reactome DB_ID: 10503922 UniProt:Q9VN55 atms UniProt Q9VN55 1 EQUAL 531 EQUAL Reactome Database ID Release 77 10503922 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503922 Reactome R-DME-8866689 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8866689.1 1 Reactome Database ID Release 77 10503934 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503934 Reactome R-DME-8866690 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8866690.1 1 Elongin Complex Reactome DB_ID: 10503902 Elongin B:C complex Reactome DB_ID: 10503891 EloC TCEB1 Q7JWD6 Reactome DB_ID: 10503884 UniProt:Q7JWD6 EloC UniProt Q7JWD6 1 EQUAL 112 EQUAL Reactome Database ID Release 77 10503884 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503884 Reactome R-DME-112422 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112422.1 1 EloB TCEB2 O44226 Reactome DB_ID: 10503889 UniProt:O44226 EloB UniProt O44226 1 EQUAL 118 EQUAL Reactome Database ID Release 77 10503889 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503889 Reactome R-DME-112423 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112423.1 1 Reactome Database ID Release 77 10503891 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503891 Reactome R-DME-112424 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112424.1 1 EloA TCEB3 Q9VCP0 Reactome DB_ID: 10503896 UniProt:Q9VCP0 EloA UniProt Q9VCP0 1 EQUAL 798 EQUAL Reactome Database ID Release 77 10503896 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503896 Reactome R-DME-112421 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112421.1 1 Reactome Database ID Release 77 10503902 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503902 Reactome R-DME-112425 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112425.1 1 TfIIS TCEA1 P20232 Reactome DB_ID: 10503867 UniProt:P20232 TfIIS UniProt P20232 1 EQUAL 301 EQUAL Reactome Database ID Release 77 10503867 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503867 Reactome R-DME-65748 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65748.1 1 TFIIH Reactome DB_ID: 10500661 hay ERCC3 Q02870 Reactome DB_ID: 10500634 UniProt:Q02870 hay UniProt Q02870 1 EQUAL 782 EQUAL Reactome Database ID Release 77 10500634 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500634 Reactome R-DME-67439 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67439.1 1 CAK Reactome DB_ID: 10500624 CycH CCNH O76513 Reactome DB_ID: 10500617 UniProt:O76513 CycH UniProt O76513 1 EQUAL 323 EQUAL Reactome Database ID Release 77 10500617 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500617 Reactome R-DME-69220 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69220.1 1 Mat1 MNAT1 Q7KPG8 Reactome DB_ID: 10500622 UniProt:Q7KPG8 Mat1 UniProt Q7KPG8 1 EQUAL 309 EQUAL Reactome Database ID Release 77 10500622 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500622 Reactome R-DME-59012 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-59012.1 1 Cdk7 CDK7 Q24216 Reactome DB_ID: 10500612 UniProt:Q24216 Cdk7 UniProt Q24216 1 EQUAL 346 EQUAL Reactome Database ID Release 77 10500612 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500612 Reactome R-DME-69218 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69218.1 1 Reactome Database ID Release 77 10500624 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500624 Reactome R-DME-69221 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-69221.1 1 Tfb1 GTF2H1 Q960E8 Reactome DB_ID: 10500654 UniProt:Q960E8 Tfb1 UniProt Q960E8 1 EQUAL 548 EQUAL Reactome Database ID Release 77 10500654 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500654 Reactome R-DME-65912 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65912.1 1 Ssl1 GTF2H2 Q9VNP8 Reactome DB_ID: 10500644 UniProt:Q9VNP8 Ssl1 UniProt Q9VNP8 1 EQUAL 395 EQUAL Reactome Database ID Release 77 10500644 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500644 Reactome R-DME-65914 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65914.1 1 Tfb4 GTF2H3 Q9VPX4 Reactome DB_ID: 10500639 UniProt:Q9VPX4 Tfb4 UniProt Q9VPX4 1 EQUAL 308 EQUAL Reactome Database ID Release 77 10500639 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500639 Reactome R-DME-65916 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65916.1 1 Tfb5 GTF2H5 B7Z018 Reactome DB_ID: 10500659 UniProt:B7Z018 Tfb5 UniProt B7Z018 1 EQUAL 71 EQUAL Reactome Database ID Release 77 10500659 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500659 Reactome R-DME-5688446 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5688446.1 1 mrn GTF2H4 Q9VUR1 Reactome DB_ID: 10500649 UniProt:Q9VUR1 mrn UniProt Q9VUR1 1 EQUAL 462 EQUAL Reactome Database ID Release 77 10500649 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500649 Reactome R-DME-65918 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65918.1 1 Xpd ERCC2 Q7KVP9 Reactome DB_ID: 10500629 UniProt:Q7KVP9 Xpd UniProt Q7KVP9 1 EQUAL 760 EQUAL Reactome Database ID Release 77 10500629 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500629 Reactome R-DME-67443 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-67443.1 1 Reactome Database ID Release 77 10500661 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10500661 Reactome R-DME-109634 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109634.1 1 Spt6 SUPT6H Q9W420 Reactome DB_ID: 10503944 UniProt:Q9W420 Spt6 UniProt Q9W420 2 EQUAL 1726 EQUAL Reactome Database ID Release 77 10503944 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503944 Reactome R-DME-8932908 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932908.1 1 IWS1 Dmel\CG9915 A8JV07 Reactome DB_ID: 10503939 UniProt:A8JV07 Dmel\CG9915 UniProt A8JV07 1 EQUAL 819 EQUAL Reactome Database ID Release 77 10503939 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503939 Reactome R-DME-8932911 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932911.1 1 FACT complex Reactome DB_ID: 10503879 dre4 SUPT16H Q8IRG6 Reactome DB_ID: 10503877 UniProt:Q8IRG6 dre4 UniProt Q8IRG6 2 EQUAL 1047 EQUAL Reactome Database ID Release 77 10503877 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503877 Reactome R-DME-112415 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112415.1 1 Ssrp SSRP1 Q05344 Reactome DB_ID: 10503872 UniProt:Q05344 Ssrp UniProt Q05344 2 EQUAL 709 EQUAL Reactome Database ID Release 77 10503872 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503872 Reactome R-DME-65105 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65105.1 1 Reactome Database ID Release 77 10503879 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503879 Reactome R-DME-112417 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112417.1 1 Early elongation complex with hyperphosphorylated Pol II CTD Reactome DB_ID: 10503862 Fcp1 CTDP1 Q9W147 Reactome DB_ID: 10503839 UniProt:Q9W147 Fcp1 UniProt Q9W147 1 EQUAL 961 EQUAL Reactome Database ID Release 77 10503839 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503839 Reactome R-DME-113416 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113416.1 1 Ell ELL Q9VW51 Reactome DB_ID: 10503858 UniProt:Q9VW51 Ell UniProt Q9VW51 1 EQUAL 621 EQUAL Reactome Database ID Release 77 10503858 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503858 Reactome R-DME-54257 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-54257.1 1 P-TEFb complex Reactome DB_ID: 10503805 Cdk9 CDK9 O17432 Reactome DB_ID: 10503789 UniProt:O17432 Cdk9 UniProt O17432 1 EQUAL 372 EQUAL Reactome Database ID Release 77 10503789 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503789 Reactome R-DME-51801 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-51801.1 1 Converted from EntitySet in Reactome CCNT1,CCNT2,CCNK Reactome DB_ID: 10503803 CycK CCNK Q961D1 Reactome DB_ID: 10503794 UniProt:Q961D1 CycK UniProt Q961D1 1 EQUAL 580 EQUAL Reactome Database ID Release 77 10503794 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503794 Reactome R-DME-6796619 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6796619.1 CycT CCNT1 O96433 Reactome DB_ID: 10503799 UniProt:O96433 CycT UniProt O96433 1 EQUAL 726 EQUAL Reactome Database ID Release 77 10503799 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503799 Reactome R-DME-51611 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-51611.1 Reactome Database ID Release 77 10503803 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503803 Reactome R-DME-6807466 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-6807466.1 1 Reactome Database ID Release 77 10503805 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503805 Reactome R-DME-112431 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112431.1 1 template:capped transcript hybrid Reactome DB_ID: 113424 Reactome Database ID Release 77 113424 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113424 Reactome R-ALL-113424 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113424.2 ChEBI 61120 1 Ghost homologue of MLLT3 Reactome DB_ID: 10503853 Reactome Database ID Release 77 10503853 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503853 Reactome R-DME-8932789 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932789.1 1 Eaf EAF2 Q7JRJ1 Reactome DB_ID: 10503851 UniProt:Q7JRJ1 Eaf UniProt Q7JRJ1 1 EQUAL 260 EQUAL Reactome Database ID Release 77 10503851 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503851 Reactome R-DME-8932790 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932790.1 1 RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex Reactome DB_ID: 10503784 RNA Polymerase II holoenzyme complex (hyperphosphorylated) Reactome DB_ID: 10503782 RpII18 POLR2F Q24320 Reactome DB_ID: 10498730 UniProt:Q24320 RpII18 UniProt Q24320 2 EQUAL 127 EQUAL Reactome Database ID Release 77 10498730 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498730 Reactome R-DME-83714 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-83714.1 1 Rpb4 POLR2D Q9VEA5 Reactome DB_ID: 10498700 UniProt:Q9VEA5 Rpb4 UniProt Q9VEA5 1 EQUAL 142 EQUAL Reactome Database ID Release 77 10498700 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498700 Reactome R-DME-63508 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63508.1 1 Rpb5 POLR2E Q7JZF5 Reactome DB_ID: 10498725 UniProt:Q7JZF5 Rpb5 UniProt Q7JZF5 1 EQUAL 210 EQUAL Reactome Database ID Release 77 10498725 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498725 Reactome R-DME-83713 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-83713.1 1 Rpb3 POLR2C O97183 Reactome DB_ID: 10498710 UniProt:O97183 Rpb3 UniProt O97183 2 EQUAL 275 EQUAL Reactome Database ID Release 77 10498710 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498710 Reactome R-DME-63506 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63506.1 1 Rpb7 POLR2G Q9VFB5 Reactome DB_ID: 10498705 UniProt:Q9VFB5 Rpb7 UniProt Q9VFB5 1 EQUAL 172 EQUAL Reactome Database ID Release 77 10498705 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498705 Reactome R-DME-63517 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63517.1 1 Rpb10 POLR2L Q9VC49 Reactome DB_ID: 10498735 UniProt:Q9VC49 Rpb10 UniProt Q9VC49 1 EQUAL 67 EQUAL Reactome Database ID Release 77 10498735 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498735 Reactome R-DME-83715 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-83715.1 1 P04052 phospho-RpII215 p-S2,S5-POLR2A Reactome DB_ID: 10503780 UniProt:P04052 RpII215 UniProt P04052 5 EQUAL O-phospho-L-serine MOD MOD:00046 2 EQUAL 1 EQUAL 1970 EQUAL Reactome Database ID Release 77 10503780 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503780 Reactome R-DME-113420 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113420.1 1 Rpb8 POLR2H Q9VNZ3 Reactome DB_ID: 10498715 UniProt:Q9VNZ3 Rpb8 UniProt Q9VNZ3 2 EQUAL 150 EQUAL Reactome Database ID Release 77 10498715 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498715 Reactome R-DME-63523 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63523.1 1 Rpb12 POLR2K Q6IGE3 Reactome DB_ID: 10498720 UniProt:Q6IGE3 Rpb12 UniProt Q6IGE3 1 EQUAL 58 EQUAL Reactome Database ID Release 77 10498720 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498720 Reactome R-DME-63537 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63537.1 1 POLR2B RpII140 P08266 Reactome DB_ID: 10498695 UniProt:P08266 RpII140 UniProt P08266 1 EQUAL 1174 EQUAL Reactome Database ID Release 77 10498695 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498695 Reactome R-DME-63504 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63504.1 1 Rpb11 POLR2J Q9VJE4 Reactome DB_ID: 10498685 UniProt:Q9VJE4 Rpb11 UniProt Q9VJE4 1 EQUAL 117 EQUAL Reactome Database ID Release 77 10498685 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498685 Reactome R-DME-63531 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63531.1 1 RpII15 POLR2I P36958 Reactome DB_ID: 10498690 UniProt:P36958 RpII15 UniProt P36958 1 EQUAL 125 EQUAL Reactome Database ID Release 77 10498690 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498690 Reactome R-DME-63525 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-63525.1 1 Reactome Database ID Release 77 10503782 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503782 Reactome R-DME-109909 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109909.1 1 TFIIF Reactome DB_ID: 10498749 GTF2F1 TfIIFalpha Q05913 Reactome DB_ID: 10498742 UniProt:Q05913 TfIIFalpha UniProt Q05913 2 EQUAL 517 EQUAL Reactome Database ID Release 77 10498742 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498742 Reactome R-DME-65565 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65565.1 1 GTF2F2 TfIIFbeta P41900 Reactome DB_ID: 10498747 UniProt:P41900 TfIIFbeta UniProt P41900 2 EQUAL 249 EQUAL Reactome Database ID Release 77 10498747 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498747 Reactome R-DME-65567 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-65567.1 1 Reactome Database ID Release 77 10498749 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10498749 Reactome R-DME-109631 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-109631.1 1 Reactome Database ID Release 77 10503784 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503784 Reactome R-DME-113425 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113425.1 1 DSIF complex Reactome DB_ID: 10503834 spt4 SUPT4H1 Q9TVQ5 Reactome DB_ID: 10503832 UniProt:Q9TVQ5 spt4 UniProt Q9TVQ5 1 EQUAL 117 EQUAL Reactome Database ID Release 77 10503832 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503832 Reactome R-DME-64905 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-64905.1 1 Q9V460 phospho-Spt5 p-SUPT5H Reactome DB_ID: 10502421 UniProt:Q9V460 Spt5 UniProt Q9V460 phosphorylated residue MOD MOD:00696 1 EQUAL 1087 EQUAL Reactome Database ID Release 77 10502421 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10502421 Reactome R-DME-3009372 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-3009372.1 1 Reactome Database ID Release 77 10503834 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503834 Reactome R-DME-112420 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112420.1 1 AFF4 lilli Q9VQI9 Reactome DB_ID: 10503844 UniProt:Q9VQI9 lilli UniProt Q9VQI9 1 EQUAL 1163 EQUAL Reactome Database ID Release 77 10503844 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503844 Reactome R-DME-8932788 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932788.1 1 NELF complex Reactome DB_ID: 10503827 NELFA Nelf-A Q86NP2 Reactome DB_ID: 10503810 UniProt:Q86NP2 Nelf-A UniProt Q86NP2 1 EQUAL 528 EQUAL Reactome Database ID Release 77 10503810 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503810 Reactome R-DME-112426 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112426.1 1 NELFB NELF-B Q9Y113 Reactome DB_ID: 10503815 UniProt:Q9Y113 NELF-B UniProt Q9Y113 1 EQUAL 580 EQUAL Reactome Database ID Release 77 10503815 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503815 Reactome R-DME-112427 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112427.1 1 TH1 NELFCD Q24134 Reactome DB_ID: 10503820 UniProt:Q24134 TH1 UniProt Q24134 1 EQUAL 590 EQUAL Reactome Database ID Release 77 10503820 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503820 Reactome R-DME-112428 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112428.1 1 NELFE Nelf-E P92204 Reactome DB_ID: 10503825 UniProt:P92204 Nelf-E UniProt P92204 1 EQUAL 380 EQUAL Reactome Database ID Release 77 10503825 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503825 Reactome R-DME-62907 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-62907.1 1 Reactome Database ID Release 77 10503827 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503827 Reactome R-DME-112432 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112432.1 1 Ghost homologue of MLLT1 Reactome DB_ID: 10503860 Reactome Database ID Release 77 10503860 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503860 Reactome R-DME-8932918 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932918.1 1 Eaf EAF1 Q7JRJ1 Reactome DB_ID: 10503849 1 EQUAL 268 EQUAL Reactome Database ID Release 77 10503849 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503849 Reactome R-DME-8932787 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8932787.1 1 Reactome Database ID Release 77 10503862 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503862 Reactome R-DME-113426 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113426.1 1 Reactome Database ID Release 77 10503946 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503946 Reactome R-DME-112433 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112433.1 前进的伸长复杂 Reactome DB_ID: 10503961 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Elongating transcript in processive Pol II mediated elongation Reactome DB_ID: 113717 Reactome Database ID Release 77 113717 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113717 Reactome R-ALL-113717 2 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113717.2 ChEBI 33697 1 1 1 1 Reactome Database ID Release 77 10503961 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503961 Reactome R-DME-113719 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-113719.1 Reactome Database ID Release 77 10503963 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10503963 Reactome R-DME-112385 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-112385.1 High-resolution structures of free, catalytically active yeast Pol II and of an elongating form reveal that Pol II elongation complex includes features like:
- RNA-DNA hybrid, an unwound template ahead of 3'-OH terminus of growing transcript and an exit groove at the base of the CTD, possibly for dynamic interaction of processing and transcriptional factors.
- a cleft or channel created by Rpb1 and Rpb2 subunits to accommodate DNA template, extending to Mg2+ ion located deep in the enzyme core
-a 50 kDa "clamp" with open confirmation in free polymerase, allowing entry of DNA strands but closed in the processive elongation phase.
The clamp is composed of portions of Rpb1,Rpb2 and Rpb3 , five loops or "switches" that change from unfolded to well-folded structures stabilizing the elongation complex, and a long "bridging helix" that emanates from Rpb1 subunit, crossing near the Mg2+ ion. The bridging helix is thought to "bend" to push on the base pair at the 3'-end of RNA-DNA hybrid like a ratchet, translocating Pol II along the DNA (Cramer et al.,2001; Gnatt et al.,2001).In addition to its dynamic biochemical potential, Pol II possess a repertoire of functions to serve as a critical platform of recruiting and coordinating the actions of a host of additional enzyme and proteins involved in various pathways.
11313498 Pubmed 2001 Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer, P Bushnell, DA Kornberg, RD Science 292:1863-76 11313499 Pubmed 2001 Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Gnatt, AL Cramer, P Fu, J Bushnell, DA Kornberg, RD Science 292:1876-82 inferred from electronic annotation EVIDENCE CODE ECO:0000203