The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex Reactome DB_ID: 10334193 cytosol GENE ONTOLOGY GO:0005829 CDC20:p-APC/C Reactome DB_ID: 10334191 phosphorylated anaphase promoting complex (APC/C) Reactome DB_ID: 10325255 Ghost homologue of ANAPC11 Reactome DB_ID: 10325241 Reactome Database ID Release 77 10325241 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325241 Reactome R-XTR-174126 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174126.1 Reactome //www.joaskin.com 1 anapc5 ANAPC5 A0A6I8PQD8 Reactome DB_ID: 10325215 UniProt:A0A6I8PQD8 anapc5 Xenopus tropicalis NCBI Taxonomy 8364 UniProt A0A6I8PQD8 1 EQUAL 755 EQUAL Reactome Database ID Release 77 10325215 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325215 Reactome R-XTR-174211 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174211.1 1 UBE2E1 A0A7D9NKV6 Reactome DB_ID: 10325233 UniProt:A0A7D9NKV6 UniProt A0A7D9NKV6 2 EQUAL 193 EQUAL Reactome Database ID Release 77 10325233 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325233 Reactome R-XTR-174100 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174100.1 1 Q28GX7 anapc10 ANAPC10 Reactome DB_ID: 10325201 UniProt:Q28GX7 anapc10 UniProt Q28GX7 1 EQUAL 185 EQUAL Reactome Database ID Release 77 10325201 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325201 Reactome R-XTR-174142 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174142.1 1 cdc16 CDC16 A0A6I8RN40 Reactome DB_ID: 10325219 UniProt:A0A6I8RN40 cdc16 UniProt A0A6I8RN40 1 EQUAL 620 EQUAL Reactome Database ID Release 77 10325219 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325219 Reactome R-XTR-174156 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174156.1 1 anapc2 ANAPC2 F7DMN6 Reactome DB_ID: 10325205 UniProt:F7DMN6 anapc2 UniProt F7DMN6 1 EQUAL 822 EQUAL Reactome Database ID Release 77 10325205 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325205 Reactome R-XTR-174229 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174229.1 1 anapc1 ANAPC1 Q08D52 Reactome DB_ID: 10325197 UniProt:Q08D52 anapc1 UniProt Q08D52 1 EQUAL 1944 EQUAL Reactome Database ID Release 77 10325197 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325197 Reactome R-XTR-174189 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174189.1 1 A9JSB3 anapc15 ANAPC15 Reactome DB_ID: 10325245 UniProt:A9JSB3 anapc15 UniProt A9JSB3 1 EQUAL 121 EQUAL Reactome Database ID Release 77 10325245 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325245 Reactome R-XTR-6805140 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6805140.1 1 Ghost homologue of CDC26 Reactome DB_ID: 10325229 Reactome Database ID Release 77 10325229 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325229 Reactome R-XTR-174052 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174052.1 1 Ghost homologue of ANAPC4 Reactome DB_ID: 10325211 Reactome Database ID Release 77 10325211 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325211 Reactome R-XTR-174168 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174168.1 1 ube2d1 UBE2D1 A0A6I8RK03 Reactome DB_ID: 10325239 UniProt:A0A6I8RK03 ube2d1 UniProt A0A6I8RK03 1 EQUAL 147 EQUAL Reactome Database ID Release 77 10325239 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325239 Reactome R-XTR-174236 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174236.1 1 ube2s UBE2S Q28F89 Reactome DB_ID: 10325253 UniProt:Q28F89 ube2s UniProt Q28F89 1 EQUAL 222 EQUAL Reactome Database ID Release 77 10325253 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325253 Reactome R-XTR-947622 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-947622.1 1 cdc23 CDC23 A0A6I8RVH0 Reactome DB_ID: 10325227 UniProt:A0A6I8RVH0 cdc23 UniProt A0A6I8RVH0 1 EQUAL 597 EQUAL Reactome Database ID Release 77 10325227 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325227 Reactome R-XTR-174137 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174137.1 1 cdc27 CDC27 A0A6I8Q506 Reactome DB_ID: 10325209 UniProt:A0A6I8Q506 cdc27 UniProt A0A6I8Q506 1 EQUAL 824 EQUAL Reactome Database ID Release 77 10325209 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325209 Reactome R-XTR-174073 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174073.1 1 anapc7 ANAPC7 F6ZZM9 Reactome DB_ID: 10325223 UniProt:F6ZZM9 anapc7 UniProt F6ZZM9 1 EQUAL 599 EQUAL Reactome Database ID Release 77 10325223 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325223 Reactome R-XTR-174242 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174242.1 1 Ghost homologue of UBE2C Reactome DB_ID: 10325235 Reactome Database ID Release 77 10325235 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325235 Reactome R-XTR-174244 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174244.1 1 Q6DJQ9 anapc16 ANAPC16 Reactome DB_ID: 10325249 UniProt:Q6DJQ9 anapc16 UniProt Q6DJQ9 2 EQUAL 110 EQUAL Reactome Database ID Release 77 10325249 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325249 Reactome R-XTR-6805138 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6805138.1 1 Reactome Database ID Release 77 10325255 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325255 Reactome R-XTR-174191 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174191.1 1 cdc20 CDC20 F6UE96 Reactome DB_ID: 10331823 UniProt:F6UE96 cdc20 UniProt F6UE96 1 EQUAL 499 EQUAL Reactome Database ID Release 77 10331823 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10331823 Reactome R-XTR-141412 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-141412.1 1 Reactome Database ID Release 77 10334191 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10334191 Reactome R-XTR-174081 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174081.1 1 CCNB1:p-T161-CDK1 Reactome DB_ID: 10333812 CCNB1 ccnb1.2 F6QF79 Reactome DB_ID: 10333744 UniProt:F6QF79 ccnb1.2 UniProt F6QF79 1 EQUAL 433 EQUAL Reactome Database ID Release 77 10333744 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10333744 Reactome R-XTR-157451 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-157451.1 1 Q6P7L3 phospho-cdk1 p-T161-CDK1 Reactome DB_ID: 10330667 UniProt:Q6P7L3 cdk1 UniProt Q6P7L3 161 EQUAL O-phospho-L-threonine MOD MOD:00047 1 EQUAL 297 EQUAL Reactome Database ID Release 77 10330667 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10330667 Reactome R-XTR-157415 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-157415.1 1 Reactome Database ID Release 77 10333812 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10333812 Reactome R-XTR-157456 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-157456.1 1 Reactome Database ID Release 77 10334193 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10334193 Reactome R-XTR-174095 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174095.1 Converted from EntitySet in Reactome Ub ubiquitin Reactome DB_ID: 10325172 mrpl3 RPS27A(1-76) Q28I48 Reactome DB_ID: 10325164 UniProt:Q28I48 mrpl3 UniProt Q28I48 1 EQUAL 76 EQUAL Reactome Database ID Release 77 10325164 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325164 Reactome R-XTR-939205 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-939205.1 ubc UBA52(1-76) A0A6I8RD22 Reactome DB_ID: 10325166 UniProt:A0A6I8RD22 ubc UniProt A0A6I8RD22 1 EQUAL 76 EQUAL Reactome Database ID Release 77 10325166 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325166 Reactome R-XTR-939203 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-939203.1 Reactome Database ID Release 77 10325172 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325172 Reactome R-XTR-113595 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-113595.1 4 multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex Reactome DB_ID: 10334238 1 4 Reactome Database ID Release 77 10334238 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10334238 Reactome R-XTR-174131 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174131.1 ACTIVATION GENE ONTOLOGY GO:0004842 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 10334234 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10334234 Reactome Database ID Release 77 10334255 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10334255 Reactome R-XTR-174227 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-174227.1 GENE ONTOLOGY GO:0006511 gene ontology term for cellular process MI MI:0359 At the beginning of this reaction, 1 molecule of 'Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex', and 3 molecules of 'ubiquitin' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'Cdc20:Phospho-APC/C'.
11285280 Pubmed 2001 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint Geley, S Kramer, E Gieffers, C Gannon, J Peters, JM Hunt, T J Cell Biol 153:137-48 inferred from electronic annotation EVIDENCE CODE ECO:0000203