BioPAX pathway converted from "PI5P Regulates TP53 Acetylation" in the Reactome database. PI5P Regulates TP53 Acetylation This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LEFT-TO-RIGHT TMEM55B把原子核 This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Q32PR0 tmem55ba TMEM55B Reactome DB_ID: 10303839 late endosome membrane GENE ONTOLOGY GO:0031902 UniProt:Q32PR0 tmem55ba Danio rerio NCBI Taxonomy 7955 UniProt Q32PR0 1 EQUAL 277 EQUAL Reactome Database ID Release 77 10303839 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303839 Reactome R-DRE-6810395 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810395.1 Reactome //www.joaskin.com Q32PR0 tmem55ba TMEM55B Reactome DB_ID: 10303841 nucleoplasm GENE ONTOLOGY GO:0005654 1 EQUAL 277 EQUAL Reactome Database ID Release 77 10303841 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303841 Reactome R-DRE-6810405 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810405.1 Reactome Database ID Release 77 10303843 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303843 Reactome R-DRE-6810392 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810392.1 Under conditions of cellular stress, TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) translocates to the nucleus through an unknown mechanism (Zou et al. 2007). 17940011 Pubmed 2007 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Zou, J Marjanovic, Jasna Kisseleva, Marina V Wilson, Monita Majerus, PW Proc. Natl. Acad. Sci. U.S.A. 104:16834-9 inferred from electronic annotation EVIDENCE CODE ECO:0000203 LEFT-TO-RIGHT 3.1.3.66 PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PI(4,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Reactome DB_ID: 6810412 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate PIP2 ChEBI CHEBI:18348 Reactome Database ID Release 77 6810412 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6810412 Reactome R-ALL-6810412 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6810412.3 H2O water Reactome DB_ID: 113518 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 77 113518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113518 Reactome R-ALL-113518 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113518.3 COMPOUND C00001 additional information MI MI:0361 Pi Orthophosphate hydrogenphosphate Phosphate Inorganic Phosphate Reactome DB_ID: 113550 hydrogenphosphate [ChEBI:43474] hydrogenphosphate hydrogen phosphate phosphate [PO3(OH)](2-) INORGANIC PHOSPHATE GROUP HYDROGENPHOSPHATE离子 HPO4(2-) [P(OH)O3](2-) ChEBI CHEBI:43474 Reactome Database ID Release 77 113550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113550 Reactome R-ALL-113550 4 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113550.4 COMPOUND C00009 PI5P 1-phosphatidyl-1D-myo-inositol 5-phosphate Reactome DB_ID: 6810408 1-phosphatidyl-1D-myo-inositol 5-phosphate [ChEBI:16500] 1-phosphatidyl-1D-myo-inositol 5-phosphate PI5P ChEBI CHEBI:16500 Reactome Database ID Release 77 6810408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=6810408 Reactome R-ALL-6810408 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-6810408.3 ACTIVATION GENE ONTOLOGY GO:0034597 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 10303844 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303844 Reactome Database ID Release 77 10303846 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303846 Reactome R-DRE-6810410 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810410.1 Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010). 9843587 Pubmed 1998 Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors Boronenkov, I V Loijens, J C Umeda, M Anderson, R A Mol. Biol. Cell 9:3547-60 19846310 Pubmed 2010 Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum Barlow, Christy A Laishram, Rakesh S Anderson, Richard A Trends Cell Biol. 20:25-35 LEFT-TO-RIGHT 2.7.1.149 PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 29358 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 29358 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29358 Reactome R-ALL-29358 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29358.3 COMPOUND C00002 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 113582 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 113582 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113582 Reactome R-ALL-113582 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113582.3 COMPOUND C00008 ACTIVATION Converted from EntitySet in Reactome PIP4K2 dimers Reactome DB_ID: 10304134 PIP4K2A:PIP4K2A Reactome DB_ID: 10304126 PIP4K2A pip4k2aa A0A2R8RVI8 Reactome DB_ID: 10304124 UniProt: A0A2R8RVI8 pip4k2aa UniProt A0A2R8RVI8 2 EQUAL 406 EQUAL Reactome Database ID Release 77 10304124 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304124 Reactome r -衣服6811484 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811484.1 2 Reactome Database ID Release 77 10304126 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304126 Reactome R-DRE-6811460 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811460.1 PIP4K2A:PIP4K2C Reactome DB_ID: 10304130 1 Q6IQE1 pip4k2c PIP4K2C Reactome DB_ID: 10304128 UniProt:Q6IQE1 pip4k2c UniProt Q6IQE1 2 EQUAL 421 EQUAL Reactome Database ID Release 77 10304128 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304128 Reactome R-DRE-6811499 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811499.1 1 Reactome Database ID Release 77 10304130 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304130 Reactome R-DRE-6811465 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811465.1 PIP4K2C:PIP4K2C Reactome DB_ID: 10304132 2 Reactome Database ID Release 77 10304132 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304132 Reactome R-DRE-6811471 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811471.1 Reactome Database ID Release 77 10304134 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304134 Reactome R-DRE-6811466 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811466.1 GENE ONTOLOGY GO:0016309 Reactome Database ID Release 77 10304135 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304135 Reactome Database ID Release 77 10304137 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304137 Reactome R-DRE-6811522 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811522.1 In the nucleus, phosphatidylinositol 5-phosphate (PI5P) is phosphorylated to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) mainly by phosphatidylinositol-5-phosphate 4-kinase type-2 beta (PIP4K2B). In the nucleus, PIP4K2B predominantly functions as a homodimer or a heterodimer with PIP4K2A. A low level of PIP4K2A homodimers can also be found in the nucleus. Nuclear localization of PIP4K2C has not been examined but is assumed to be possible, at least through formation of heterodimers with PIP4K2B (Ciruela et al. 2000, Jones et al. 2006, Bultsma et al. 2010). Under conditions of cellular stress, nuclear PIP4K2B can be phosphorylated by p38 MAP kinases, resulting in PIP4K2B inactivation. The putative p38 target site, serine residue S326 of PIP4K2B, is conserved in PIP4K2A, but the role and mechanism of p38-mediated regulation of PIP4K2 isoforms has not been studied in detail (Jones et al. 2006). 16949365 Pubmed 2006 Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta Jones, David R Bultsma, Yvette Keune, Willem-Jan Halstead, Jonathan R Elouarrat, Dallila Mohammed, Shabaz Heck, Albert J D'Santos, Clive S Divecha, Nullin Mol. Cell 23:685-95 20583997 Pubmed 2010 PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha Bultsma, Yvette Keune, Willem-Jan Divecha, Nullin Biochem. J. 430:223-35 10698683 Pubmed 2000 Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7 Ciruela, A Hinchliffe, K A Divecha, Nullin Irvine, R F Biochem. J. 346:587-91 LEFT-TO-RIGHT ING2 binds PI5P This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ing2 ING2 Q6DHF1 Reactome DB_ID: 10278464 UniProt:Q6DHF1 ing2 UniProt Q6DHF1 1 EQUAL 280 EQUAL Reactome Database ID Release 77 10278464 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10278464 Reactome r -衣服3215167 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3215167.1 ING2:PI5P Reactome DB_ID: 10303833 nuclear envelope GENE ONTOLOGY GO:0005635 1 1 Reactome Database ID Release 77 10303833 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303833 Reactome R-DRE-6810382 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810382.1 Reactome Database ID Release 77 10303835 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10303835 Reactome R-DRE-6810376 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6810376.1 The PHD finger of ING2 binds phosphatidylinositol-5-phosphate (PI5P) (Gozani et al. 2003), which promotes nuclear retention of ING2 (Jones et al. 2006, Zou et al. 2007). 12859901 Pubmed 2003 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor Gozani, Or Karuman, Philip Jones, David R Ivanov, Dmitri Cha, James Lugovskoy, Alexey A Baird, Cheryl L Zhu, Hong Field, Seth J Lessnick, Stephen L Villasenor, Jennifer Mehrotra, Bharat Chen, Jian Rao, Vikram R Brugge, Joan S Ferguson, Colin G Payrastre, Bernard Myszka, David G Cantley, Lewis C Wagner, Gerhard Divecha, Nullin Prestwich, Glenn D Yuan, Junying Cell 114:99-111 LEFT-TO-RIGHT ING2 recruits EP300 to TP53 This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp EP300 ep300b X1WG57 Reactome DB_ID: 10247994 UniProt:X1WG57 ep300b UniProt X1WG57 2 EQUAL 2414 EQUAL Reactome Database ID Release 77 10247994 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10247994 Reactome R-DRE-381325 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-381325.1 p-S15,S20-TP53 Tetramer Reactome DB_ID: 10206552 P79734 phospho-tp53 p-S15,S20-TP53 Reactome DB_ID: 10206550 UniProt:P79734 tp53 UniProt P79734 20 EQUAL O-phospho-L-serine MOD MOD:00046 15 EQUAL 1 EQUAL 393 EQUAL Reactome Database ID Release 77 10206550 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10206550 Reactome R-DRE-69683 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-69683.1 4 Reactome Database ID Release 77 10206552 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10206552 Reactome R-DRE-3222171 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3222171.1 ING2: EP300: p-S15 S20-TP53四聚物 Reactome DB_ID: 10304112 1 1 1 Reactome Database ID Release 77 10304112 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304112 Reactome R-DRE-3215194 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-3215194.1 Reactome Database ID Release 77 10304114 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304114 Reactome R-DRE-6811479 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811479.1 ING2 recruits histone acetyltransferase EP300 (p300) to TP53 (Padeux et al. 2005). 16024799 Pubmed 2005 ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation Pedeux, Remy Sengupta, Sagar Shen, Jiang Cheng Demidov, Oleg N Saito, Shin'ichi Onogi, Hitoshi Kumamoto, Kensuke Wincovitch, Stephen Garfield, Susan H McMenamin, Mary Nagashima, Makoto Grossman, Steven R Appella, E Harris, Curtis C 摩尔。细胞。生物25:6639-48 LEFT-TO-RIGHT ING2-bound EP300 acetylates TP53 This event has been computationally inferred from an event that has been demonstrated in another species.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Ac-CoA Acetyl coenzyme A acetyl-CoA Reactome DB_ID: 113560 acetyl-CoA [ChEBI:15351] acetyl-CoA ChEBI CHEBI:15351 Reactome Database ID Release 77 113560 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113560 Reactome R-ALL-113560 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113560.3 COMPOUND C00024 4 CoA CoA-SH coenzyme A Reactome DB_ID: 2485002 coenzyme A [ChEBI:15346] coenzyme A ChEBI CHEBI:15346 Reactome Database ID Release 77 2485002 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2485002 Reactome R-ALL-2485002 3 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-2485002.3 COMPOUND C00010 4 ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer Reactome DB_ID: 10304119 1 Ac-K382,p-S15,S20-TP53 Tetramer Reactome DB_ID: 10285397 P79734 phospho-tp53 Ac-K382,p-S15,S20-TP53 Reactome DB_ID: 10285395 382 EQUAL N6-acetyl-L-lysine MOD MOD:00064 1 EQUAL 393 EQUAL Reactome Database ID Release 77 10285395 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10285395 Reactome R-DRE-5628868 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5628868.1 4 Reactome Database ID Release 77 10285397 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10285397 Reactome R-DRE-5628873 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-5628873.1 1 1 Reactome Database ID Release 77 10304119 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304119 Reactome R-DRE-6811488 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811488.1 ACTIVATION activeUnit: #Protein6 GENE ONTOLOGY GO:0061733 Reactome Database ID Release 77 10304120 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304120 Reactome Database ID Release 77 10304122 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10304122 Reactome R-DRE-6811508 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811508.1 The histone acetyltransferase EP300 (p300), recruited to TP53 (p53) by ING2, acetylates TP53 on lysine residue K382, which may contribute to TP53-dependent apoptosis (Padeux et al. 2005). PI5P positively regulates TP53 acetylation (Zou et al. 2007), possibly by increasing the amount of ING2 in the nucleus (Gozani et al. 2003). ACTIVATION Reactome Database ID Release 77 8877675 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=8877675 Reactome R-HSA-8877675 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8877675.1 Reactome Database ID Release 77 10323996 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10323996 Reactome R-DRE-6811555 1 Reactome稳定的标识符。使用this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-6811555.1 Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010).