The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp 左吨O-RIGHT LDL binds to LRP8 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp LDL Reactome DB_ID: 9966634 extracellular region GENE ONTOLOGY GO:0005576 APOB APOB(28-4563) F1P8Z5 Reactome DB_ID: 9966632 UniProt:F1P8Z5 APOB Canis familiaris NCBI Taxonomy 9615 UniProt F1P8Z5 28 EQUAL 4563 EQUAL Reactome Database ID Release 77 9966632 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9966632 Reactome R-CFA-171065 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-171065.1 Reactome //www.joaskin.com 1 CHEST cholesterol ester cholesteryl ester cholesterol esters Reactome DB_ID: 171076 cholesteryl ester [ChEBI:17002] cholesteryl ester ChEBI CHEBI:17002 Reactome Database ID Release 77 171076 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=171076 Reactome R-ALL-171076 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-171076.3 1500 TAGs triacylglycerols triglyceride Reactome DB_ID: 171126 triglyceride [ChEBI:17855] triglyceride ChEBI CHEBI:17855 Reactome Database ID Release 77 171126 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=171126 Reactome R-ALL-171126 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-171126.3 170 CHOL cholesterol Reactome DB_ID: 171149 cholesterol [ChEBI:16113] cholesterol cholest-5-en-3beta-ol ChEBI CHEBI: 16113 Reactome Database ID Release 77 171149 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=171149 Reactome R-ALL-171149 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-171149.3 670 PL phospholipids phospholipid Reactome DB_ID: 171066 phospholipid [ChEBI:16247] phospholipid ChEBI CHEBI:16247 Reactome Database ID Release 77 171066 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=171066 Reactome R-ALL-171066 3 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-171066.3 690 Reactome Database ID Release 77 9966634 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9966634 Reactome R-CFA-171131 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-171131.1 LRP8 LRP8 A0A5F4D4Q6 Reactome DB_ID: 9984199 plasma membrane GENE ONTOLOGY GO:0005886 UniProt:A0A5F4D4Q6 LRP8 UniProt A0A5F4D4Q6 33 EQUAL 963 EQUAL Reactome Database ID Release 77 9984199 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984199 Reactome R-CFA-432113 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432113.1 LDL:LRP8 Reactome DB_ID: 9984201 1 1 Reactome Database ID Release 77 9984201 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984201 Reactome R-CFA-432119 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432119.1 Reactome Database ID Release 77 9984203 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984203 Reactome R-CFA-432121 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432121.1 LPR8 (apoER2) is the platelet low density lipoprotein (LDL) receptor. Mice lacking ApoE develop hypercholesterolemia and later atherosclerosis (Zhang et al. 1992). Similiar results are seen in familial hypercholesterolemia, where defective apoB/E receptors fail to remove LDL from the circulation. 1411543 Pubmed 1992 Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E Zhang, SH Reddick, RL Piedrahita, JA Maeda, N Science 258:468-71 15459198 Pubmed 2004 Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK Korporaal, SJ Relou, IA van Eck, M Strasser, V Bezemer, M Gorter, G van Berkel, TJ Nimpf, J Akkerman, Jan Willem N Lenting, PJ J Biol Chem 279:52526-34 inferred from electronic annotation EVIDENCE CODE ECO:0000203 左吨O-RIGHT FGR binds LDL:LRP8 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp FGR FGR E2RSN0 Reactome DB_ID: 9984207 cytosol GENE ONTOLOGY GO:0005829 UniProt:E2RSN0 FGR UniProt E2RSN0 1 EQUAL 529 EQUAL Reactome Database ID Release 77 9984207 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984207 Reactome R-CFA-432116 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432116.1 LDL:LRP8:FGR Reactome DB_ID: 9984209 1 1 Reactome Database ID Release 77 9984209 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984209 Reactome R-CFA-8948036 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8948036.1 Reactome Database ID Release 77 10036671 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10036671 Reactome R-CFA-8948034 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8948034.1 Tyrosine phosphorylation of LDL:LRP8 is mediated by the Src-family kinase FGR, based on a correlation of increased LRP8 phosphorylation in LDL-stimulated platelets and a transient increased co-precipitation of FGR and LRP8 upon LDL stimulation. 左吨O-RIGHT 2.7.10 FGR binds and phosphorylates LRP8 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp ATP Adenosine 5'-triphosphate ATP(4-) Reactome DB_ID: 113592 ATP(4-) [ChEBI:30616] ATP(4-) ATP atp Adenosine 5'-triphosphate ChEBI CHEBI:30616 Reactome Database ID Release 77 113592 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=113592 Reactome R-ALL-113592 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113592.5 COMPOUND C00002 additional information MI MI:0361 ADP Adenosine 5'-diphosphate ADP(3-) Reactome DB_ID: 29370 ADP(3-) [ChEBI:456216] ADP(3-) ADP 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP trianion ChEBI CHEBI:456216 Reactome Database ID Release 77 29370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=29370 Reactome R-ALL-29370 5 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29370.5 COMPOUND C00008 LDL:p-LRP8:FGR Reactome DB_ID: 9984216 LDL:p-LRP8 Reactome DB_ID: 9984214 1 p-Y-LRP8 phospho-LRP8 A0A5F4D4Q6 Reactome DB_ID: 9984212 O4'-phospho-L-tyrosine MOD MOD:00048 33 EQUAL 963 EQUAL Reactome Database ID Release 77 9984212 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984212 Reactome R-CFA-432136 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432136.1 1 Reactome Database ID Release 77 9984214 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984214 Reactome R-CFA-432133 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432133.1 1 1 Reactome Database ID Release 77 9984216 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984216 Reactome R-CFA-432132 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432132.1 ACTIVATION GENE ONTOLOGY GO:0004713 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 77 9984217 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984217 Reactome Database ID Release 77 9984219 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984219 Reactome R-CFA-432129 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432129.1 Tyrosine phosphorylation of LDL:LRP8 is mediated by the Src-family kinase FGR, based on a correlation of increased LRP8 phosphorylation on LDL stimulation of platelets, and a transient increased co-precipitation of FGR with LRP8 upon LDL stimulation. 左吨O-RIGHT 2.7.10.2 Fgr may phosphorylate p38 MAPK This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp MAPK14 MAPK14 O02812 Reactome DB_ID: 9983656 UniProt:O02812 MAPK14 UniProt O02812 2 EQUAL 360 EQUAL Reactome Database ID Release 77 9983656 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9983656 Reactome R-CFA-428933 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-428933.1 2 O02812 phospho-MAPK14 p-T180,Y182-MAPK14 Reactome DB_ID: 9968478 180 EQUAL O-phospho-L-threonine MOD MOD:00047 182 EQUAL 2 EQUAL 360 EQUAL Reactome Database ID Release 77 9968478 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9968478 Reactome R-CFA-428935 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-428935.1 2 ACTIVATION GENE ONTOLOGY GO:0004715 Reactome Database ID Release 77 9984224 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984224 Reactome Database ID Release 77 9984226 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984226 Reactome R-CFA-432148 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432148.1 LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved. 17339487 Pubmed 2007 The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine Fumagalli, L Zhang, H Baruzzi, A Lowell, CA Berton, G J Immunol 178:3874-85 10754332 Pubmed 2000 Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases Mocsai, A Jakus, Z Vántus, T Berton, G Lowell, CA Ligeti, E J Immunol 164:4321-31 左吨O-RIGHT 2.7.11 磷酸化cPLA2的马PK p38 alpha This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp F6UQ33 PLA2G4A PLA2G4A Reactome DB_ID: 9983660 UniProt:F6UQ33 PLA2G4A UniProt F6UQ33 1 EQUAL 749 EQUAL Reactome Database ID Release 77 9983660 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9983660 Reactome R-CFA-378502 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-378502.1 2 F6UQ33 phospho-PLA2G4A p-S505,S727-PLA2G4A Reactome DB_ID: 9961902 endoplasmic reticulum membrane GENE ONTOLOGY GO:0005789 505 EQUAL O-phospho-L-serine MOD MOD:00046 727 EQUAL 1 EQUAL 749 EQUAL Reactome Database ID Release 77 9961902 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9961902 Reactome R-CFA-111859 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-111859.1 2 ACTIVATION GENE ONTOLOGY GO:0004674 Reactome Database ID Release 77 9983661 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9983661 Reactome Database ID Release 77 9983663 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9983663 Reactome R-CFA-428961 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-428961.1 MAPK p38 alpha activates cPLA2 by phosphorylation of two serine residues.
cPLA2 can be phosphorylated and activated by ERK2 (Lin et al. 1993), and were believed to be responsible for the phosphorylation of cPLA2. However, phosphorylation of cPLA2 occurred in the absence of ERK activation in human platelets stimulated with the thrombin receptor agonist peptide SFLLRN (Kramer et al. 1995), and cPLA2 phosphorylation induced by thrombin or collagen was unaffected by PKC inhibitors that prevent ERK activation (Börsch-Haubold et al. 1995). In addition, a specific inhibitor of ERKs did not block thrombin-induced cPLA2 phosphorylation (Börsch-Haubold et al. 1996). 9468497 Pubmed 1998 Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells Börsch-Haubold, AG Bartoli, F Asselin, J Dudler, T Kramer, RM Apitz-Castro, R Watson, SP Gelb, Michael H J Biol Chem 273:4449-58 8910365 Pubmed 1996 p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2 Kramer, RM Roberts, EF Um, SL Börsch-Haubold, AG Watson, SP Fisher, MJ Jakubowski, JA J Biol Chem 271:27723-9 7782348 Pubmed 1995 Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2 Kramer, RM Roberts, EF Hyslop, PA Utterback, BG Hui, KY Jakubowski, JA J Biol Chem 270:14816-23 8761473 Pubmed 1996 Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets Börsch-Haubold, AG Kramer, RM Watson, SP Biochem J 318:207-12 8381049 Pubmed 1993 cPLA2 is phosphorylated and activated by MAP kinase Lin, LL Wartmann, M Lin, AY Knopf, JL Seth, A Davis, RJ Cell 72:269-78 7592775 Pubmed 1995 Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase Börsch-Haubold, AG Kramer, RM Watson, SP J Biol Chem 270:25885-92 左吨O-RIGHT PECAM1 is phosphorylated This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PECAM1 PECAM1 F1PYL8 Reactome DB_ID: 9972505 UniProt:F1PYL8 PECAM1 UniProt F1PYL8 28 EQUAL 738 EQUAL Reactome Database ID Release 77 9972505 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9972505 Reactome R-CFA-114686 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-114686.1 2 2 F1PYL8 phospho-PECAM1 p-Y663,Y686-PECAM1(27-?) Reactome DB_ID: 9974000 663 EQUAL 686 EQUAL 27 EQUAL -1 EQUAL Reactome Database ID Release 77 9974000 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9974000 Reactome R-CFA-210007 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-210007.1 Reactome Database ID Release 77 9984583 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984583 Reactome R-CFA-435244 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-435244.1 LDL causes a transient increase in p38 MAPK activity in platelets. After an initial phase in which LDL leads to the activation of p38MAPK, LDL leads to tyrosine phosphorylation and thereby activation of PECAM-1, which in turn leads to binding and stimulation of the Ser/Thr phosphatases PP1/PP2A which reduce the activity of p38MAPK by dephosphorylation. 12689916 Pubmed 2003 Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology Newman, Peter J Newman, Debra K Arterioscler。Thromb。Vasc。生物23:953 - 64 12775720 Pubmed 2003 血小板内皮细胞粘附molecule-1(压电陶瓷AM-1) inhibits low density lipoprotein-induced signaling in platelets Relou, IA Gorter, G Ferreira, IA van Rijn, HJ Akkerman, Jan Willem N J Biol Chem 278:32638-44 ACTIVATION Reactome Database ID Release 77 9984584 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984584 左吨O-RIGHT PECAM-1 binds PP2A This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PP2A Reactome DB_ID: 9963398 Converted from EntitySet in Reactome PP2A-subunit A Reactome DB_ID: 9963390 PPP2R1A PPP2R1A A0A5F4CGH7 Reactome DB_ID: 9963386 UniProt:A0A5F4CGH7 PPP2R1A UniProt A0A5F4CGH7 2 EQUAL 589 EQUAL Reactome Database ID Release 77 9963386 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963386 Reactome R-CFA-165982 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165982.1 F1PQ04 PPP2R1B PPP2R1B Reactome DB_ID: 9963388 UniProt:F1PQ04 PPP2R1B UniProt F1PQ04 1 EQUAL 601 EQUAL Reactome Database ID Release 77 9963388 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963388 Reactome R-CFA-165980 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165980.1 Reactome Database ID Release 77 9963390 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963390 Reactome R-CFA-165990 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165990.1 1 Converted from EntitySet in Reactome PP2A-catalytic subunit C Reactome DB_ID: 9963396 PPP2CA PPP2CA F1P7I7 Reactome DB_ID: 9963392 UniProt:F1P7I7 PPP2CA UniProt F1P7I7 1 EQUAL 309 EQUAL Reactome Database ID Release 77 9963392 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963392 Reactome R-CFA-165971 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165971.1 PPP2CB PPP2CB F6X958 Reactome DB_ID: 9963394 UniProt:F6X958 PPP2CB UniProt F6X958 1 EQUAL 309 EQUAL Reactome Database ID Release 77 9963394 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963394 Reactome R-CFA-165987 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165987.1 Reactome Database ID Release 77 9963396 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963396 Reactome R-CFA-165977 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-165977.1 1 Converted from EntitySet in Reactome PP2A regulatory subunit B56 Reactome DB_ID: 9963384 F1PMS2 PPP2R5A PPP2R5A Reactome DB_ID: 9963366 UniProt:F1PMS2 PPP2R5A UniProt F1PMS2 1 EQUAL 486 EQUAL Reactome Database ID Release 77 9963366 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963366 Reactome R-CFA-196235 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-196235.1 PPP2R5B PPP2R5B A0A5F4DAC3 Reactome DB_ID: 9963370 UniProt:A0A5F4DAC3 PPP2R5B UniProt A0A5F4DAC3 1 EQUAL 497 EQUAL Reactome Database ID Release 77 9963370 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963370 Reactome R-CFA-535469 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-535469.1 F1P714 PPP2R5D PPP2R5D Reactome DB_ID: 9963374 UniProt:F1P714 PPP2R5D UniProt F1P714 1 EQUAL 602 EQUAL Reactome Database ID Release 77 9963374 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963374 Reactome R-CFA-3008950 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3008950.1 PPP2R5C PPP2R5C A0A5F4BQS3 Reactome DB_ID: 9963378 UniProt:A0A5F4BQS3 PPP2R5C UniProt A0A5F4BQS3 1 EQUAL 524 EQUAL Reactome Database ID Release 77 9963378 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963378 Reactome R-CFA-3008954 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-3008954.1 PPP2R5E PPP2R5E A0A5F4CA12 Reactome DB_ID: 9963382 UniProt:A0A5F4CA12 PPP2R5E UniProt A0A5F4CA12 1 EQUAL 467 EQUAL Reactome Database ID Release 77 9963382 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963382 Reactome R-CFA-1638770 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1638770.1 Reactome Database ID Release 77 9963384 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963384 Reactome R-CFA-196216 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-196216.1 1 Reactome Database ID Release 77 9963398 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9963398 Reactome R-CFA-196206 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-196206.1 p-PECAM:PP2A Reactome DB_ID: 9984221 1 1 Reactome Database ID Release 77 9984221 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984221 Reactome R-CFA-432144 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432144.1 Reactome Database ID Release 77 9984223 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9984223 Reactome R-CFA-432143 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432143.1 PECAM-1 co-immunoprecipitates with PP2A 左吨O-RIGHT Interaction of PECAM-1 and SHP-1 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PTPN6 PTPN6 A0A5F4BS19 Reactome DB_ID: 9973770 UniProt:A0A5F4BS19 PTPN6 UniProt A0A5F4BS19 1 EQUAL 595 EQUAL Reactome Database ID Release 77 9973770 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9973770 Reactome R-CFA-197938 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-197938.1 PECAM-1:SHP-1 complex Reactome DB_ID: 9974002 1 1 Reactome Database ID Release 77 9974002 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9974002 Reactome R-CFA-210221 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-210221.1 Reactome Database ID Release 77 9974004 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9974004 Reactome R-CFA-210277 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-210277.1 The phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain of PECAM-1 is required for the downstream signalling events observed following PECAM-1 ligation. Both SH2 domains of SHP-1 are required in tandem to bind PECAM-1. 9774457 Pubmed 1998 Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. Hua, CT Gamble, JR Vadas, MA Jackson, DE J Biol Chem 273:28332-40 10350061 Pubmed 1999 Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31 Pumphrey, NJ Taylor, V Freeman, S Douglas, MR Bradfield, PF Young, SP Lord, JM Wakelam, MJ Bird, IN Salmon, M Buckley, CD FEBS Lett 450:77-83 左吨O-RIGHT Interaction of PECAM-1 and SHP-2 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp PTPN11 PTPN11 F1Q3J6 Reactome DB_ID: 9967884 UniProt:F1Q3J6 PTPN11 UniProt F1Q3J6 1 EQUAL 597 EQUAL Reactome Database ID Release 77 9967884 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9967884 Reactome R-CFA-162563 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-162563.1 PECAM-1:SHP-2 complex Reactome DB_ID: 9974037 1 1 Reactome Database ID Release 77 9974037 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9974037 Reactome R-CFA-210219 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-210219.1 Reactome Database ID Release 77 9974039 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9974039 Reactome R-CFA-210294 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-210294.1 PECAM-1 becomes tyrosine-phosphorylated during the platelet aggregation process; the phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain is required for downstream signalling events. Phosphorylation creates docking sites for the protein-tyrosine phosphatase SHP-2. The interaction between SHP-2 and PECAM-1 is dependent upon integrin-mediated platelet/platelet interactions and occurs via the Src homology 2 (SH2) domains of the phosphatase and highly conserved phosphatase-binding motifs encompassing phosphotyrosines 663 and 686 within the cytoplasmic domain of PECAM-1. 9054388 Pubmed 1997 The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. Jackson, DE Ward, CM Wang, R Newman, PJ J Biol Chem 272:6986-93 Reactome Database ID Release 77 10045245 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10045245 Reactome R-CFA-432142 1 Reactome稳定的标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-432142.1 Physiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) at Thr180 and Tyr182. The receptor for LDL is ApoER2, a splice variant of the classical ApoE receptor. ApoER2 stimulation leads to association of the Src family kinase Fgr which is probably responsible for subsequent phosphorylation of p38MAPK. This stimulation is transient because LDL also increases the activity of PECAM-1, which stimulates phosphatases that dephosphorylate p38MAPK. 12038793 Pubmed 2002 Platelet activation by the apoB/E receptor-binding domain of LDL Relou, AM Gorter, G van Rijn, HJ Akkerman, Jan Willem N Thromb Haemost 87:880-7