推断是基于豹的同源映射。简而言之，将所有涉及的身体性（进入，输出和催化剂）的反应具有映射的原序/级级蛋黄（用于复合物，至少75％的组分必须具有映射）。还推断出这些事件的高级事件，以便更容易导航。

有关Panther的详细信息另请参阅： PI3K的p85亚基(PIK3R1)与p-ERBB4cyt1同源二聚体的结合 PI3K的p85亚基(PIK3R1)与p-ERBB4cyt1同源二聚体的结合 该事件已从另一种物种中展示的事件计算地推断出来。

推断是基于豹的同源映射。简而言之，将所有涉及的身体性（进入，输出和催化剂）的反应具有映射的原序/级级蛋黄（用于复合物，至少75％的组分必须具有映射）。还推断出这些事件的高级事件，以便更容易导航。

有关Panther的详细信息另请参阅： Reactome DB_ID: 9746268 1 胞质 去 0005829. pik3ca：pik3r1 [cytosol] PIK3CA:PIK3R1 反应DB_ID：9027214 1 UniProt: P42337 Pik3ca Pik3ca Pik3ca 磷脂酰肌醇-3-激酶(PI3K)磷酸化磷脂酰肌醇(PI)及其在肌醇环3位的磷酸化衍生物，产生3-磷酸肌醇。使用ATP和PtdIns(4,5)P2(磷脂酰肌醇4,5-二磷酸)生成磷脂酰肌醇3,4,5-三磷酸(PIP3)。PIP3通过将包含PH结构域的蛋白招募到细胞膜上，包括AKT1和PDPK1，激活涉及细胞生长、存活、增殖、运动和形态的信号级联，发挥着关键作用。参与细胞信号传导以响应各种生长因子。参与受体酪氨酸激酶配体(如EGF、胰岛素、IGF1、VEGFA和PDGF)刺激后AKT1的激活。通过胰岛素受体底物(IRS)蛋白参与信号传导。可能通过调节RhoA活性，在血管发育过程中通过VEGFA信号传导内皮细胞迁移必不可少。淋巴血管发育所需，可能通过与RAS结合和EGF和FGF2的激活，但不通过PDGF。通过PDPK1-AKT1通路调控侵袭性足的形成。通过AKT1途径参与胚胎干细胞的心肌发生。 Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (PubMed:19604150).PATHWAY Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.SUBUNIT Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3) (PubMed:8139567). Interacts with IRS1 in nuclear extracts (PubMed:15197263). Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1 (By similarity). Interacts with HRAS and KRAS (PubMed:17540175). Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (PubMed:17540175). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity).DOMAIN The PI3K-ABD domain and the PI3K-RBD domain interact with the PI3K/PI4K kinase domain. The C2 PI3K-type domain may facilitate the recruitment to the plasma membrane. The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1, and the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N-terminal SH2) region of PIK3R1.DISRUPTION PHENOTYPE Lethal. Embryonic fibroblasts cells are resistant to oncogenic transformation induced by oncogenic receptor tyrosine kinases (RTKs), are unable to differentiate into adipocytes and deficient in cellular signaling in response to various growth factors. Defective responsiveness to insulin led to reduced somatic growth, hyperinsulinemia, glucose intolerance, hyperphagia and increased adiposity.SIMILARITY Belongs to the PI3/PI4-kinase family. 反应 //www.joaskin.com 小家鼠 NCBI分类法 10090 UniProt P42337 链坐标 1 相等的 1068 相等的 反应数据库ID:9736187 1 UniProt: P26450 Pik3r1 Pik3r1 Pik3r1 功能与活化（磷酸化）蛋白-TYR激酶，通过其SH2结构域结合，并用作介于衔接子，介导P110催化单元与质膜的关联。胰岛素敏感组织中葡萄糖摄取和糖原合成的胰岛素刺激的增加所必需的。响应于FGFR1，FGFR2，FGFR3，FGFR4，KITLG / SCF，试剂盒，PDGFRA和PDGFRB，在信号传导中发挥重要作用。同样，在ITGB2信令（按照相似性）中起作用。通过在肝脏代谢过载期间促进XBP1同种型2的XbP1同种型2的核易位来调节对ER应力的细胞反应，因此在葡萄糖耐量改善中发挥作用（PubMed：20348926）.subunit异二聚体监管亚基PIK3R1和P110催化亚基（PIK3CA，PIK3CB或PIK3CD）。用CCDC88A / giV（酪氨酸磷酸化形式）相互作用（通过SH2结构域）;相互作用使得能够募集PIK3R1至EGFR受体，增强PI3K活性和细胞迁移（相似性）。与XBP1同种型2相互作用;相互作用是直接的，并诱导XbP1同种型2的易位在ER应激和/或胰岛素依赖性但与PI3K的依赖性方式中（Pibmed：20348926）中的核心。 Interacts with PIK3R2; the interaction is dissociated in an insulin-dependent manner (PubMed:20348926). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with IRS1 and phosphorylated IRS4. Interacts with NISCH and RUFY3 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR or BCR activation. Interacts with CBLB. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with SOCS7 and HCST. Interacts with AXL, FASLG, FGR, HCK, KIT and BCR. Interacts with PTK2/FAK1 (By similarity). Interacts with PDGFRB (tyrosine phosphorylated) (By similarity). Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:9312046). Interacts with FER. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated) (Probable). Interacts with PDGFRA (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity. Interacts with ERBB4. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (By similarity). Interacts with APPL1 and APPL2 (PubMed:25328665). Interacts with SRC (By similarity). Interacts with ALOX5; this interaction bridges ALOX5 with CD40 after CD40 ligation in B cells and leads to the production of reactive oxygen species (ROS) (By similarity).DOMAIN The SH3 domain mediates the binding to CBLB.PTM Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.PTM Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR (By similarity). Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2.SIMILARITY Belongs to the PI3K p85 subunit family. UniProt P26450 1 相等的 724 相等的 Reactome数据库ID版本77 9746268 数据库标识符。使用此URL将此实例的网页连接到反应组：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=9746268 反应 R-MMU-1806218 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1806218.1 从Reactome中的EntitySet转换而来 反应DB_ID：9778441 1 质膜 去 0005886 p-erbb4cyt1同源过二聚体[血浆膜] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity 反应数据库ID:9778461 1 PI3K:p-ERBB4cyt1[质膜] pi3k：p-erbb4cyt1 Reactome DB_ID: 9746268 1 从Reactome中的EntitySet转换而来 反应DB_ID：9778441 1 Reactome数据库ID版本77 9778461 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9778461 反应 R-MMU-1250373 1 反应稳定标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1250373.1 Reactome数据库ID版本77 9778463 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9778463 反应 R-MMU-1250353 1 反应稳定标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1250353.1 PI3K的p85亚单位（PIK3R1）通过对接ERBB4 JM A CYT1（酪氨酸Y1056）或ERBB4 JM B CYT1（酪氨酸Y1046）亚型上的酪氨酸残基直接与磷酸化ERBB4 CYT1同源二聚体结合（Cohen等人1996，Kainulainen等人2000，Kaushansky等人2008）。 10722704. Pubmed 2000年 一种不激活磷酸肌苷3-激酶的天然ErbB4亚型介导增殖，但不介导生存或趋化 凯努莱宁，V Sundvall，M. Määttä，JA 圣提斯万，E Klagsbrun,迈克尔 Elenius，K 生物化学杂志275:8641-9 18721752 Pubmed 2008 对ErbB4的系统研究显示，19个Tyr磷酸化位点在招募特性上具有不同寻常的选择性 考尚斯基 戈尔斯，答： Budnik,英航 车道,WS 匆匆，j 麦克比思，G 化学生物学15:808-17 8617750. Pubmed 1996 HER4介导NIH 3T3细胞的生物学和生化特性。HER1-HER4异二聚体的证据 科恩，BD 绿色，jm 福伊，L. 下降,惠普 J Biol Chem 271:4813-8 通过电子注释推断 IEA. 去 IEA. 2.7.1.153 PI3K结合p-ERBB4cyt1同源二聚体将PIP2转化为PIP3 PI3K结合p-ERBB4cyt1同源二聚体将PIP2转化为PIP3 该事件已从另一种物种中展示的事件计算地推断出来。

推断是基于豹的同源映射。简而言之，将所有涉及的身体性（进入，输出和催化剂）的反应具有映射的原序/级级蛋黄（用于复合物，至少75％的组分必须具有映射）。还推断出这些事件的高级事件，以便更容易导航。

有关Panther的详细信息另请参阅： 反应数据库ID:113592 1 ATP (4 -) (ChEBI: 30616) ATP（4-） 5'-三磷酸腺苷 atp. atp. ChEBI 30616 Reactome DB_ID: 179856 1 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate (ChEBI: 18348) 1-磷脂酰-1D-肌醇4,5-双磷酸盐 PIP2 ChEBI 18348 Reactome DB_ID: 29370 1 ADP (3 -) (ChEBI: 456216) ADP (3 -) ADP TriaNion. 5&apos-O-[（膦氧基）膦酸]腺苷 ADP. ChEBI 456216 反应数据库ID:179838 1 1-phosphatidyl-1D-myo-inositol 3、4、5-trisphosphate (ChEBI: 16618) 1-磷脂酰-1D-肌醇3,4,5-三磷酸 PIP3 ChEBI 16618 物理体左右 激活 反应数据库ID:9778461 去 0046934. 去分子功能 Reactome数据库ID版本77 9778466 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9778466 Reactome数据库ID版本77 9778468 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9778468 反应 R-MMU-1250370 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1250370.1 活化的PI3K结合磷酸化的ERBB4 CYT-1同源二聚体将PIP2转化为PIP3，导致AKT信号通路的激活(Kainulainen et al. 2000)。 通过电子注释推断 IEA. 去 IEA. Reactome数据库ID版本77 9843351 数据库标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9843351 反应 r - mmu - 1250342 1 反应稳定标识符。使用此URL连接到Reactome中此实例的网页：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1250342.1 ERBB4的CYT1亚型具有一个C-tail酪氨酸残基，该残基在反式自磷酸化后充当PI3K - PIK3R1的p85 α亚基的对接位点(Kaushansky et al. 2008, Cohen et al. 1996)。PIK3R1与ERBB4的CYT1亚型结合后，PI3K的p110催化亚基(PIK3CA)被募集，导致活性PI3K复合物的组装，将PIP2转化为PIP3并激活AKT信号(Kainulainen et al. 2000)。 通过电子注释推断 IEA. 去 IEA.