BioPAX pathway converted from "LTA4 is hydolysed to LTB4 by LTA4H" in the Reactome database. 3.3.2.6 LTA4 is hydolysed to LTB4 by LTA4H LTA4 is hydolysed to LTB4 by LTA4H LTA4 is hydrolyzed to LTB4 This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 265281 1 cytosol GO 0005829 leukotriene A4 [ChEBI:15651] leukotriene A4 Reactome //www.joaskin.com ChEBI 15651 Reactome DB_ID: 29356 1 水(ChEBI: 15377) water ChEBI 15377 Reactome DB_ID: 266056 1 leukotriene B4 [ChEBI:15647] leukotriene B4 ChEBI 15647 PHYSIOL-LEFT-TO-RIGHT 激活 Reactome DB_ID: 9754564 LTA4H:Zn2+ [cytosol] LTA4H:Zn2+ Reactome DB_ID: 9754562 1 UniProt:P24527 Lta4h Mus musculus NCBI Taxonomy 10090 UniProt P24527 Chain Coordinates 2 EQUAL 611 EQUAL Reactome DB_ID: 29426 1 zinc(2+) [ChEBI:29105] zinc(2+) ChEBI 29105 Reactome Database ID Release 77 9754564 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9754564 Reactome R-MMU-266038 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-266038.1 GO 0004463 GO molecular function Reactome Database ID Release 77 9754565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9754565 Reactome Database ID Release 77 9754567 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9754567 Reactome R-MMU-266072 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-266072.1 Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985). 6490615 Pubmed 1984 Leukotriene A4 hydrolase in human leukocytes. Purification and properties Rådmark, O Shimizu, T Jörnvall, H Samuelsson, B J Biol Chem 259:12339-45 2995393 Pubmed 1985 Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes McGee, J Fitzpatrick, F J Biol Chem 260:12832-7 inferred by electronic annotation IEA GO IEA