BioPAX通路从“钙调蛋白结合”在Reactome数据库转换。 钙结合钙调蛋白 钙结合钙调蛋白 当在钙浓度的增加，钙调蛋白（CAM）是通过结合到四个钙离子（克劳奇和克利1980）激活。 撰写：乐Novere，N，Jassal，B，2004-03-31 12时22分05秒 来自：拉什，MG，2008-01-11 00:00:00 编辑：Jassal，Bijay，2008-11-06 反应DB_ID：74016 4. cytosol. 走 0005829 钙（2+）[飞燕：29108] 钙（2+） 反应 http://www.reacectome.org. Chebi. 29108 反应DB_ID：9016707 1 UNIPROT：P0DP23 CALM1 平静1 冷静的 平静1 CAM1. cam FUNCTION钙调蛋白介导了大量的酶，离子通道，水通道蛋白和其他蛋白的通过钙结合控制。中由钙调蛋白 - 钙复合物刺激的酶是一许多蛋白激酶和磷酸酶的。连同CCP110和中心蛋白，参与了遗传途径调节通过胞质分裂中心体循环和进展（PUBMED：16760425）。是电压依赖性L-型钙通道（搜索PubMed：31454269）的调节剂。介导钙依赖性的CACNA1C灭活（PUBMED：26969752）。正调节KCNN2（搜索PubMed：27165696）的钙激活钾通道活性。形成钾通道复合物与KCNQ1和通过钙结合（搜索PubMed：25441029）调节通道的电生理学活性。作为一个传感器，用于调节与由VMP1介导的其它细胞器endomplasmic网接触：ATP2A2（PUBMED：28890335）所需的嗜肺军团菌SidJ。功能（微生物感染）glutamylase activity.SUBUNIT化与MYO1C，MYO5A和RRAD。与MYO10（通过相似性）相互作用。与CEP97，CCP110，TTN /肌联蛋白和SRY相互作用（PUBMED：9804419，PUBMED：12871148，PUBMED：15746192，PUBMED：16760425，PUBMED：17719545）。 Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (PubMed:21167176). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed:23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (PubMed:27564677). Interacts with alpha-synuclein/SNCA (PubMed:23607618). Interacts with SLC9A1 in a calcium-dependent manner (PubMed:30287853). In the absence of Ca(+2), interacts with GIMAP4 (via IQ domain) (By similarity). Interacts with SCN8A; the interaction modulates the inactivation rate of SCN8A (By similarity). Interaction with KIF1A; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with KCNN3 (PubMed:31155282). Interacts with KCNQ1 (via C-terminus); forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner (PubMed:18165683,PubMed:25441029). Interacts with PIK3C3; the interaction modulates PIK3C3 kinase activity (PubMed:28890335).SUBUNIT (Microbial infection) Interacts with Rubella virus protease/methyltransferase p150.SUBUNIT (Microbial infection) Interacts with Legionella pneumophila glutamylase SidJ.DOMAIN The N-terminal and C-terminal lobes of CALM bind to the C-terminus of KCNQ1 in a clamp-like conformation. Binding of CALM C-terminus to KCNQ1 is calcium-independent but is essential for assembly of the structure. Binding of CALM N-terminus to KCNQ1 is calcium-dependent and regulates electrophysiological activity of the channel.PTM Ubiquitination results in a strongly decreased activity.PTM Phosphorylation results in a decreased activity.MISCELLANEOUS This protein has four functional calcium-binding sites.SIMILARITY Belongs to the calmodulin family. HOMO SAPIENS. NCBI分类 9606 UniProt的 p0dp23. 链坐标 2 平等的 149. 平等的 反应DB_ID：74294 1 CALM1：4xCa2 + [胞质溶胶] 平静1：4xca2 + 主动钙调蛋白 反应DB_ID：74016 4. 反应DB_ID：9016707 1 2 平等的 149. 平等的 Reactome数据库ID版本77 74294 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=74294 反应 R-HSA-74294 3. Reactome稳定标识符。使用此URL连接到该实例的网页中Reactome：//www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-74294.3 Reactome数据库ID版本77 74448 数据库标识符。使用此URL连接到该实例的网页中Reactome：//www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=74448 反应 R-HSA-74448 7. Reactome稳定标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-74448.7 7407067 PubMed. 1980年 钙脑钙调平素的阳性合作结合 克劳奇，TH 克利，CB 生物化学19：3692-8