从“CDT1转换的BIoPAX途径从预翻综合复合物中移位。”在反应数据库中。 CDT1从预复制复合物中取代。 CDT1从预复制复合物中取代。 在反应开始时，存在1个分子的“Mcm10:复制前复合物”。在这个反应的最后，有1分子的“Mcm10:活性复制前复合物”和1分子的“CDT1”。

该反应发生在‘细胞核’内。
反应DB_ID：68560 1 核浆 去 0005654 MCM10：预复制复杂[核质] MCM10: pre-replicative复杂 反应DB_ID：68403 1 UniProt: Q7L590 MCM10 MCM10 PRO2249. MCM10 作为复制起始因子，将MCM2-7解旋酶和DNA聚合酶/引物酶复合物聚集在一起，以启动DNA复制。此外，它还能在复制过程中防止DNA损伤。RBBP6和zbtb38介导的调控dna复制和常见脆性位点稳定性的关键效应;作为ZBTB38转录抑制的直接靶点(PubMed:24726359)。子单元自关联(通过相似性)。与ORC2交互。可能与MCM2和MCM6相互作用。与DNA聚合酶α亚基POLA1相互作用。与RECQL4交互;这种交互作用调节RECQL4 unwind活动。与WDHD1交互。DEVELOPMENTAL STAGE Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase.DOMAIN Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.DOMAIN The N-terminal domain mediates homodimerization.SIMILARITY Belongs to the MCM10 family. Reactome //www.joaskin.com 智人 NCBI分类法 9606 uniprot. Q7L590. 链坐标 1 平等的 875 平等的 反应DB_ID：68559 1 pre-replicative复杂(核浆) pre-replicative复杂 PRERC. 反应DB_ID：68558 1 MCM2-7 [核质] MCM2-7 反应DB_ID：68546 1 UNIPROT：P25205 MCM3 MCM3 MCM3 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。需要DNA复制和细胞增殖。MCM2-7复合物的亚单位成分(PubMed:16899510, PubMed:17296731)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:16899510, PubMed:17296731)。与复制特异性DNA聚合酶相关(通过相似性)。与MCMBP交互(PubMed:17296731)。与ANKRD17相互作用(PubMed:23711367)。与MCM3AP亚型MCM3AP相互作用; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).PTM Acetylated by MCM3AP.PTM O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family. uniprot. P25205 2 平等的 808. 平等的 反应DB_ID：68551 1 UniProt: P33992 MCM5 MCM5 CDC46 MCM5 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。MCM2-7复合物的亚单位成分(PubMed:17296731, PubMed:16899510)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:17296731, PubMed:16899510)。与ANKRD17相互作用(PubMed:23711367)。与MCMBP交互(PubMed:17296731)。CMG解旋酶复合物的成分，由MCM2-7复合物、GINS复合物和CDC45(相似度)组成。真核MCM蛋白的早期分离得到多种生物学意义尚不明确的二聚体、三聚体和四聚体配合物。MCM2-7六聚体是一种可能的生理活性复合物。相似性属于MCM家族。 uniprot. P33992 1 平等的 734 平等的 反应DB_ID：68553 1 UNIPROT：Q14566 MCM6 MCM6 MCM6 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。MCM2-7复合物的亚单位成分(PubMed:16899510, PubMed:17296731, PubMed:9305914)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:16899510, PubMed:17296731, PubMed:9305914)。可能与MCM10相互作用(PubMed:11095689)。与TIPIN相互作用(PubMed:17116885)。与CDT1相互作用(PubMed:20202939)。与MCMBP交互(PubMed:17296731)。与DDI2相互作用(PubMed:29290612)。CMG解旋酶复合物的成分，由MCM2-7复合物、GINS复合物和CDC45(相似度)组成。PTM o -糖基化(O-GlcNAcylated)，在细胞周期依赖的方式。POLYMORPHISM Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However, the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence).MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family. uniprot. Q14566 1 平等的 821. 平等的 反应DB_ID：68555 1 UniProt: P33993 MCM7 MCM7 MCM7 CDC47 MCM2 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。需要在紫外线损伤时激活s相检查点。MCM2-7复合物的亚单位成分(PubMed:9305914, PubMed:16899510, PubMed:17296731)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:9305914, PubMed:16899510, PubMed:17296731)。与ATR-ATRIP复合物和RAD17相互作用(PubMed:15210935, PubMed:15538388)。与TIPIN相互作用(PubMed:17116885)。与MCMBP交互(PubMed:17296731)。与ANKRD17相互作用(PubMed:23711367)。 Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).PTM O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.PTM Ubiquitinated by traip when forks converge following formation of DNA interstrand cross-links. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family. uniprot. P33993 2 平等的 719 平等的 反应DB_ID：68549 1 UniProt: P33991 MCM4 MCM4 CDC21 MCM4 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。MCM2-7复合物的亚单位成分(PubMed:16899510, PubMed:9305914)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:16899510, PubMed:9305914)。与MCMBP交互(PubMed:17296731)。CMG解旋酶复合物的成分，由MCM2-7复合物、GINS复合物和CDC45(相似度)组成。天车Sumoylated;SUMO2对蛋白酶体活性抑制引起的应激反应进行修饰(体外)。真核MCM蛋白的早期分离得到多种生物学意义尚不明确的二聚体、三聚体和四聚体配合物。具体来说，MCM467亚复合体具有体外解旋酶活性，该活性被MCM2亚基抑制。MCM2-7六聚体是一种可能的生理活性复合物。相似性属于MCM家族。 uniprot. P33991 2 平等的 863 平等的 反应DB_ID：68557 1 UniProt: P49736 MCM2 MCM2 CDCL1 CCNL1. BM28 MCM2 Kiaa0030 作为MCM2-7复合物(MCM复合物)的组成部分，MCM复合物是真核细胞中“每个细胞周期一次”DNA复制起始和延伸所必需的复制解旋酶。MCM2-7环中的atp酶活性位点是通过两个相邻亚基的相互作用表面形成的，相对于相邻亚基Walker a盒的atp结合位点，保守的精氨酸手指基motif的关键结构以反式形式提供。然而，这六个atp酶活性位点可能对复杂解旋酶活性有不同的贡献。进入S期和细胞分裂所必需的。在耳蜗毛细胞末梢分化发育中发挥作用，并诱导细胞凋亡。MCM2-7复合物的亚单位成分(PubMed:9305914, PubMed:16899510, PubMed:17296731)。该配合物形成一个环状六聚体环，亚基序为mcm2 - mcm4 - mcm4 - mcm7 - mcm3 - mcm5 (PubMed:9305914, PubMed:16899510, PubMed:17296731)。与DBF4相互作用(通过相似性)。与KAT7相互作用(PubMed:16387653)。可能与MCM10相互作用(PubMed:11095689)。replisome complex的组成部分至少由DONSON, MCM2, MCM7, PCNA和TICRR组成(PubMed:28191891)。 Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).PTM Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family. uniprot. P49736 2 平等的 904 平等的 Reactome数据库ID Release 77 68558 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68558 Reactome R-HSA-68558 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-68558.2 反应DB_ID：68544 1 CDT1: cdc 6:兽人:起源复杂(核浆) CDT1: cdc 6:兽人:来源复杂 反应DB_ID：68543 1 cdc 6:兽人:起源复杂(核浆) cdc 6:兽人:来源复杂 反应DB_ID：68542 1 UNIPROT：Q99741 CDC6 CDC6. CDC18L CDC6. 参与DNA复制的起始。也参与检查点控制，确保DNA复制在有丝分裂开始前完成。亚单位与PCNA, ORC1, cyclincdk相互作用(PubMed:9566895)。与HUWE1相互作用(PubMed:17567951)。与ANKRD17相互作用(PubMed:23711367)。与GRWD1交互;GRWD1的起源结合依赖于CDC6 (PubMed:25990725)。与CDT1交互;在染色质上装载MCM复合物时是相互依赖的(PubMed:14672932)。与TTC4相互作用(PubMed:18320024)。属于CDC6/cdc18家族。 uniprot. Q99741 1 平等的 560 平等的 反应DB_ID：68540 1 ORC:复制的起源[核质] 兽人:起源的复制 Reactome DB_ID: 68516 1 UniProt: O43913 ORC5 ORC5 ORC5 ORC5L 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。确定复制起始点的特定DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。ORC的子单元，由至少6个亚单元组成的复合体:ORC1, ORC2, ORC3, ORC4, ORC5和ORC6。ORC受细胞周期依赖性的调节。它在有丝分裂后期的出口处依次组装，进入S期后分解。组织特异性脾、卵巢、前列腺、睾丸和结肠黏膜丰富。OBI1多单泛素化PTM;泛素化是有效激活DNA复制起始位点的重要手段。泛素化水平在有丝分裂和G1期早期细胞中较低，在G1-晚期/ s期早期诱导，在s期达到高峰，在细胞周期结束时降低。属于ORC5家族。 uniprot. O43913 1 平等的 435 平等的 反应DB_ID：68539 1 UNIPROT：Q9Y5N6 ORC6 ORC6 ORC6 ORC6L 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。确定复制起始点的特定DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。不结合组蛋白H3和H4三甲基化标记H3K9ME3，H3K27ME3和H4K20ME3.Subinit组分，由至少6个亚基组成的复合物：ORC1，ORC2，ORC3，ORC4，ORC5和ORC6。ORC受细胞周期依赖性的调节。它在有丝分裂后期的出口处依次组装，进入S期后分解。与DBF4（按照相似性）相互作用。灵活属于ORC6家族。 uniprot. Q9Y5N6. 1 平等的 252. 平等的 反应DB_ID：176970 1 orc2与mcm8 [n核质]相关联 ORC2与MCM8相关联 Reactome DB_ID: 3006646 1 UniProt: Q9UJA3 MCM8 MCM8 C20orf154 MCM8 MCM8-MCM9复合物的功能成分，该复合物通过同源重组(HR)参与修复双链DNA断裂(DBSs)和DNA链间交联(ICLs) (PubMed:23401855)。MRE11-RAD50-NBN/NBS1 (MRN)复合物通过将MRN复合物招募到修复位点并促进复合物核酸酶活性来切除DNA (PubMed:26215093)。可能通过调节MNR复合物的定位，间接调节下游效应因子RAD51对DNA损伤位点(包括DBSs和ICLs)的招募(PubMed:23401855)。MCM8-MCM9复合物对于DNA复制和S期进展是必不可少的(PubMed:23401855)。然而，可能对DNA复制起非必需作用:可能通过将CDC6招募到起源识别复合物(ORC)，参与G(1)阶段前复制复合物(pre-RC)的激活(PubMed:15684404)。可能通过调节HR，在配子发生中起关键作用(通过相似性)。稳定MCM9蛋白(PubMed:23401855, PubMed:26215093)。MCM8-MCM9配合物的亚单位组成，形成由MCM8和MCM9组成的六聚体(PubMed:23401855, PubMed:26300262)。与至少由MSH2, MSH3, MSH6, PMS1和MLH1组成的DNA错配修复(MMR)复合物相互作用(PubMed:26300262)。与RAD51交互; the interaction recruits RAD51 to DNA damage sites (PubMed:23401855). Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1 (PubMed:26215093). Interacts with CDC6 and ORC2 (PubMed:15684404). Interacts with HROB; the interaction recruits the MCM8-MCM9 complex to DNA damage sites (PubMed:31467087).TISSUE SPECIFICITY Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.INDUCTION By E2F1.SIMILARITY Belongs to the MCM family.CAUTION Was initially thought to play a role in DNA replication (PubMed:15684404). However, it was later shown that it is mainly involved in homologous recombination repair (PubMed:23401855). uniprot. Q9UJA3 1 平等的 840 平等的 反应DB_ID：68405 1 UniProt: Q13416 ORC2 ORC2 ORC2L ORC2 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。确定复制起始点的特定DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。结合组蛋白H3和H4三甲基化标记H3K9ME3，H3K20ME3和H4K27ME3。通过保护其免受泛素介导的蛋白质降解来稳定LRWD1。还稳定ORC3.SubUnit组分ORC，由至少6个亚基组成的复合物：ORC1，ORC2，ORC3，ORC4，ORC5和ORC6。ORC受细胞周期依赖性的调节。在有丝分裂后期出口依次组装，进入S期后分解(PubMed:12909626, PubMed:17716973)。与DBF4相互作用(通过相似性)。 Interacts with MCM10 (PubMed:11095689). Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein (PubMed:22645314). Interacts with POLQ (PubMed:24989122).SIMILARITY Belongs to the ORC2 family. uniprot. Q13416 1 平等的 577 平等的 Reactome数据库ID Release 77 176970 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser?db=gk_current&id=176970 Reactome R-HSA-176970 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-176970.1 反应DB_ID：68522 1 UniProt: Q13415 ORC1 ORC1 ORC1 orc1l. PARC1. 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。定义复制起始点的DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。ORC的子单元，由至少6个亚单元组成的复合体:ORC1, ORC2, ORC3, ORC4, ORC5和ORC6。ORC受细胞周期依赖性的调节。它在有丝分裂后期的出口处依次组装，进入S期后分解。与CDC6和KAT7/HBO1相互作用。主要在G1期与LRWD1相互作用，在有丝分裂期间磷酸化后，与LRWD1的亲和性减弱。表达受细胞周期调控，在G1中期开始积累，在G1/S边界达到顶峰，在S期(蛋白水平)下降到基本水平。BAH结构域介导与二甲基化组蛋白H4 ' lys20 ' (H4K20me2)结合，该蛋白在复制起始处富集。PTM在有丝分裂时磷酸化。SIMILARITY Belongs to the ORC1 family. uniprot. Q13415 1 平等的 861 平等的 反应DB_ID：68419 1 复制的起源[核质] 起源的复制 ars. 自主复制序列 起源 Reactome DB_ID: 68513 1 UNIPROT：Q9UBD5 ORC3 ORC3 ORC3 ORC3L 拉塞 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。确定复制起始点的特定DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。结合组蛋白H3和H4三甲基化标记H3K9me3, H3K27me3和H4K20me3。ORC的子单元，由至少6个亚单元组成的复合体:ORC1, ORC2, ORC3, ORC4, ORC5和ORC6。ORC受细胞周期依赖性的调节。它在丝分裂的后的出口处依次组装，并且随着细胞进入S期的拆卸。OBI1多单泛素化PTM;泛素化是有效激活DNA复制起始位点的重要手段。泛素化水平在有丝分裂和G1期早期细胞中较低，在G1-晚期/ s期早期诱导，在s期达到高峰，在细胞周期结束时降低。属于兽人家族。 uniprot. Q9UBD5 1 平等的 711 平等的 Reactome DB_ID: 68519 1 UniProt: O43929 ORC4 ORC4 ORC4 ORC4L 结合复制起始点的起始识别复合物(ORC)的功能成分。ATP-dependent dna结合蛋白。确定复制起始点的特定DNA序列尚未被确定。ORC用于组装启动DNA复制所需的复制前复合物。结合组蛋白H3和H4三甲基化标记H3K9me3, H3K27me3和H4K20me3。ORC的子单元，由至少6个亚单元组成的复合体:ORC1, ORC2, ORC3, ORC4, ORC5和ORC6。ORC受细胞周期依赖性的调节。在有丝分裂后期出口依次组装，进入S期后分解(PubMed:12909626, PubMed:17716973)。与DBF4相互作用(通过相似性)。与POLQ交互(PubMed:24989122)。属于ORC4家族。 uniprot. O43929 1 平等的 436 平等的 Reactome数据库ID Release 77 68540. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68540 Reactome R-HSA-68540 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-68540.2 Reactome数据库ID Release 77 68543 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68543 Reactome R-HSA-68543 1 Reactome稳定的标识符。使用此URL在反垃圾邮件中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa -68543.1 反应DB_ID：68536 1 UniProt: Q9H211 CDT1 CDT1 CDT1 DNA复制和有丝分裂所需的功能(PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564)。DNA复制许可因子，复制前复合物组装所需。在细胞周期G1期与CDC6和起源识别复合物(ORC)合作，促进微染色体维持(MCM)复合物加载到DNA上，生成复制前复合物(pre-RC)(PubMed:14672932)。通过促进稳定的着丝点-微管附着，也需要有丝分裂(PubMed:22581055)。潜在的致癌基因(通过相似性)。亚基与GMNN相互作用;抑制MCM复合物与复制起源的结合(PubMed:11125146, PubMed:14672932, PubMed:14993212, PubMed:15257290)。与cdc 6;在染色质上装载MCM复合物时是相互依赖的(PubMed:14672932)。PCNA相互作用(PubMed:16861906)。G1期和有丝分裂期间与LRWD1相互作用(PubMed:22645314)。 Interacts with NDC80 subunit of the NDC80 complex; leading to kinetochore localization (PubMed:22581055). Interacts with GRWD1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with KAT7 (PubMed:18832067). Interacts with ubiquitin-binding protein FAF1; the interaction is likely to promote CDT1 degradation (PubMed:26842564).DEVELOPMENTAL STAGE Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.INDUCTION Induced by E2F transcription factors (PubMed:14990995).DOMAIN The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.PTM Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37 (PubMed:27296872).PTM Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation.SIMILARITY Belongs to the Cdt1 family. uniprot. Q9H211 1 平等的 546 平等的 Reactome数据库ID Release 77 68544 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68544 Reactome R-HSA-68544 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-68544.1 Reactome数据库ID Release 77 68559. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68559 Reactome R-HSA-68559 1 Reactome稳定的标识符。使用此URL将此实例的网页连接到Reactome中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-68559.1 Reactome数据库ID Release 77 68560 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68560 Reactome R-HSA-68560 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-68560.2 Reactome DB_ID: 156564 1 MCM10:活性复制前复合物[核质] MCM10:主动pre-replicative复杂 Reactome DB_ID: 156562 1 活性预复制复合物[核质] 活跃预复制复合物 反应DB_ID：68543 1 反应DB_ID：68558 1 Reactome数据库ID Release 77 156562 数据库标识符。使用此URL将此实例的网页连接到反应组：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=156562 Reactome R-HSA-156562 1 Reactome稳定的标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-156562.1 反应DB_ID：68403 1 1 平等的 875 平等的 Reactome数据库ID Release 77 156564 数据库标识符。使用此URL将此实例的网页连接到反乐中：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=156564 Reactome R-HSA-156564 2 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-156564.2 反应DB_ID：68536 1 1 平等的 546 平等的 Reactome数据库ID Release 77 68940 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=68940 Reactome r - hsa - 68940 2 Reactome稳定的标识符。使用此URL将此实例的网页连接到Reactome中：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-68940.2 12045100 Pubmed 2002 真核细胞中的DNA复制。 贝尔,SP Dutta，A Annu Rev Biochem 71:333-74