在Reactome数据库中，BioPAX途径由“SMAD7:SMURF1 complex is exported to the cytosol”转换而来。 7 SMAD7：SMURF1复合物出口到细胞溶胶 SMAD7：SMURF1复合物出口到细胞溶胶 Smad7：Smurf1复合物通过Smurf1的C-Terminus中的核导出信号（NES）结合XPO1（CRM1），XPO1使得SMAD7：SMURF1转移到Cytosol（Suzuki等，2002，Tajima等，2003）。在这些实验中使用重组小鼠Smad7和重组人体Smurf1。 作者:Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 综述：黄，涛，2012-05-14 编辑:Jassal, B, 2012-04-10 Reactome DB_ID: 2167923 1 骨髓 走 0005654. SMAD7: SMURF1: XPO1(核浆) SMAD7：SMURF1：XPO1 反应DB_ID：165529 1 UniProt: O14980 XPO1 XPO1. XPO1. CRM1 功能介导具有富亮氨酸核输出信号(NES)的细胞蛋白(货物)和rna的核输出。在细胞核中，与RANBP3结合，协同结合其靶蛋白上的NES和以gtp结合形式活性的gtp酶RAN (RAN - gtp)。该复合物与核孔复合物(NPC)的对接是通过与核孔蛋白结合介导的。核出口复合物进入细胞质后，复合物的分解和Ran-GTP水解为Ran-GDP(分别由RANBP1和RANGAP1诱导)导致出口受体释放货物。核输出的方向性被认为是由Ran在细胞质和细胞核之间的GTP-和gdp结合形式的不对称分布所赋予的。参与U3 snoRNA从卡哈尔体到核仁的转运。结合到带有TMG帽的晚期前体U3 snoRNA。功能(微生物感染)介导从不同病毒(包括HIV-1, HTLV-1和流感a)的细胞核外输出未剪接或不完全剪接的rna。与HIV-1 Rev和HTLV-1 Rex蛋白相互作用并介导细胞核外输出。参与HTLV-1 Rex多化。在一个U snRNA出口复合物中发现的亚单位与PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1和m7g顶RNA(相似)。核输出受体复合物的组成部分，由KPNB1, RAN, SNUPN和XPO1组成。 Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUP42, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502).SUBUNIT (Microbial infection) Interacts with HIV-1 Rev.SUBUNIT (Microbial infection) Interacts with HTLV-1 Rex.SUBUNIT (Microbial infection) Interacts with influenza A nucleoprotein.SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus protein BMLF1.SUBUNIT (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.SUBUNIT (Microbial infection) Interacts with SARS-CoV virus protein ORF9b; this interaction mediates protein ORF9b export out of the nucleus.TISSUE SPECIFICITY Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.MISCELLANEOUS Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.SIMILARITY Belongs to the exportin family. 反应 //www.joaskin.com 智人 NCBI分类法 9606. UniProt O14980 链坐标 1 平等的 1071 平等的 Reactome DB_ID: 2167913 1 Smad7：smurf1 [nocleoplasm] SMAD7：SMURF1. Reactome DB_ID: 3004548 1 UNIPROT：Q9HCE7 SMURF1 SMURF1 KIAA1625 SMURF1 功能E3泛素 - 蛋白质连接酶作为BMP信号通路的负调节剂。介导Smad1和Smad5，2个受体调节的Smads的泛素化和降解，所述BMP途径。促进泛素化和随后的TRAF家族成员和RHOA的蛋白酶体降解。促进泛素化和随后的MAVS蛋白酶体降解（PUBMED：23087404）。在Melanocytes（Pubmed：23999003）中起在树突式形成中发挥作用.Pathway蛋白质改性;蛋白质泛素泛素.Subunit与Traf4相互作用。与FBXL15（通过LRR重复）交互（通过Hect域）。与SMAD7和TGFBR1互动;Smad7募集SMURF1至TGFBR1并调节TGF-β受体降解。与mavs互动; the interaction is mediated by NDFIP1 (PubMed:23087404).TISSUE SPECIFICITY Expressed in melanocytes (PubMed:23999003).DOMAIN The C2 domain mediates membrane localization and substrate selection.PTM Auto-ubiquitinated in presence of NDFIP1 (PubMed:23087404). Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. UniProt Q9HCE7. 1 平等的 757 平等的 Reactome DB_ID: 178197 1 UniProt: O15105 SMAD7 SMAD7 MADH7 Madh8. SMAD7 通过TGF-β（转化生长因子）信号传导的功能拮抗剂1型受体超家族成员;已被证明通过与其受体相关联抑制TGF-β（转化生长因子）和激活素信号传导，从而防止Smad2接入。用作适配器募集SMURF2到TGF-Beta受体复合物。还通过募集到TGFBR1的PPP1R15A-PP1复合物，促进其去磷酸化。通过从14-3-3蛋白YWHAQ刺激其作为负调节剂的解离来呈正常调节PDPK1激酶活性。津是与WWP1（相似性）相互作用。与COPS5互动。与NEDD4L互动。与stambp互动。与RNF111，AXIN1和AXIN2交互。与PPP1R15A交互。 Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with PDPK1 (via PH domain).TISSUE SPECIFICITY Ubiquitous with higher expression in the lung and vascular endothelium.INDUCTION By TGFB1.PTM Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.PTM Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019, PubMed:16601693). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (PubMed:11278251).PTM Acetylation prevents ubiquitination and degradation mediated by SMURF1.SIMILARITY Belongs to the dwarfin/SMAD family. UniProt O15105. 1 平等的 426. 平等的 反应数据库ID版本77 2167913. 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2167913 反应 r - hsa - 2167913 1 Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2167913.1 反应数据库ID版本77 2167923 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=2167923 反应 r - hsa - 2167923 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-2167923.1 反应DB_ID：165539 1 胞质 走 0005829. 1 平等的 1071 平等的 Reactome DB_ID: 2167927 1 SMAD7: SMURF1(胞质) SMAD7：SMURF1. Reactome DB_ID: 173478 1 1 平等的 426. 平等的 Reactome DB_ID: 975972 1 1 平等的 757 平等的 反应数据库ID版本77 2167927 数据库标识符。使用此URL在反垃圾中连接到此实例的网页：http：//www.reagome.org/cgi-bin/eventbrowser?db=gk_current&id=2167927 反应 r - hsa - 2167927 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-2167927.1 物理体左右 激活 Reactome DB_ID: 2167923 走 0005215 去分子功能 反应数据库ID版本77 178174 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacectome.org/cgi-bin/eventbrowser?db=gk_current&id=178174 反应数据库ID版本77 178215 数据库标识符。使用此URL在反弹中连接到此实例的网页：http：//www.reacontome.org/cgi-bin/eventbrowser?db=gk_current&id=178215 反应 r - hsa - 178215 1 Reactome稳定的标识符。使用此URL将此实例的Web页面连接到Reactome：http：//www.reacontome.org/cgi-bin/eventbrowser_st_id?st_id=r-hsa-178215.1 12151385. PubMed. 2002年 Smurf1通过将Smad7靶向于质膜来调控Smad7的抑制活性 铃木，C. Murakami，G. Fukuchi，M. Shimanuki T Shikauchi Y 导演今村昌平T Miyazono K J Biol Chem 277:39919-25 12519765 PubMed. 2003年 Smad泛素调节因子1 (Smurf1)依赖于染色体区域维持1 (CRM1)的核输出，是Smad7对转化生长因子- β信号的负调控所必需的 日本田岛,Y Goto K 吉田,M Shinomiya，K Sekimoto T Yoneda Y Miyazono K 导演今村昌平T J Biol Chem 278：10716-21