bioax途径由Reactome数据库中的“PDGFR磷酸化PLCgamma”转化而来。

2.7.10

PDGFR磷酸化PLCgamma

激活的PDGF受体磷酸化PLCgamma上的酪氨酸残基472,771,783和1254，激活酶。

作者:Rothfels, K, 2011-08-24 评论:Heldin, CH, 2008-11-23 19:29:34

Reactome DB_ID: 186795

等离子体膜去 0005886 PDGF:Phospho-PDGF受体二聚体:PLC-gamma[质膜]

PDGF: Phospho-PDGF受体二聚体:PLC-gamma

Reactome DB_ID: 186811

PDGF:Phospho-PDGF受体二聚体[质膜]

PDGF: Phospho-PDGF受体二聚体

从Reactome中的EntitySet转换而来

Reactome DB_ID: 380760

细胞外区域去 0005576

活性PDGF二聚体(AA, AB, BB)[细胞外区域] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity Reactome //www.joaskin.com 从Reactome中的EntitySet转换而来

Reactome DB_ID: 186821

磷酸- PDGF受体二聚体[质膜] 从Reactome中的EntitySet转换而来。每个同义词是一个PhysicalEntity的名称，每个XREF指向一个PhysicalEntity 智人

NCBI分类法 9606 Reactome数据库ID Release 77 186811 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186811 Reactome r - hsa - 186811

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186811.1

Reactome DB_ID: 167682

UniProt: P19174 PLCG1

PLCG1

PLCG1 PLC1 介导第二信使分子甘油二酯(DAG)和肌醇1,4,5-三磷酸(IP3)的产生。在细胞内信号级联调节中起重要作用。随着配体介导的受体型酪氨酸激酶的激活而被激活，如PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3和FGFR4(相似)。在肌动蛋白重组和细胞迁移中发挥作用(PubMed:17229814)。活性调节由酪氨酸残基磷酸化激活。亚单元通过其SH3结构域与AGAP2相互作用。与RET相互作用(通过SH2结构域)，与FLT1(酪氨酸磷酸化)相互作用(通过相似性)。(通过SH2结构域)与FGFR1、FGFR2、FGFR3和FGFR4相互作用(磷酸化)。TCR激活时与LAT(磷酸化)相互作用。(通过SH3结构域)与TNK1的Pro-rich结构域相互作用。与BLNK, VAV1, GRB2和NCK1以b细胞抗原受体依赖的方式相关。与活化的t细胞中的CBLB相互作用; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome.SUBUNIT (Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.DOMAIN The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1 (PubMed:10747847).PTM Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.PTM Ubiquitinated by CBLB in activated T-cells. UniProt P19174

链坐标

平等的

1290

平等的

Reactome数据库ID Release 77 186795 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=186795 Reactome r - hsa - 186795

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-186795.2

Reactome DB_ID: 113592

胞质去 0005829

ATP (4 -) (ChEBI: 30616)

ATP (4)

腺苷5 '三磷酸三磷酸腺苷三磷酸腺苷 ChEBI 30616

Reactome DB_ID: 29370

ADP (3 -) (ChEBI: 456216)

ADP (3 -)

ADP trianion 事情就让它5,- o - [(phosphonatooxy) phosphinato]腺苷 ADP ChEBI 456216

Reactome DB_ID: 1524184

PDGF:p-PDGFR二聚体:p-PLCgamma[质膜]

PDGF: p-PDGFR二聚体:p-PLCgamma

Reactome DB_ID: 186811

Reactome DB_ID: 167679

O4 -phospho-L-tyrosine 472

472

平等的

O4的-phospho-L-tyrosine (MOD: 00048)

O4 -phospho-L-tyrosine 771

771

平等的

O4 -phospho-L-tyrosine 783

783

平等的

O4 -phospho-L-tyrosine 1253

1253

平等的

1290

平等的

Reactome数据库ID Release 77 1524184 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=1524184 Reactome r - hsa - 1524184

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1524184.1 PHYSIOL-LEFT-TO-RIGHT

激活

Reactome DB_ID: 186795 去 0004713

去分子功能

Reactome数据库ID Release 77 1524188 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=1524188 Reactome数据库ID Release 77 1524186 数据库标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=1524186 Reactome r - hsa - 1524186

Reactome稳定的标识符。使用此URL连接到Reactome中的此实例的网页://www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1524186.2 2472219 Pubmed 1989 磷脂酶C-gamma是PDGF和EGF受体蛋白酪氨酸激酶在体内和体外的底物 Meisenhelder J Suh, PG Rhee, SG 猎人,托尼细胞57:1109-22 10579907 Pubmed 1999 作为信号转导元件的磷脂酶c 木匠,克霁,问 Exp Cell Res 253:15-24