BioPAX pathway converted from "Translocation of tBID to mitochondria" in the Reactome database. Translocation of tBID to mitochondria Translocation of tBID to mitochondria N-myristoylation targets tBID to the mitochondrial outer membrane (Zha et al. 2000). Reactome DB_ID: 141373 1 cytosol GO 0005829 UniProt:P55957 BID BID BID FUNCTION The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.SUBUNIT Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH (PubMed:20392206). Interacts with PLEKHN1 (PubMed:29531808).TISSUE SPECIFICITY Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).DOMAIN Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.PTM TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.PTM p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. Reactome //www.joaskin.com Homo sapiens NCBI分类法 9606 UniProt P55957 myristoylated残留at unknown position myristoylated残留[MOD:00438] Chain Coordinates 62 EQUAL 195 EQUAL Reactome DB_ID: 114266 1 mitochondrial outer membrane GO 0005741 myristoylated残留at unknown position 62 EQUAL 195 EQUAL Reactome Database ID Release 77 139920 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=139920 Reactome R-HSA-139920 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-139920.2 11099414 Pubmed 2000 Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis Zha, J Weiler, S Oh, KJ Wei, MC Korsmeyer, SJ Science 290:1761-5