The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 10389407 1 nucleoplasm GO 0005654 TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC Reactome DB_ID: 10330046 1 ERCC1:ERCC4 [nucleoplasm] ERCC1:ERCC4 Reactome DB_ID: 10330044 1 UniProt:A0A6I8Q7G3 ercc4 Reactome //www.joaskin.com Xenopus tropicalis NCBI Taxonomy 8364 UniProt A0A6I8Q7G3 Chain Coordinates 1 EQUAL 916 EQUAL Reactome DB_ID: 10330040 1 UniProt:A0A6I8Q4D8 ercc1 UniProt A0A6I8Q4D8 1 EQUAL 297 EQUAL Reactome Database ID Release 77 10330046 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10330046 Reactome R-XTR-109943 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109943.1 Reactome DB_ID: 10330754 1 UniProt:F6ZE78 plscr4 UniProt F6ZE78 1 EQUAL 301 EQUAL Reactome DB_ID: 10389330 1 UniProt:A0A6I8QDB0 hmgn1 UniProt A0A6I8QDB0 2 EQUAL 100 EQUAL Reactome DB_ID: 10389288 1 Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) Reactome DB_ID: 10326496 1 Ghost homologue of POLR2H [nucleoplasm] Ghost homologue of POLR2H Reactome DB_ID: 10326478 1 UniProt:A0A6I8QYT9 polr2i UniProt A0A6I8QYT9 1 EQUAL 125 EQUAL Reactome DB_ID: 10326486 1 UniProt:B3DL15 polr2d UniProt B3DL15 1 EQUAL 142 EQUAL Reactome DB_ID: 10326508 1 UniProt:Q6DDA6 polr2f UniProt Q6DDA6 2 EQUAL 127 EQUAL Reactome DB_ID: 10326490 1 UniProt:Q28G24 polr2g UniProt Q28G24 1 EQUAL 172 EQUAL Reactome DB_ID: 10326482 1 UniProt:F6QHD9 polr2b UniProt F6QHD9 1 EQUAL 1174 EQUAL Reactome DB_ID: 10326504 1 UniProt:Q28HF5 polr2e UniProt Q28HF5 1 EQUAL 210 EQUAL Reactome DB_ID: 10389286 1 UniProt:A0A6I8R7L6 polr2a UniProt A0A6I8R7L6 O-phospho-L-serine at 5 (in Homo sapiens) 5 EQUAL O-phospho-L-serine [MOD:00046] O-phospho-L-serine at 2 (in Homo sapiens) 2 EQUAL ubiquitinylated lysine at unknown position ubiquitinylated lysine [MOD:01148] 1 EQUAL 1970 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10325155 1 Ub [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity ubc [nucleoplasm] mrpl3 [nucleoplasm] UniProt A0A6I8RD22 UniProt Q28I48 Reactome DB_ID: 10326500 1 UniProt:A0A6I8T054 polr2k UniProt A0A6I8T054 1 EQUAL 58 EQUAL Reactome DB_ID: 10326494 1 UniProt:Q6P7Y7 polr2c UniProt Q6P7Y7 2 EQUAL 275 EQUAL Reactome DB_ID: 10326474 1 Ghost homologue of POLR2J [nucleoplasm] Ghost homologue of POLR2J Reactome DB_ID: 10326512 1 UniProt:Q1ECU1 polr2l.2 UniProt Q1ECU1 1 EQUAL 67 EQUAL Reactome Database ID Release 77 10389288 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389288 Reactome R-XTR-6781851 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6781851.1 Reactome DB_ID: 10380597 1 UniProt:A0A6I8S1G0 ercc6 UniProt A0A6I8S1G0 1 EQUAL 1493 EQUAL Reactome DB_ID: 10389326 1 XAB2 complex [nucleoplasm] XAB2 complex Reactome DB_ID: 10327011 1 UniProt:A0A6I8SW61 aqr UniProt A0A6I8SW61 1 EQUAL 1485 EQUAL Reactome DB_ID: 10326885 1 Ghost homologue of PRPF19 [nucleoplasm] Ghost homologue of PRPF19 Reactome DB_ID: 10389324 1 UniProt:Q6DJ13 znf830 UniProt Q6DJ13 2 EQUAL 372 EQUAL Reactome DB_ID: 10327019 1 Ghost homologue of ISY1 [nucleoplasm] Ghost homologue of ISY1 Reactome DB_ID: 10327023 1 UniProt:A0A6I8QFG6 LOC100496569 UniProt A0A6I8QFG6 1 EQUAL 301 EQUAL Reactome DB_ID: 10327037 1 UniProt:F6X8R5 xab2 UniProt F6X8R5 1 EQUAL 855 EQUAL Reactome Database ID Release 77 10389326 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389326 Reactome R-XTR-6781957 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6781957.1 Reactome DB_ID: 10386931 1 UniProt:F7AA61 xpa UniProt F7AA61 2 EQUAL 273 EQUAL Reactome DB_ID: 10389277 1 ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] ERCC8:DDB1:CUL4:RBX1 Converted from EntitySet in Reactome Reactome DB_ID: 10383616 1 CUL4 [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity cul4a [nucleoplasm] cul4b [nucleoplasm] UniProt F7D2D5 UniProt L7N2Q8 Reactome DB_ID: 10361451 1 UniProt:A0A6I8S0I4 rbx1 UniProt A0A6I8S0I4 2 EQUAL 108 EQUAL Reactome DB_ID: 10383620 1 UniProt:A0A6I8RMP9 ddb1 UniProt A0A6I8RMP9 1 EQUAL 1140 EQUAL Reactome DB_ID: 10389275 1 UniProt:Q0V9H6 ercc8 UniProt Q0V9H6 1 EQUAL 396 EQUAL Reactome Database ID Release 77 10389277 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389277 Reactome R-XTR-6781841 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6781841.1 Reactome DB_ID: 10353812 1 UniProt:F7DX95 ep300 UniProt F7DX95 2 EQUAL 2414 EQUAL Reactome DB_ID: 10389320 1 UVSSA:USP7 [nucleoplasm] UVSSA:USP7 Reactome DB_ID: 10374776 1 UniProt:A0A6I8SYE2 usp7 UniProt A0A6I8SYE2 1 EQUAL 1102 EQUAL Reactome DB_ID: 10389318 1 UniProt:F7AEX0 uvssa UniProt F7AEX0 1 EQUAL 709 EQUAL Reactome Database ID Release 77 10389320 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389320 Reactome R-XTR-6781845 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6781845.1 Reactome DB_ID: 6782202 1 5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] 5'-incised damaged DNA:trimmed nascent mRNA Reactome DB_ID: 10389398 1 (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC Reactome DB_ID: 10330244 1 RPA heterotrimer [nucleoplasm] RPA heterotrimer Reactome DB_ID: 10325088 1 UniProt:Q6DFS2 rpa2 UniProt Q6DFS2 1 EQUAL 270 EQUAL Reactome DB_ID: 10325080 1 UniProt:Q5FW17 rpa1 UniProt Q5FW17 2 EQUAL 616 EQUAL Reactome DB_ID: 10325082 1 Ghost homologue of RPA3 [nucleoplasm] Ghost homologue of RPA3 Reactome Database ID Release 77 10330244 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10330244 Reactome R-XTR-68462 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68462.1 Reactome DB_ID: 10325290 1 RFC Heteropentamer[nucleoplasm] RFC Heteropentamer Reactome DB_ID: 10325280 1 UniProt:F7ANQ6 rfc3 UniProt F7ANQ6 1 EQUAL 356 EQUAL Reactome DB_ID: 10325284 1 UniProt:F6V7X9 rfc2 UniProt F6V7X9 1 EQUAL 354 EQUAL Reactome DB_ID: 10325276 1 UniProt:Q28GP1 rfc4 UniProt Q28GP1 1 EQUAL 363 EQUAL Reactome DB_ID: 10325272 1 UniProt:A0A6I8SM21 rfc5 UniProt A0A6I8SM21 1 EQUAL 340 EQUAL Reactome DB_ID: 10325288 1 UniProt:F7C9M5 rfc1 UniProt F7C9M5 1 EQUAL 1148 EQUAL Reactome Database ID Release 77 10325290 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10325290 Reactome R-XTR-68436 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-68436.1 Reactome DB_ID: 10389396 1 Ghost homologue of (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] Ghost homologue of (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) Reactome Database ID Release 77 10389398 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389398 Reactome R-XTR-6790530 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6790530.1 Reactome DB_ID: 10386899 1 UniProt:F6RTJ3 ercc5 UniProt F6RTJ3 1 EQUAL 1186 EQUAL Reactome DB_ID: 10330828 1 TFIIH [nucleoplasm] TFIIH Reactome DB_ID: 10330812 1 Ghost homologue of GTF2H3 [nucleoplasm] Ghost homologue of GTF2H3 Reactome DB_ID: 10330806 1 Ghost homologue of ERCC2 [nucleoplasm] Ghost homologue of ERCC2 Reactome DB_ID: 10330804 1 CAK [nucleoplasm] CAK Reactome DB_ID: 10330802 1 UniProt:A0A7D9NM68 cntrl UniProt A0A7D9NM68 1 EQUAL 309 EQUAL Reactome DB_ID: 10330794 1 Ghost homologue of CDK7 [nucleoplasm] Ghost homologue of CDK7 Reactome DB_ID: 10330798 1 UniProt:Q28FV7 ccnh UniProt Q28FV7 1 EQUAL 323 EQUAL Reactome Database ID Release 77 10330804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10330804 Reactome R-XTR-69221 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-69221.1 Reactome DB_ID: 10330816 1 UniProt:A0A6I8PUD2 gtf2h2 UniProt A0A6I8PUD2 1 EQUAL 395 EQUAL Reactome DB_ID: 10330826 1 Ghost homologue of GTF2H5 [nucleoplasm] Ghost homologue of GTF2H5 Reactome DB_ID: 10330824 1 UniProt:A0A6I8RYY6 gtf2h1 UniProt A0A6I8RYY6 1 EQUAL 548 EQUAL Reactome DB_ID: 10330810 1 UniProt:F6UIE1 ercc3 UniProt F6UIE1 1 EQUAL 782 EQUAL Reactome DB_ID: 10330820 1 UniProt:A0A6I8PUZ2 gtf2h4 UniProt A0A6I8PUZ2 1 EQUAL 462 EQUAL Reactome Database ID Release 77 10330828 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10330828 Reactome R-XTR-109634 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-109634.1 Reactome Database ID Release 77 10389407 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389407 Reactome R-XTR-6782219 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6782219.1 Reactome DB_ID: 10330046 1 Reactome DB_ID: 10386899 1 1 EQUAL 1186 EQUAL Reactome DB_ID: 10389400 1 TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC Reactome DB_ID: 10330754 1 1 EQUAL 301 EQUAL Reactome DB_ID: 10389277 1 Reactome DB_ID: 10353812 1 2 EQUAL 2414 EQUAL Reactome DB_ID: 10389320 1 Reactome DB_ID: 6782213 1 incised DNA without lesion:trimmed nascent mRNA [nucleoplasm] incised DNA without lesion:trimmed nascent mRNA Reactome DB_ID: 10389330 1 2 EQUAL 100 EQUAL Reactome DB_ID: 10389398 1 Reactome DB_ID: 10330828 1 Reactome DB_ID: 10389288 1 Reactome DB_ID: 10380597 1 1 EQUAL 1493 EQUAL Reactome DB_ID: 10389326 1 Reactome Database ID Release 77 10389400 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389400 Reactome R-XTR-6782222 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6782222.1 Reactome DB_ID: 10386931 1 2 EQUAL 273 EQUAL PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10389407 GO 0004520 GO molecular function Reactome Database ID Release 77 10389408 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389408 Reactome Database ID Release 77 10389410 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10389410 Reactome R-XTR-6782224 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-6782224.1 In transcription-coupled nucleotide excision repair (TC-NER), as well as in global genome nucleotide excision repair (GG-NER), the cleavage of the damaged DNA strand 3' to the site of damage is carried out by a DNA endonuclease XPG (ERCC5). While the NER-mediated DNA synthesis may be initiated prior to the 3' incision (Staresincic et al. 2009), the components of the incision complex probably dissociate from the NER site shortly after the DNA synthesis complex assembly and 3' incision (Overmeer et al. 2011). The exception is the RPA heterotrimer, which is a constituent of the NER post-incision complex, and also coats the undamaged DNA strand, thereby protecting it from endonucleolytic cleavage. RNA polymerase II-associated factors also remain bound to the TC-NER site. 21282463 Pubmed 2011 Replication protein A safeguards genome integrity by controlling NER incision events Overmeer, René M Moser, Jill Volker, Marcel Kool, Hanneke Tomkinson, Alan E van Zeeland, Albert A Mullenders, Leon H F Fousteri, Maria J. Cell Biol. 192:401-15 19279666 Pubmed 2009 Coordination of dual incision and repair synthesis in human nucleotide excision repair Staresincic, Lidija Fagbemi, Adebanke F Enzlin, Jacqueline H Gourdin, Audrey M Wijgers, Nils Dunand-Sauthier, Isabelle Giglia-Mari, Giuseppina Clarkson, Stuart G Vermeulen, Wim Schärer, Orlando D EMBO J. 28:1111-20 inferred by electronic annotation IEA GO IEA