The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 10381773 1 extracellular region GO 0005576 UniProt:A0A6I8RJK8 nppa Reactome //www.joaskin.com Xenopus tropicalis NCBI Taxonomy 8364 UniProt A0A6I8RJK8 Chain Coordinates 1 EQUAL 153 EQUAL Reactome DB_ID: 10381777 1 26 EQUAL 55 EQUAL Reactome DB_ID: 10381775 1 1 EQUAL 25 EQUAL Reactome DB_ID: 10381779 1 56 EQUAL 123 EQUAL Reactome DB_ID: 10381781 1 124 EQUAL 151 EQUAL PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10381785 plasma membrane GO 0005886 UniProt:A0A6I8S8A6 corin UniProt A0A6I8S8A6 802 EQUAL 1042 EQUAL GO 0004252 GO molecular function Reactome Database ID Release 77 10381786 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10381786 Reactome Database ID Release 77 10381788 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10381788 Reactome R-XTR-5578783 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-XTR-5578783.1 Atrial natriuretic factor (NPPA(124-151) aka ANF) is a cardiac hormone essential for the regulation of blood pressure and promoting natriuresis, diuresis and vasodilation. In cardiac myocytes, NPPA is synthesised as an inactive precursor, pro-NPPA, that is converted to the biologically-active form by cleavage. Atrial natriuretic peptide-converting enzyme (CORIN) is the serine-type endopeptidase involved in NPPA processing. It is itself cleaved into 5 chains, with CORIN(802-1042) being the activated protease fragment (Yan et al. 2000, Knappe et al. 2003, Liao et al. 2007). 10880574 Pubmed 2000 Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme Yan, W Wu, F Morser, J Wu, Q Proc. Natl. Acad. Sci. U.S.A. 97:8525-9 14559895 Pubmed 2003 Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin Knappe, Sabine Wu, Faye Masikat, Mary Rose Morser, John Wu, Qingyu J. Biol. Chem. 278:52363-70 17660514 Pubmed 2007 Role of glycosylation in corin zymogen activation Liao, Xudong Wang, Wei Chen, Shenghan Wu, Qingyu J. Biol. Chem. 282:27728-35 inferred by electronic annotation IEA GO IEA