The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 113592 2 cytosol GO 0005829 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome //www.joaskin.com ChEBI 30616 Reactome DB_ID: 10213056 1 p-2S-MAP2K1:MAPK3 [cytosol] p-2S-MAP2K1:MAPK3 Reactome DB_ID: 10213052 1 UniProt:A5WWB4 map2k1 Danio rerio NCBI Taxonomy 7955 UniProt A5WWB4 O-phospho-L-serine at 218 (in Homo sapiens) 218 EQUAL O-phospho-L-serine [MOD:00046] O-phospho-L-serine at 222 (in Homo sapiens) 222 EQUAL Chain Coordinates 2 EQUAL 393 EQUAL Reactome DB_ID: 10213054 1 UniProt:Q7ZVK8 mapk3 UniProt Q7ZVK8 2 EQUAL 379 EQUAL Reactome Database ID Release 77 10213056 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10213056 Reactome R-DRE-109838 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109838.1 Reactome DB_ID: 10213139 1 p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol] p-T,Y-MAPK3:p-2S-MAP2K1 Reactome DB_ID: 10213052 1 O-phospho-L-serine at 218 (in Homo sapiens) 218 EQUAL O-phospho-L-serine at 222 (in Homo sapiens) 222 EQUAL 2 EQUAL 393 EQUAL Reactome DB_ID: 10213137 1 O-phospho-L-threonine at 202 (in Homo sapiens) 202 EQUAL O-phospho-L-threonine [MOD:00047] O4'-phospho-L-tyrosine at 204 (in Homo sapiens) 204 EQUAL O4'-phospho-L-tyrosine [MOD:00048] 2 EQUAL 379 EQUAL Reactome Database ID Release 77 10213139 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10213139 Reactome R-DRE-109843 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109843.1 Reactome DB_ID: 29370 2 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10213056 GO 0004674 GO molecular function Reactome Database ID Release 77 10213140 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10213140 Reactome Database ID Release 77 10213148 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10213148 Reactome R-DRE-109860 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-DRE-109860.1 MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop. 23954936 Pubmed 2013 Mitogen-activated protein kinases in innate immunity Arthur, J Simon C Ley, Steven C Nat. Rev. Immunol. 13:679-92 22177953 Pubmed 2012 MEK1/2 dual-specificity protein kinases: structure and regulation Roskoski, Robert Jr Biochem. Biophys. Res. Commun. 417:5-10 8131746 Pubmed 1994 Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues Zheng, CF Guan, KL EMBO J 13:1123-31 8388392 Pubmed 1993 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Zheng, CF Guan, KL J Biol Chem 268:11435-9 inferred by electronic annotation IEA GO IEA INHIBITION Reactome Database ID Release 77 10213149 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10213149 Reactome DB_ID: 10213144 O-phospho-L-serine at 218 (in Homo sapiens) 218 EQUAL O-phospho-L-serine at 222 (in Homo sapiens) 222 EQUAL O-phospho-L-threonine at 286 (in Homo sapiens) 286 EQUAL O-phospho-L-threonine at 292 (in Homo sapiens) 292 EQUAL 2 EQUAL 393 EQUAL