The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 10038438 1 plasma membrane GO 0005886 PIP3:BTK:G-protein beta-gamma complex [plasma membrane] PIP3:BTK:G-protein beta-gamma complex Reactome DB_ID: 179838 1 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate PIP3 Reactome //www.joaskin.com ChEBI 16618 Reactome DB_ID: 9962221 1 G-protein beta-gamma complex [plasma membrane] G-protein beta-gamma complex Converted from EntitySet in Reactome Reactome DB_ID: 9962197 1 G-protein gamma subunit [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity GNG2 [plasma membrane] Canis familiaris NCBI Taxonomy 9615 UniProt J9PAK7 Converted from EntitySet in Reactome Reactome DB_ID: 9962219 1 cytosol GO 0005829 G-protein beta subunit [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity GNB1 [cytosol] UniProt P62872 Reactome Database ID Release 77 9962221 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9962221 Reactome R-CFA-167434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-167434.1 Reactome DB_ID: 10003709 1 UniProt:A0A5F4BPN2 BTK UniProt A0A5F4BPN2 Chain Coordinates 2 EQUAL 659 EQUAL Reactome Database ID Release 77 10038438 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10038438 Reactome R-CFA-8964249 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8964249.1 Reactome DB_ID: 10038438 1 Reactome Database ID Release 77 10038458 Database identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10038458 Reactome R-CFA-8964271 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-8964271.1 g蛋白耦合extracell受体(GPCR)意义ular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. In the membrane, the G-protein beta-gamma complex binds to the catalytic domain of BTK and activates it. Active BTK is then released to the cytoplasm. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling. 11742120 Pubmed 2002 Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Laederach, Alain Cradic, Kendall W Brazin, Kristine N Zamoon, Jamillah Fulton, D Bruce Huang, Xin-Yun Andreotti, Amy H Protein Sci. 11:36-45 7567982 Pubmed 1995 Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits Langhans-Rajasekaran, S A Wan, Y Huang, X Y Proc. Natl. Acad. Sci. U.S.A. 92:8601-5 11698416 Pubmed 2002 G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase Lowry, William E Huang, Xin-Yun J. Biol. Chem. 277:1488-92 inferred by electronic annotation IEA GO IEA