The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp Reactome DB_ID: 10022853 1 nucleoplasm GO 0005654 ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome Reactome DB_ID: 10022851 1 ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] ERCC8:DDB1:CUL4:RBX1 Converted from EntitySet in Reactome Reactome DB_ID: 10016415 1 CUL4 [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity CUL4A [nucleoplasm] CUL4B [nucleoplasm] Reactome //www.joaskin.com Canis familiaris NCBI Taxonomy 9615 UniProt F1Q284 UniProt A0A5F4CGL9 Reactome DB_ID: 10016419 1 UniProt: E2R9E3 DDB1 UniProt E2R9E3 Chain Coordinates 1 EQUAL 1140 EQUAL Reactome DB_ID: 10022849 1 UniProt:A0A5F4CPP7 ERCC8 UniProt A0A5F4CPP7 1 EQUAL 396 EQUAL Reactome DB_ID: 9954902 1 UniProt:A0A5F4CBX7 RBX1 UniProt A0A5F4CBX7 2 EQUAL 108 EQUAL Reactome Database ID Release 77 10022851 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022851 Reactome R-CFA-6781841 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781841.1 Reactome DB_ID: 10021011 1 COP9 signalosome [nucleoplasm] COP9 signalosome Reactome DB_ID: 10020975 1 UniProt:A0A5F4C4T3 COPS2 UniProt A0A5F4C4T3 1 EQUAL 443 EQUAL Reactome DB_ID: 10020991 1 UniProt:F1PG59 COPS6 UniProt F1PG59 1 EQUAL 327 EQUAL Reactome DB_ID: 10020979 1 UniProt: E2RD70 COPS3 UniProt E2RD70 2 EQUAL 423 EQUAL Reactome DB_ID: 10020995 1 UniProt:J9NYE0 COPS8 UniProt J9NYE0 2 EQUAL 209 EQUAL Reactome DB_ID: 10020999 1 UniProt:F1P996 GPS1 UniProt F1P996 2 EQUAL 491 EQUAL Reactome DB_ID: 10020987 1 UniProt: E2QWE0 COPS5 UniProt E2QWE0 2 EQUAL 334 EQUAL Reactome DB_ID: 10020983 1 UniProt: E2RT55 COPS4 UniProt E2RT55 2 EQUAL 406 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10021009 1 COPS7 [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity COPS7B [nucleoplasm] COPS7A [nucleoplasm] UniProt A0A5F4D732 UniProt E2RED3 Reactome Database ID Release 77 10021011 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10021011 Reactome R-CFA-5697024 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5697024.1 Reactome Database ID Release 77 10022853 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022853 Reactome R-CFA-6781842 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781842.1 Reactome DB_ID: 10022845 1 Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 Reactome DB_ID: 9958719 1 UniProt: E2QSK6 ERCC6 UniProt E2QSK6 1 EQUAL 1493 EQUAL Reactome DB_ID: 10022840 1 Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH Reactome DB_ID: 9962232 1 RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] RNA Polymerase II holoenzyme complex (hyperphosphorylated) Reactome DB_ID: 9956745 1 UniProt:A0A5F4D7H3 POLR2D UniProt A0A5F4D7H3 1 EQUAL 142 EQUAL Reactome DB_ID: 9956761 1 UniProt:A0A5F4CA55 UniProt A0A5F4CA55 1 EQUAL 58 EQUAL Reactome DB_ID: 9956741 1 UniProt: E2RNN5 POLR2B UniProt E2RNN5 1 EQUAL 1174 EQUAL Reactome DB_ID: 9956753 1 UniProt: E2RQ42 POLR2C UniProt E2RQ42 2 EQUAL 275 EQUAL Reactome DB_ID: 9956757 1 UniProt:A0A5F4CEJ9 POLR2H UniProt A0A5F4CEJ9 2 EQUAL 150 EQUAL Reactome DB_ID: 9956771 1 Ghost homologue of POLR2L [nucleoplasm] Ghost homologue of POLR2L Reactome DB_ID: 9956737 1 UniProt: E2QYJ4 POLR2I UniProt E2QYJ4 1 EQUAL 125 EQUAL Reactome DB_ID: 9962230 1 UniProt:J9NW09 POLR2A UniProt J9NW09 O-phospho-L-serine at 5 (in Homo sapiens) 5 EQUAL O-phospho-L-serine [MOD:00046] O-phospho-L-serine at 2 (in Homo sapiens) 2 EQUAL 1 EQUAL 1970 EQUAL Reactome DB_ID: 9956733 1 UniProt: E2RD80 POLR2J UniProt E2RD80 1 EQUAL 117 EQUAL Reactome DB_ID: 9956769 1 UniProt:A0A5F4CKL9 POLR2F UniProt A0A5F4CKL9 2 EQUAL 127 EQUAL Reactome DB_ID: 9956765 1 UniProt:F6X571 POLR2E UniProt F6X571 1 EQUAL 210 EQUAL Reactome DB_ID: 9956749 1 UniProt:F1PT38 POLR2G UniProt F1PT38 1 EQUAL 172 EQUAL Reactome Database ID Release 77 9962232 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9962232 Reactome R-CFA-109909 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-109909.1 Reactome DB_ID: 9958810 1 TFIIH [nucleoplasm] TFIIH Reactome DB_ID: 9958792 1 UniProt:A0A5F4DHJ6 GTF2H3 UniProt A0A5F4DHJ6 1 EQUAL 308 EQUAL Reactome DB_ID: 9958804 1 UniProt: E2RCX0 GTF2H1 UniProt E2RCX0 1 EQUAL 548 EQUAL Reactome DB_ID: 9958800 1 UniProt:F1PGI3 GTF2H4 UniProt F1PGI3 1 EQUAL 462 EQUAL Reactome DB_ID: 9958788 1 UniProt: E2RN68 ERCC3 UniProt E2RN68 1 EQUAL 782 EQUAL Reactome DB_ID: 9958796 1 UniProt:F6XXE1 GTF2H2 UniProt F6XXE1 1 EQUAL 395 EQUAL Reactome DB_ID: 9958808 1 UniProt: E2RRJ1 GTF2H5 UniProt E2RRJ1 1 EQUAL 71 EQUAL Reactome DB_ID: 9958780 1 CAK [nucleoplasm] CAK Reactome DB_ID: 9958774 1 UniProt: E2R5P2 CCNH UniProt E2R5P2 1 EQUAL 323 EQUAL Reactome DB_ID: 9958770 1 UniProt: E2R8R3 CDK7 UniProt E2R8R3 1 EQUAL 346 EQUAL Reactome DB_ID: 9958778 1 UniProt:A0A5F4CWN6 MNAT1 UniProt A0A5F4CWN6 1 EQUAL 309 EQUAL Reactome Database ID Release 77 9958780 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9958780 Reactome R-CFA-69221 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-69221.1 Reactome DB_ID: 9958784 1 UniProt:A0A5F4D6E4 ERCC2 UniProt A0A5F4D6E4 1 EQUAL 760 EQUAL Reactome Database ID Release 77 9958810 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=9958810 Reactome R-CFA-109634 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-109634.1 Reactome DB_ID: 110291 1 damaged DNA substrate:nascent mRNA hybrid [nucleoplasm] damaged DNA substrate:nascent mRNA hybrid Reactome Database ID Release 77 10022840 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022840 Reactome R-CFA-6781822 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781822.1 Reactome Database ID Release 77 10022845 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022845 Reactome R-CFA-6781837 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781837.1 Reactome DB_ID: 10021011 1 Reactome DB_ID: 10022855 1 Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 Reactome DB_ID: 10022851 1 Reactome DB_ID: 10022845 1 Reactome Database ID Release 77 10022855 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022855 Reactome R-CFA-6781839 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781839.1 Reactome Database ID Release 77 10022857 数据库标识符。使用这个URL连接到the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser?DB=gk_current&ID=10022857 Reactome R-CFA-6781833 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: //www.joaskin.com/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-6781833.1 Cockayne syndrome protein A (ERCC8, also known as CSA) is recruited to a stalled RNA polymerase II complex (RNA Pol II) at a site of DNA damage in an ERCC6 (CSB) dependent manner (Fousteri et al. 2006). ERCC8 is part of an ubiquitin ligase complex that, in addition to ERCC8, also contains DDB1, CUL4 (CUL4A or CUL4B) and RBX1 (Groisman et al. 2003). The COP9 signalosome complex prevents the ubiquitin ligase activity of the ERCC8:DDB1:CUL4:RBX1 at the early steps after DNA damage induction (Groisman et al. 2003, Fischer et al. 2011). 16916636 Pubmed 2006 Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo Fousteri, Maria Vermeulen, Wim van Zeeland, Albert A Mullenders,莱昂H F Mol. Cell 23:471-82 12732143 Pubmed 2003 The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage Groisman, Regina Polanowska, Jolanta Kuraoka, Isao Sawada, Jun-ichi Saijo, Masafumi Drapkin, Ronny Kisselev, Alexei F Tanaka, Kiyoji Nakatani, Yoshihiro Cell 113:357-67 22118460 Pubmed 2011 The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation Fischer, Eric S Scrima, Andrea Böhm, Kerstin Matsumoto, Syota Lingaraju, Gondichatnahalli M Faty, Mahamadou Yasuda, Takeshi Cavadini, Simone Wakasugi, Mitsuo Hanaoka, Fumio Iwai, Shigenori Gut, Heinz Sugasawa, Kaoru Thomä, Nicolas H Cell 147:1024-39 inferred by electronic annotation IEA GO IEA