SBML generated from Reactome version 77 on 8/19/21 1:47 PM using JSBML version 1.5.
Derived from a Reactome Complex. Here is Reactomes nested structure for this complex: (17189, Q8WUG5, P80188). Reactome uses a nested structure for complexes, which cannot be fully represented in SBML Level 3 Version 1 core
来自Reactome SimpleEntity。这是一个small compound
Derived from a Reactome EntityWithAccessionedSequence. This is a protein
Derived from a Reactome Complex. Here is Reactomes nested structure for this complex: (29034, 17189, Q8WUG5, P80188). Reactome uses a nested structure for complexes, which cannot be fully represented in SBML Level 3 Version 1 core
Neutrophil gelatinase-associated lipocalin (LCN2, NGAL) is a member of the lipocalin superfamily that is involved in iron trafficking both in and out of cells (Goetz et al. 2002). LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. The iron-bound form of LCN2 (holo-LCN2) is internalised following binding to the solute carrier family 22 member 17 (SLC22A17) receptor, leading to release of iron which increases intracellular iron concentration and subsequent inhibition of apoptosis. This step is inferred from experiments using the highly homologous 24p3 mouse lipocalin and 24p3R mouse cell surface receptor (Devireddy et al. 2005).